The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2–STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells

Basic Transcription Factor 3 Is Required for Proliferation and Epithelial‐Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer

(2017) De-Zhong Zhang et al.   ONCOLOGY RESEARCH

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

(2017) Jennifer Huynh et al.   SEMINARS IN CANCER BIOLOGY

3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells

(2016) Kecheng Lei et al.   BIOMEDICINE & PHARMACOTHERAPY

Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis

(2016) Yuting Cui et al.   FOOD AND CHEMICAL TOXICOLOGY

CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence

(2016) N Garg et al.   ONCOGENE

Molecular targets of curcumin for cancer therapy: an updated review

(2016) Pandima Devi Kasi et al.   TUMOR BIOLOGY

Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent

(2016) Daniel P. Ball et al.   Oncotarget

World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015

(2016) Shelley McGuire   Advances in Nutrition

miR-150 Suppresses the Proliferation and Tumorigenicity of Leukemia Stem Cells by Targeting the Nanog Signaling Pathway

(2016) Dan-dan Xu et al.   Frontiers in Pharmacology

Global patterns of cardia and non-cardia gastric cancer incidence in 2012

(2015) A Colquhoun et al.   GUT

Curcumin inhibits Ec109 cell growth via an AMPK-mediated metabolic switch

(2015) Feng-Juan Zhang et al.   LIFE SCIENCES

Involvement of ROS-p38-H2AX axis in novel curcumin analogues-induced apoptosis in breast cancer cells

(2015) Yinhui Dong et al.   MOLECULAR CARCINOGENESIS

Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway

(2015) Jun-Ru Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Effects of Curcumin Analogues for Inhibiting Human Prostate Cancer Cells and the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice

(2014) Dai-Ying Zhou et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation

(2014) DAI-YING ZHOU et al.   Molecular Medicine Reports

Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability

(2014) Bo Ram Seo et al.   PLoS One

Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma

(2014) Georgina V. Long et al.   Nature Communications

Sorcin silencing inhibits epithelial-to-mesenchymal transition and suppresses breast cancer metastasis in vivo

(2013) Yunhui Hu et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line

(2013) Miao Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transcription factor AP-2α regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression

(2013) Xiaofeng Ding et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oesophageal carcinoma

(2013) Arjun Pennathur et al.   LANCET

Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma

(2012) Makoto Adachi et al.   ORAL ONCOLOGY

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma

(2012) Brendan D. Looyenga et al.   PLoS One

Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling

(2012) Dharmalingam Subramaniam et al.   PLoS One

Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030

(2011) L Lin et al.   BRITISH JOURNAL OF CANCER

Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways

(2011) Shengkai Liao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dedicated to evidence-based medicine and the evaluation of new therapeutic approaches in the field

(2011) Christoph Schindler   Therapeutic Advances in Endocrinology and Metabolism

Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma

(2010) Yu-Cai Wang et al.   ACTA HISTOCHEMICA

Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro

(2010) Jayaraj Ravindran et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

(2010) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Curcumin Inhibits Constitutive STAT3 Phosphorylation in Human Pancreatic Cancer Cell lines and Downregulation of Survivin/BIRC5 Gene Expression

(2010) W. Glienke et al.   CANCER INVESTIGATION

Differential Inhibition of Protein Translation Machinery by Curcumin in Normal, Immortalized, and Malignant Oral Epithelial Cells

(2010) N. Chakravarti et al.   Cancer Prevention Research

Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

(2010) L. Lin et al.   CANCER RESEARCH

Is Stat3 and/or p53 mRNA expression a prognostic marker for renal cell carcinoma?

(2009) Akinori Masuda et al.   BIOMEDICAL RESEARCH-TOKYO

Structure–activity relationship studies of curcumin analogues

(2009) James R. Fuchs et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: Their inhibition by curcumin

(2009) Ji Hye Seo et al.   CANCER LETTERS

Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells

(2009) R. Behera et al.   CARCINOGENESIS

Heredity, diet and lifestyle as determining risk factors for the esophageal cancer on Nanao Island in Southern China

(2009) Min Liu et al.   Familial Cancer

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

(2009) Pay-Chin Leow et al.   INVESTIGATIONAL NEW DRUGS

Synergistic Role of Curcumin With Current Therapeutics in Colorectal Cancer: Minireview

(2009) Bhaumik B. Patel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Editorial [ Apoptosis, Necrosis and Autophagy: From Mechanisms to Biomedical Applications (Part-I) Guest Editor: Claudio Hetz ]

(2008) Claudio Hetz   CURRENT MOLECULAR MEDICINE

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New mechanisms and therapeutic potential of curcumin for colorectal cancer

(2008) Isabel Villegas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE