Review
Nutrition & Dietetics
Piotr Kulig, Karolina Luczkowska, Anna Bielikowicz, Debora Zdrojewska, Bartlomiej Baumert, Boguslaw Machalinski
Summary: This literature review summarizes the research conducted on vitamin D and multiple myeloma (MM), focusing on its effects on immune system modulation, induction of malignant MM cell differentiation, synergistic activity with anti-MM drugs, and MM-associated peripheral neuropathy.
Review
Nutrition & Dietetics
Alberto Caballero-Garcia, Alfredo Cordova-Martinez, Nestor Vicente-Salar, Enrique Roche, Daniel Perez-Valdecantos
Summary: Vitamin D plays a crucial role in immune modulation, enhancing macrophage functions and modulating muscle inflammatory response and protein synthesis. It is particularly important in cases of deficiency or high muscular demand.
Editorial Material
Biotechnology & Applied Microbiology
Manish Dhawan, Priyanka, Om Prakash Choudhary
Summary: Vitamin D deficiency is associated with an increased risk of hospitalization for COVID-19 patients. Vitamin D plays a role in regulating the renin-angiotensin system and the immune system, reducing inflammation and promoting Th2 immune response and activation of defensive cells. However, current research has not reached a consensus on the direct impact of vitamin D on COVID-19 prognosis.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Fabienne Jaun, Maria Boesing, Giorgia Luethi-Corridori, Kristin Abig, Nando Bloch, Stephanie Giezendanner, Victoria Grillmayr, Philippe Haas, Anne B. Leuppi-Taegtmeyer, Juergen Muser, Andrea Raess, Philipp Schuetz, Michael Brandle, Joerg D. Leuppi
Summary: The role of vitamin D in the COVID-19 pandemic has been controversial, and the effectiveness of vitamin D-3 supplementation in COVID-19 patients remains inconclusive. This study conducted a randomized, placebo-controlled double-blind trial on hospitalized COVID-19 patients to compare the effect of high-dose vitamin D-3 supplementation on length of hospital stay. The results showed that vitamin D-3 supplementation did not significantly shorten the hospital stay.
Review
Public, Environmental & Occupational Health
Daniela Briceno Noriega, Huub F. J. Savelkoul
Summary: Vitamin D deficiency is associated with various diseases and may play a role in the prevention and mitigation of COVID-19, particularly in high-risk populations and hospitalized patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Infectious Diseases
Giulia Patti, Carmen Pellegrino, Aurelia Ricciardi, Roberta Novara, Sergio Cotugno, Roberta Papagni, Giacomo Guido, Valentina Totaro, Giuseppina De Iaco, Federica Romanelli, Stefania Stolfa, Maria Letizia Minardi, Luigi Ronga, Ilenia Fato, Rossana Lattanzio, Davide Fiore Bavaro, Gina Gualano, Loredana Sarmati, Annalisa Saracino, Fabrizio Palmieri, Francesco Di Gennaro
Summary: Supplementation with multiple micronutrients, including zinc, may be more beneficial in TB compared to vitamin A alone. Vitamin C at high concentrations sterilizes drug-resistant TB cultures and prevents the emergence of drug persisters; Vitamin D suppresses mycobacterium replication in vitro, while VE shows a promising role in TB management due to its connection with oxidative balance.
Article
Biochemistry & Molecular Biology
Geysson Javier Fernandez, Julieta M. Ramirez-Mejia, Silvio Urcuqui-Inchima
Summary: Vitamin D enhances immune response by regulating the expression of microRNAs and mRNAs in macrophage differentiation. Differentially expressed genes are associated with pathophysiological processes such as inflammatory responses and cellular stress. MiRNAs, including miR-1972, miR-1273h-5p, and miR-665, regulate genes related to the inflammatory response.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Danilo Tarsio Mota Brito, Luiza Helena Coutinho Ribeiro, Carla Hilario da Cunha Daltro, Roberto de Barros Silva
Summary: Research has shown that vitamin D may have benefits in COVID-19, with low serum levels of vitamin D being associated with disease severity and potentially serving as a possible prophylactic and treatment for infection.
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Davaasambuu Ganmaa, Tserendorj Chinbayar, Polyna Khudaykov, Erdenebileg Nasantogtoh, Sukhbaatar Ariunbuyan, Tserenkhuu Enkhtsetseg, Ganbold Sarangua, Andrew Chan, Dalkh Tserendagva
Summary: In Mongolian inpatients with COVID-19, active TB infection, older age, male gender, and COPD were associated with greater disease severity, while a history of COVID-19 vaccination and the presence of a BCG vaccination scar were protective.
Article
Endocrinology & Metabolism
Nitin Kapoor, Sanjay Kalra
Summary: Vitamin D deficiency is common and has been associated with metabolic bone disease. Recently, its role in immune modulation and its impact on COVID-19 infection, severity, and prognosis have gained importance.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Alice Albergamo, Giulia Apprato, Francesca Silvagno
Summary: The genomic activity of vitamin D has significant effects on metabolism and physiological functions, particularly in relation to viral infections such as COVID-19. This review examines the correlation between vitamin D deficiency and increased risks of severe COVID-19 and respiratory distress syndrome. Clinical trials have tested vitamin D supplementation with promising results. Additionally, a biochemical analysis explores the antioxidant and anti-inflammatory functions of vitamin D and its influence on different biochemical pathways in the body's defense against viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Cristiano Pagnini, Andrea Picchianti-Diamanti, Vincenzo Bruzzese, Roberto Lorenzetti, Michele Maria Luchetti, Louis Severino Martin Martin, Roberta Pica, Palma Scolieri, Maria Lia Scribano, Costantino Zampaletta, Maria Sole Chimenti, Bruno Lagana
Summary: This article examines the complex interconnections between vitamin D signaling, gut barrier integrity, microbiota composition, and the immune system, and presents the potential clinical applications of utilizing the vitamin D pathway in the context of inflammatory bowel disease and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Lisa Stockdale, Basil Sambou, Muhamed Sissoko, Uzochukwu Egere, Abdou K. Sillah, Beate Kampmann, Robin Basu Roy
Summary: This study found that children with equal exposure to a TB case had higher levels of vitamin D if they were not infected, despite there being no significant difference in vitamin D levels between infected and uninfected children. The relationship between vitamin D levels and TB infection risk requires further investigation in larger studies to fully understand the implications and significance.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Ester Lilian Acen, Irene Andia Biraro, Mudarshiru Bbuye, David Patrick Kateete, Moses L. Joloba, William Worodria
Summary: The aim of this study was to determine the association between vitamin D deficiency and TB status among patients with active TB, latent TB infection (LTBI) and those without TB infection. The study found that the vitamin D levels of active TB patients were significantly lower compared to individuals with LTBI and those without TB infection.
SCIENTIFIC REPORTS
(2022)