Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets

PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy

(2018) Kenneth K.W. To et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of microsomal epoxide hydrolase, Na+ -taurocholate cotransporting polypeptide, and organic anion transporting polypeptide in hepatic sodium-dependent bile acid transport

(2018) Daniel Levy   HEPATOLOGY

A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

(2017) Senko Tsukuda et al.   HEPATOLOGY

Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

(2017) Florian A. Lempp et al.   HEPATOLOGY

Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

(2017) Satomi Shimura et al.   JOURNAL OF HEPATOLOGY

Woodchuck sodium taurocholate cotransporting polypeptide supports low-level hepatitis B and D virus entry

(2017) Liran Fu et al.   VIROLOGY

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

(2017) Joanne M. Donkers et al.   Scientific Reports

Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry

(2017) Camillo Sargiacomo et al.   Stem Cell Research & Therapy

A potent human neutralizing antibody Fc-dependently reduces established HBV infections

(2017) Dan Li et al.   eLife

Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells

(2017) Ming Zhou et al.   VIROLOGICA SINICA

In vivomodels of hepatitis B and C virus infection

(2016) Benjamin Y. Winer et al.   FEBS LETTERS

Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance

(2016) Xueqin Chen et al.   INFECTION GENETICS AND EVOLUTION

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B

(2016) Antje Blank et al.   JOURNAL OF HEPATOLOGY

Experimental in vitro and in vivo models for the study of human hepatitis B virus infection

(2016) Lena Allweiss et al.   JOURNAL OF HEPATOLOGY

New therapeutic agents for chronic hepatitis B

(2016) Mayur Brahmania et al.   LANCET INFECTIOUS DISEASES

Experimental models of hepatitis B and C — new insights and progress

(2016) Emmanuel Thomas et al.   Nature Reviews Gastroenterology & Hepatology

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

(2016) Eloi Verrier et al.   Viruses-Basel

Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency

(2016) Mei Deng et al.   Experimental and Therapeutic Medicine

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

(2016) Eloi R. Verrier et al.   Cell Reports

Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na+-dependent taurocholate cotransporting polypeptide activity

(2015) Xue-jun Wang et al.   ANTIVIRAL RESEARCH

The FDA approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

(2015) Chunkyu Ko et al.   ANTIVIRAL THERAPY

Quantitative NTCP pharmacophore and lack of association between DILI and NTCP Inhibition

(2015) Zhongqi Dong et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B

(2015) Hui-Han Hu et al.   GUT

Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure

(2015) Mirjam B Zeisel et al.   GUT

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

The p.Ser267Phe variant inSLC10A1is associated with resistance to chronic hepatitis B

(2015) Liang Peng et al.   HEPATOLOGY

AASLD guidelines for treatment of chronic hepatitis B

(2015) Norah A. Terrault et al.   HEPATOLOGY

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na+-taurocholate cotransporting polypeptide knockout mice

(2015) Davor Slijepcevic et al.   HEPATOLOGY

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

(2015) Eloi R. Verrier et al.   HEPATOLOGY

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

(2015) Manabu Kaneko et al.   JOURNAL OF VIROLOGY

Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013

(2015) Aparna Schweitzer et al.   LANCET

Interleukin 6 inhibits HBV entry through NTCP down regulation

(2015) Fidaa Bouezzedine et al.   VIROLOGY

Animal Models and the Molecular Biology of Hepadnavirus Infection

(2015) W. S. Mason   Cold Spring Harbor Perspectives in Medicine

(−)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes

(2014) Hsiu-Chen Huang et al.   ANTIVIRAL RESEARCH

Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle

(2014) Matthieu Blanchet et al.   ANTIVIRAL RESEARCH

Association of Genetic Variation of Sodium Taurocholate Cotransporting Polypeptide with Chronic Hepatitis B Virus Infection

(2014) Na Li et al.   Genetic Testing and Molecular Biomarkers

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

(2014) Frédéric M. Vaz et al.   HEPATOLOGY

NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry

(2014) Koichi Watashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of Sodium Taurocholate Cotransporting Polypeptide (NTCP) Expression

(2014) Senko Tsukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes

(2014) Alexander König et al.   JOURNAL OF HEPATOLOGY

Strategies for immortalization of primary hepatocytes

(2014) Eva Ramboer et al.   JOURNAL OF HEPATOLOGY

Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide

(2014) H. Yan et al.   JOURNAL OF VIROLOGY

Entry of hepatitis B and C viruses — recent progress and future impact

(2014) Thomas F Baumert et al.   Current Opinion in Virology

The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor

(2013) Gang Yu et al.   BEHAVIOURAL PHARMACOLOGY

Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP

(2013) Masashi Iwamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Discovery of naturally occurring transmissible chronic hepatitis B virus infection among Macaca fascicularis from mauritius island

(2013) Tatiana Dupinay et al.   HEPATOLOGY

Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts

(2013) Alexa Schieck et al.   HEPATOLOGY

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

(2013) Koichi Watashi et al.   HEPATOLOGY

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor

(2013) Shirin Nkongolo et al.   JOURNAL OF HEPATOLOGY

Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide

(2013) H. Yan et al.   JOURNAL OF VIROLOGY

Structural basis of the alternating-access mechanism in a bile acid transporter

(2013) Xiaoming Zhou et al.   NATURE

Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters

(2013) M. Sawkat Anwer et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes

(2012) Julie Lucifora et al.   ANTIVIRAL RESEARCH

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

(2012) Tommy B Andersson et al.   Expert Opinion on Drug Metabolism & Toxicology

A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus A-determinant

(2012) Camille Sureau et al.   HEPATOLOGY

Liver function assessment with three13C breath tests by two-point measurements

(2012) Yukimoto Ishii et al.   ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES

Long-Term 3,5,3′-Triiodothyroacetic Acid Therapy in a Child with Hyperthyroidism Caused by Thyroid Hormone Resistance: Pharmacological Study and Therapeutic Recommendations

(2012) Rie Anzai et al.   THYROID

Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations

(2011) Wei Pan et al.   XENOBIOTICA

Nuclear Receptor Regulation of the Adaptive Response of Bile Acid Transporters in Cholestasis

(2010) Martin Wagner et al.   SEMINARS IN LIVER DISEASE

Differential Regulation of Drug Transporter Expression by Hepatocyte Growth Factor in Primary Human Hepatocytes

(2009) M. Le Vee et al.   DRUG METABOLISM AND DISPOSITION

A Function Essential to Viral Entry Underlies the Hepatitis B Virus "a" Determinant

(2009) J. Salisse et al.   JOURNAL OF VIROLOGY

Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction

(2009) A. Schulze et al.   JOURNAL OF VIROLOGY