Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

(2013) John E. Tavis et al.   PLoS Pathogens

Hepatitis B virus genetic variants: biological properties and clinical implications

(2013) Shuping Tong et al.   Emerging Microbes & Infections

Effectiveness of Hepatitis B Treatment in Clinical Practice

(2012) Steven J. Scaglione et al.   GASTROENTEROLOGY

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ

(2012) Jieliang Chen et al.   HEPATOLOGY

Extensive Mutagenesis of the Conserved Box E Motif in Duck Hepatitis B Virus P Protein Reveals Multiple Functions in Replication and a Common Structure with the Primer Grip in HIV-1 Reverse Transcriptase

(2012) Y.-X. Wang et al.   JOURNAL OF VIROLOGY

Carbonyl J Acid Derivatives Block Protein Priming of Hepadnaviral P Protein and DNA-Dependent DNA Synthesis Activity of Hepadnaviral Nucleocapsids

(2012) Yong-Xiang Wang et al.   JOURNAL OF VIROLOGY

Protein-Primed Terminal Transferase Activity of Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

TP-RT Domain Interactions of Duck Hepatitis B Virus Reverse Transcriptase in cis and in trans during Protein-Primed Initiation of DNA Synthesis In Vitro

(2012) R. K. Boregowda et al.   JOURNAL OF VIROLOGY

Hydrophobic residues of terminal protein domain of hepatitis B virus polymerase contribute to distinct steps in viral genome replication

(2011) Youn-Chul Shin et al.   FEBS LETTERS

A conserved arginine residue in the terminal protein domain of hepatitis B virus polymerase is critical for RNA pre-genome encapsidation

(2011) Y.-C. Shin et al.   JOURNAL OF GENERAL VIROLOGY

A High Level of Mutation Tolerance in the Multifunctional Sequence Encoding the RNA Encapsidation Signal of an Avian Hepatitis B Virus and Slow Evolution Rate Revealed by In Vivo Infection

(2011) B. Schmid et al.   JOURNAL OF VIROLOGY

A Tyr Residue in the Reverse Transcriptase Domain Can Mimic the Protein-Priming Tyr Residue in the Terminal Protein Domain of a Hepadnavirus P Protein

(2011) J. Beck et al.   JOURNAL OF VIROLOGY

Cryptic Protein Priming Sites in Two Different Domains of Duck Hepatitis B Virus Reverse Transcriptase for Initiating DNA Synthesis In Vitro

(2011) R. K. Boregowda et al.   JOURNAL OF VIROLOGY

A SELEX-Screened Aptamer of Human Hepatitis B Virus RNA Encapsidation Signal Suppresses Viral Replication

(2011) Hui Feng et al.   PLoS One

Adenylylation: renaissance of a forgotten post-translational modification

(2011) Aymelt Itzen et al.   TRENDS IN BIOCHEMICAL SCIENCES

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Characterization and Molecular Modeling of Hepatitis B Virus Polymerase Resistance to Entecavir

(2010) Ann W. Walsh et al.   PLoS One

Computational model of hepatitis B virus DNA polymerase: Molecular dynamics and docking to understand resistant mutations

(2010) Pankaj R. Daga et al.   PROTEIN SCIENCE

Proximity between the cap and 5′ ε stem–loop structure is critical for the suppression of pgRNA translation by the hepatitis B viral polymerase

(2010) Dong-Kyun Ryu et al.   VIROLOGY

Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections

(2010) Erik De Clercq et al.   Viruses-Basel

Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

(2010) Haifeng Wang et al.   PLoS Pathogens

RNA-protein interactions in hepadnavirus reverse transcription

(2009) Jianming Hu   Frontiers in Bioscience-Landmark

Hepatitis B Virus Resistance to Nucleos(t)ide Analogues

(2009) Fabien Zoulim et al.   GASTROENTEROLOGY

DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids

(2009) H. Wang et al.   JOURNAL OF VIROLOGY

Incorporation of Eukaryotic Translation Initiation Factor eIF4E into Viral Nucleocapsids via Interaction with Hepatitis B Virus Polymerase

(2009) S. Kim et al.   JOURNAL OF VIROLOGY

Four Conserved Cysteine Residues of the Hepatitis B Virus Polymerase Are Critical for RNA Pregenome Encapsidation

(2009) S. Kim et al.   JOURNAL OF VIROLOGY

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

An interdomain RNA binding site on the hepadnaviral polymerase that is essential for reverse transcription

(2009) Matthew P. Badtke et al.   VIROLOGY

Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model

(2008) Saleem Kamili et al.   HEPATOLOGY

Functional and Structural Dynamics of Hepadnavirus Reverse Transcriptase during Protein-Primed Initiation of Reverse Transcription: Effects of Metal Ions

(2008) L. Lin et al.   JOURNAL OF VIROLOGY

Reverse Transcriptase- and RNA Packaging Signal-Dependent Incorporation of APOBEC3G into Hepatitis B Virus Nucleocapsids

(2008) D. H. Nguyen et al.   JOURNAL OF VIROLOGY

Hepatitis B viruses: Reverse transcription a different way

(2008) Michael Nassal   VIRUS RESEARCH

Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5′ stem–loop structure

(2007) Dong-Kyun Ryu et al.   VIROLOGY