Review
Cell Biology
Weida Ren, Wanyu Zhao, Lingbo Cao, Junqi Huang
Summary: Research on programmed cell death (PCD) reveals that cells undergo orderly cell death through evolutionary regulatory mechanisms, with actin playing a crucial role in cellular processes. Scientists aim to further understand the intricate relationship between PCD and the actin cytoskeleton.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qingchun Lu, Po-Shun Wang, Ling Yang
Summary: This review focuses on highlighting Golgi-associated Rab GTPases as master regulators of autophagic flux, discussing the future research prospects in elucidating their role and mechanism in autophagy and autophagy-related diseases.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Jialing Wang, Xiaodan Liu, Haixia Wang, Lili Qin, Anhua Feng, Daoxin Qi, Haihua Wang, Yao Zhao, Lihua Kong, Haiying Wang, Lin Wang, Zhenbo Hu, Xin Xu
Summary: The histone demethylase JMJD1C is associated with human platelet counts and plays a role in megakaryopoiesis. The study used various models and samples to investigate the expression and function of JMJD1C. The results suggest that JMJD1C may regulate megakaryopoiesis by influencing the actin network.
Article
Biochemistry & Molecular Biology
Aaron M. N. Joiner, Ben P. Phillips, Kumar Yugandhar, Ethan J. Sanford, Marcus B. Smolka, Haiyuan Yu, Elizabeth A. Miller, J. Christopher Fromme
Summary: The study revealed the regulation of Rab1 activation by the TRAPPIII complex, with the Trs85 subunit serving as a membrane anchor for the entire complex via its amphipathic helix. These findings provide a structural understanding of Rab activation on organelle and vesicle membranes.
Article
Cell Biology
Willow Hight-Warburton, Robert Felix, Andrew Burton, Hannah Maple, Magda S. Chegkazi, Roberto A. Steiner, John A. McGrath, Maddy Parsons
Summary: The adhesion of basal keratinocytes to the ECM through integrin receptors is crucial for skin homeostasis and response to injury. Alpha 4 beta 1 and alpha 9 beta 1 integrins play roles in regulating migration by suppressing ERK1/2 activity and controlling downstream kinases like MSK1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Feifei Xu, Zining Wang, Hongxia Zhang, Jiemin Chen, Xiaojuan Wang, Lei Cui, Chunyuan Xie, Mengyun Li, Fang Wang, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaodong Xia, Xiaojun Xia
Summary: This study demonstrates that inhibition of the MVA metabolic pathway in tumor cells promotes antitumor immunity through a cDC1 response mediated by CLEC9A recognition of tumor cell cytoskeleton, providing insight into a new immune surveillance mechanism and the potential for targeting this axis in cancer immunotherapy.
Article
Cell Biology
Dilip Menon, Apoorva Bhapkar, Bhoomika Manchandia, Gitanjali Charak, Surabhi Rathore, Rakesh Mohan Jha, Arpita Nahak, Moumita Mondal, Mohyeddine Omrane, Akash Kumar Bhaskar, Lipi Thukral, Abdou Rachid Thiam, Sheetal Gandotra
Summary: Lipid droplets are important organelles that maintain cellular lipid balance by storing and delivering lipids. The small GTPase ARL8B has been found to mediate lipid droplet turnover in lysosomes, facilitating efficient lipid transfer between these organelles and potentially offering insights into inflammatory disorders.
Article
Multidisciplinary Sciences
Timothy J. Hawkins, Michaela Kopischke, Patrick J. Duckney, Katarzyna Rybak, David A. Mentlak, Johan T. M. Kroon, Mai Thu Bui, A. Christine Richardson, Mary Casey, Agnieszka Alexander, Geert De Jaeger, Monika Kalde, Ian Moore, Yasin Dagdas, Patrick J. Hussey, Silke Robatzek
Summary: This study reveals that NET4A and NET4B members of the NET family play an essential role in the reorganization of guard cell actin during stomatal closure, mediating the molecular link between actin filaments and the tonoplast through interaction with RABG3b.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Jiayi Liu, Xuanjun Zheng, Xiaoqian Wu
Summary: This review summarizes the importance of Rab GTPase in cardiovascular diseases and suggests its potential as a therapeutic target.
Article
Oncology
Yuan Dong, Qiu Jin, Minghao Sun, Da Qi, Huinan Qu, Xinqi Wang, Chengshi Quan
Summary: CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton assembly and activation of autophagy. This finding contributes to the understanding of breast cancer and provides a potential biomarker for diagnosis and therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Fabian R. Villagomez, Juan D. Diaz-Valencia, Erasmo Ovalle-Garcia, Armando Antillon, Ivan Ortega-Blake, Hector Romero-Ramirez, Jorge F. Cerna-Cortes, Roberto Rosales-Reyes, Leopoldo Santos-Argumedo, Genaro Patino-Lopez
Summary: Cell spreading and phagocytosis are regulated by small GTPases and GAP proteins, with TBC1D10C identified as a dual inhibitory protein with GAP activity. TBC1D10C modulates lymphocyte activation in immune cells, and our study reveals its involvement in reorganizing the cytoskeleton and plasma membrane of macrophages, impacting cell spreading and phagocytic activity.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jonathan E. Tullis, Ulrich Bayer
Summary: The death-associated protein kinase 1 (DAPK1) regulates the synaptic movement of the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) by binding to the NMDA-receptor subunit GluN2B. The localization of DAPK1 at synapses requires F-actin as well as an additional binding mode, likely to GluN2B, during long-term depression (LTD). Both modes of synaptic DAPK1 localization work together to regulate synaptic CaMKII localization and therefore synaptic plasticity.
Article
Multidisciplinary Sciences
Ka Man Carmen Chan, Ashley L. Arthur, Johannes Morstein, Meiyan Jin, Abrar Bhat, Dorte Schlesinger, Sungmin Son, Donte A. Stevens, David G. Drubin, Daniel A. Fletcher
Summary: Fusion-associated small transmembrane (FAST) proteins are a diverse family of nonstructural viral proteins that drive cell-cell fusion, increasing viral spread and pathogenicity. Unlike viral fusogens with tall ectodomains, FAST proteins have short fusogenic ectodomains that cannot bridge the intermembrane gap between neighboring cells. This work suggests that localized mechanical pressure on the plasma membrane coupled to a membrane-disruptive ectodomain is sufficient to drive cell-cell fusion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Philip M. Graybill, Aniket Jana, Rakesh K. Kapania, Amrinder S. Nain, Rafael Davalos
Summary: Post-electroporation cell force undergoes three distinct stages: initial rounding and loss of contractility, followed by a biphasic stage characterized by increased contractility and subsequent force relaxation, and finally cell elongation and recovery of contractility. Increasing voltages applied perpendicular to cell orientation lead to a significant drop in cell viability, indicating that contractile force is a more sensitive metric than cell shape to electroporation.
Review
Biochemistry & Molecular Biology
Eleonora Sarantelli, Apostolis Mourkakis, Lefteris C. Zacharia, Andreas Stylianou, Vasiliki Gkretsi
Summary: As metastasis is a major cause of cancer-related deaths, understanding the cellular and molecular events involved in cancer cell migration and invasion is crucial for developing novel anti-metastatic therapies. Fascin-1, an actin-bundling protein, plays a fundamental role in cell migration processes. It is significantly elevated in most cancers and its high expression is associated with aggressive disease and poor prognosis. Recent studies show that Fascin-1 is critically involved in metastasis and suggest it as a promising target for anti-metastatic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)