Article
Public, Environmental & Occupational Health
Qi Pan, Sijia Fei, Lina Zhang, Huan Chen, Jingyi Luo, Weihao Wang, Fei Xiao, Lixin Guo
Summary: This study aims to evaluate the cost and quantity of anti-diabetic drugs needed by patients with or without diabetic peripheral neuropathy (DPN) in Beijing between 2016 and 2018. The study found that DPN patients used more medications to treat complications and comorbidities compared to non-DPN patients, and the annual drug treatment costs were higher in DPN patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Jia-Lin Yuan, Le Sun, Bao-Lin Su, Chuang-Xiong Hong
Summary: This case presents a specific adverse drug reaction of corticosteroids that causes diabetes mellitus and subsequently leads to peripheral neuropathy in an acute onset. Mecobalamin and Acupuncture were employed and steroids were discontinued, 8 months later he recovered part of his strength and sensation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Petra Baum, Klaus V. Toyka, Matthias Blueher, Joanna Kosacka, Marcin Nowicki
Summary: The pathogenesis of diabetic neuropathy is complex, with low-grade intraneural inflammation being a common feature. In addition to iron deficiency, obesity and dyslipidemia may also contribute to neuropathy. Anti-inflammatory compounds with different modes of action could potentially be used for treatment or prevention of diabetic neuropathy if further substantiated by human tissue data and intervention studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Zhanyi Li, Wen Wang, Fengping Meng, Zhuqing Zhou, Zhongqiu Zhao, Zhinan Mei
Summary: This study aimed to investigate the therapeutic effects of Baimai (BM) ointment on diabetes peripheral neuropathy (DPN) and explore its underlying mechanisms. The results showed that BM ointment can relieve pain hypersensitivity and protect against peripheral nerve damage caused by DPN, possibly through the inhibition of neuropeptide and chemokine expression and the regulation of PI3K/AKT and MAPKs signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jonathan Enders, Daniel Elliott, Douglas E. Wright
Summary: Diabetic peripheral neuropathy (DPN) is a complication of metabolic syndrome and diabetes, causing sensory changes such as slow nerve conduction, nerve degeneration, loss of sensation, pain, and gait abnormalities. Nonpharmacologic approaches, including dietary interventions and exercise, show promise in treating DPN. These lifestyle interventions have the potential to provide meaningful relief for patients and identify new therapeutic targets.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Pharmacology & Pharmacy
Tianyu Xue, Xin Zhang, Yiwen Xing, Shuhan Liu, Lijun Zhang, Xun Wang, Min Yu
Summary: Diabetic peripheral neuropathy is closely related to immune-inflammatory mechanisms, and treatment options are diverse, including both drug and non-drug therapies. The future direction of development lies in exploring more effective treatment strategies and identifying new therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Jamie Burgess, Bernhard Frank, Andrew Marshall, Rashaad S. Khalil, Georgios Ponirakis, Ioannis N. Petropoulos, Daniel J. Cuthbertson, Rayaz A. Malik, Uazman Alam
Summary: Diabetic peripheral neuropathy is a common complication of diabetes that significantly impacts quality of life and healthcare burden. Current screening methods for early detection of DPN have limitations, highlighting the need for further research and clinical practices to improve accuracy and early detection.
Review
Neurosciences
Yifan Cheng, Yinuo Chen, Kezheng Li, Shuwei Liu, Chunyang Pang, Lingfei Gao, Jiali Xie, L. V. Wenjing, Huan Yu, Binbin Deng
Summary: This review aims to summarize the current knowledge on the pathogenesis of DPN, with a focus on the mechanism and application of inflammatory response.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Endocrinology & Metabolism
Cunqing Yang, Xuefei Zhao, Xuedong An, Yuehong Zhang, Wenjie Sun, Yuqing Zhang, Yingying Duan, Xiaomin Kang, Yuting Sun, Linlin Jiang, Fengmei Lian
Summary: Diabetic peripheral neuropathy is a chronic metabolic disease that seriously affects patients' quality of life and can lead to amputation and neuropathic pain. Current treatment options only address symptoms and do not reverse nerve damage. Understanding the underlying mechanisms is crucial for prevention and the development of new therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Vered H. Eisenberg, Dean H. Decter, Gabriel Chodick, Varda Shalev, Clara Weil
Summary: The goal of this study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. The study found that endometriosis was significantly associated with infertility, comorbidities, higher utilization of healthcare services, pain medications, and antidepressants, as well as higher direct medical costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Erika Salvi, Gidon J. Boenhof, Dan Ziegler, Rayaz A. Malik, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: Neuropathic pain is common in diabetic peripheral neuropathy (DN), and it may be caused by pathogenic ion channel gene variants. Variants in ion channel genes were found in DN patients with and without pain, suggesting their role in pain generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen
Summary: The study found that magnolol (MG) can improve neurological dysfunctions in diabetic peripheral neuropathy (DPN) mice, promote neurite outgrowth, protect nerve structure, and regulate inflammation and apoptosis processes through multiple pathways. These results reveal the potential of MG as a treatment for DPN and provide further understanding of its mechanism of action.
Review
Cell Biology
Wei Zheng So, Natalie Shi Qi Wong, Hong Chang Tan, Molly Tzu Yu Lin, Isabelle Xin Yu Lee, Jodhbir S. Mehta, Yu-Chi Liu
Summary: This article reviews the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy, including their pathogenesis, clinical presentation, evaluation, and management. It emphasizes the importance of diabetic corneal neuropathy as a surrogate marker for detecting diabetic peripheral neuropathy.
NEURAL REGENERATION RESEARCH
(2022)
Review
Medicine, General & Internal
Jingjing Li, Ruiqian Guan, Limin Pan
Summary: This article reviews the mechanism of Schwann cells (SCs) in diabetic peripheral neuropathy (DPN), and finds that SCs are closely related to pathogenic processes such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support, and dyslipidemia in DPN.
Review
Endocrinology & Metabolism
Hideji Yako, Naoko Niimi, Shizuka Takaku, Kazunori Sango
Summary: Studies have shown that lipid metabolism and inflammation pathways associated with DPN are regulated at the gene expression level in diabetes animal models. These pathways are also conserved in human DPN, revealing the important pathogenesis of DPN. Omics approaches can help us better understand the association between metabolic changes and morphological and functional abnormalities in DPN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
