Article
Reproductive Biology
Ryan M. Brown, Linda Wang, Anqi Fu, Athilakshmi Kannan, Michael Mussar, Indrani C. Bagchi, Joan S. Jorgensen
Summary: Irx3 promotes successful embryo-uterine interactions in mice.
BIOLOGY OF REPRODUCTION
(2022)
Article
Immunology
Yue Li, Si-Ting Chen, Yu-Ying He, Bo Li, Chen Yang, Zhen-Shan Yang, Zeng-Ming Yang
Summary: In this study, the involvement of secreted HMGB1 in early mouse pregnancy was investigated. It was found that HMGB1 can be detected in the uterine lumen fluid and its secretion is influenced by the presence of blastocysts. The presence of trypsin in blastocysts and its ability to stimulate HB-EGF production was also demonstrated. Furthermore, the role of PAR2-HMGB1-ADAM17-HB-EGF signaling pathway in decidualization was identified.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yi Yang, Qiu-Yang Zhu, Ji-Long Liu
Summary: This study utilized single-cell RNA sequencing to investigate uterine receptivity in mice, revealing 19 distinct cell clusters and identifying global gene expression changes associated with uterine receptivity in each cell type. The data provide a valuable resource for understanding the molecular mechanisms underlying uterine receptivity.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Ewa Monika Drzewiecka, Wiktoria Kozlowska, Agata Zmijewska, Pawel Jozef Wydorski, Anita Franczak
Summary: Electromagnetic fields can alter the expression levels of CYP19A3 and HSD17B4 in pig myometrium during the peri-implantation period, while progesterone may mitigate the effects of EMF, regulating the expression levels of aromatase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Kailiang Li, Quanxi Li, Shah Tauseef Bashir, Brent M. Bany, Romana A. Nowak
Summary: Conditional knockout of Basigin results in decreased fertility in mice, with abnormalities in implantation, decidualization, placentation, and parturition in the uteri of knockout mice. This suggests that Basigin plays a critical role in successful pregnancy through its functions in implantation and decidualization.
BIOLOGY OF REPRODUCTION
(2021)
Review
Physiology
Manasi Malik, Michelle Roh, Sarah K. England
Summary: The review provides a summary of studies on uterine excitation and contractions in mice, rats, guinea pigs, and humans, aiming to help new researchers understand the field and provide assistance in experimental design and result interpretation in rodent models.
Article
Biology
Mitsunori Matsuo, Jia Yuan, Yeon Sun Kim, Amanda Dewar, Hidetoshi Fujita, Sudhansu K. Dey, Xiaofei Sun
Summary: This study reveals that mice with uterine depletion of Foxa2 may enter embryonic diapause, with Msx1 and LIF potentially playing a role in resuming pregnancy.
Article
Biochemistry & Molecular Biology
Zhen-Shan Yang, Hai-Yang Pan, Wen-Wen Shi, Si-Ting Chen, Ying Wang, Meng-Yuan Li, Hai-Yi Zhang, Chen Yang, Ai-Xia Liu, Zeng-Ming Yang
Summary: The study reveals that Laminin A5 may play a crucial role during decidualization in mice and humans, especially through the PKA-CREB-C/EBP beta pathway. Additionally, knockdown of Laminin A5 inhibits the process of decidualization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Marta Rybska, Magdalena Wozna-Wysocka, Barbara Wasowska, Marek Skrzypski, Magdalena Kubiak, Beata Blaszak, Anna Lukomska, Tomasz Nowak, Jedrzej M. Jaskowski
Summary: Pathomorphological changes and functional disorders of the uterus have long been a significant problem in dog reproduction, with cystic endometrial hyperplasia (CEH) and pyometra as common uterine diseases. TGF-beta 1 expression was significantly increased in endometrial tissues affected by CEH-pyometra in bitches, suggesting its potential role as a key factor in regulating the endometrium.
Article
Microbiology
Li Wang, Junyu Chen, Lin He, Hanbo Liu, Yan Liu, Zonghui Luan, Hong Li, Weixin Liu, Mengjun Luo
Summary: The aim of this study was to investigate the distribution and differences in the uterus and vaginal microbiome between women with early embryonic arrest and those with normal pregnancy using high-throughput sequencing. The results showed significant differences in Lactobacillus, Bacteroidetes, and Helicobacter in the vagina between the two groups. The study also identified specific dominant bacterial species and genera in both the vagina and uterus.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Youki Takezawa, Maki Iwai, Yukiko Fujiki, Ryo Yokomizo, Harue Kishigami, Mami Miyado, Natsuko Kawano, Mitsutoshi Yamada, Miyuki Shindo, Miki Suzuki, Ban Sato, Daiki Katano, Shintaro Kamijo, Toshio Hamatani, Mamoru Tanaka, Akihiro Umezawa, Woojin Kang, Kenji Miyado
Summary: Repeated implantation failure is a common cause of infertility in healthy women. The role of embryonic CTNNB1 in implantation is not well understood. Using mouse models, researchers found that Ctnnb1(Delta/Delta) embryos developed to the blastocyst stage but were subsequently resorbed, leaving empty decidual capsules. The absence of leukemia inhibitory factor and CDX2 in Ctnnb1(Delta/Delta) blastocysts indicates the importance of embryonic CTNNB1 in the secretion of blastocyst-derived factors and the proper development of trophectoderm cells. Intrauterine injection of uterine fluids and leukemia inhibitory factor proteins rescued the uterine response to Ctnnb1(Delta/Delta) blastocysts, suggesting a potential therapeutic approach for improving implantation. These findings contribute to a better understanding of the pathogenesis of repeated implantation failure.
LABORATORY INVESTIGATION
(2023)
Article
Cell Biology
Qinsheng Lu, Dingqian Sun, Sourima Biswas Shivhare, Huomei Hou, Judith N. Bulmer, Barbara A. Innes, Dharani K. Hapangama, Gendie E. Lash
Summary: Appropriate growth and development of the endometrium is crucial for a woman's quality of life and reproductive health, while conditions like heavy menstrual bleeding and recurrent pregnancy loss significantly impact women's quality of life and healthcare systems. TGF beta 1 plays a key role in regulating endometrial vascular maturation and could be a potential therapeutic target for women with HMB and/or RPL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Kacie A. Norton, Farshad Niri, Chelsey B. Weatherill, Christine E. Williams, Kevin Duong, Heather E. McDermid
Summary: Despite seemingly normal oogenesis, female mice with mutations in the chromatin remodeling gene Cecr2 are subfertile, with a reduced litter size due to embryo loss occurring either before E5.5 or at approximately E10 depending on the mutant allele.
BIOLOGY OF REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward, Joel S. Caton, Marta Czernik, Luca Palazzese, Pasqualino Loi, Lawrence P. Reynolds
Summary: Assisted reproductive techniques (ART) and parental nutritional status have significant impacts on embryonic and fetal development, potentially mediated through programming of gene expression. Epigenetic changes may lead to long-term alterations in organ structure and function in offspring after birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Kiyoshi Terawaki, Yayoi Saegusa, Kyoji Sekiguchi, Tomofumi Shimizu, Mikina Takiyama, Takashi Matsumoto, Seiichi Iizuka, Chinami Matsumoto, Fukuhito Motoyama
Summary: The study demonstrates that TSS can ameliorate implantation failure in rats induced by a progesterone antagonist, potentially through alleviating decreased LIF production and dysfunction of decidualization, including lower progesterone responsiveness.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
