Thienopyridine-Associated Drug-Drug Interactions: Pharmacologic Mechanisms and Clinical Relevance

Pharmacodynamic Evaluation of Pantoprazole Therapy on Clopidogrel Effects

(2011) José Luis Ferreiro et al.   Circulation-Cardiovascular Interventions

Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel

(2011) Ricardo Fontes-Carvalho et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Clopidogrel with or without Omeprazole in Coronary Disease

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

ACCF/AHA Clopidogrel Clinical Alert: Approaches to the FDA “Boxed Warning”

(2010) et al.   CIRCULATION

Comparison Between the Effect of Omeprazole and Rabeprazole on the Antiplatelet Action of Clopidogrel

(2010) Suksiri Siriswangvat et al.   CIRCULATION JOURNAL

Adding Cilostazol to Dual Antiplatelet Therapy Achieves Greater Platelet Inhibition than High Maintenance Dose Clopidogrel in Patients With Acute Myocardial Infarction

(2010) Young-Hoon Jeong et al.   Circulation-Cardiovascular Interventions

Effect of Intrinsic and Extrinsic Factors on the Clinical Pharmacokinetics and Pharmacodynamics of Prasugrel

(2010) David S. Small et al.   CLINICAL PHARMACOKINETICS

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

(2010) D J Angiolillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI

(2010) Jessica L. Mega et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate

(2010) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiovascular Risk in Clopidogrel-Treated Patients According to Cytochrome P450 2C19*2 Loss-of-Function Allele or Proton Pump Inhibitor Coadministration

(2010) Jean-Sébastien Hulot et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

(2010) Neena S. Abraham et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12receptor blockade and inhibition of platelet aggregation after clopidogrel

(2010) H. M. JUDGE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clopidogrel with or without Omeprazole in Coronary Artery Disease

(2010) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The use of amlodipine, but not of P-glycoprotein inhibiting calcium channel blockers is associated with clopidogrel poor-response

(2010) Ankie Harmsze et al.   THROMBOSIS AND HAEMOSTASIS

A randomised determination of the Effect of Fluvastatin and Atorvastatin on top of dual antiplatelet treatment on platelet aggregation after implantation of coronary drug-eluting stents

(2010) Linda Abrecht et al.   THROMBOSIS AND HAEMOSTASIS

Smoking at least 10 cigarettes per day increases platelet inhibition by clopidogrel in patients with ST-segment-elevation myocardial infarction

(2010) Young-Hoon Jeong et al.   THROMBOSIS RESEARCH

Concomitant Use of Clopidogrel and Proton Pump Inhibitors or Cimetidine After Acute Myocardial Infarction Would Increase the Risk of Re-Infarction

(2009) Sophie Sheng-Wen Wang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel

(2009) Jessica L. Mega et al.   CIRCULATION

Smoking, Clopidogrel, and Mortality in Patients With Established Cardiovascular Disease

(2009) Jeffrey S. Berger et al.   CIRCULATION

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

(2009) M. Kazui et al.   DRUG METABOLISM AND DISPOSITION

Predicting the Clinical Relevance of Drug Interactions From Pre-Approval Studies

(2009) Silvio Caccia et al.   DRUG SAFETY

2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update)

(2009) Frederick G. Kushner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interaction Between Cigarette Smoking and Clinical Benefit of Clopidogrel

(2009) Nihar R. Desai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials

(2009) Michelle L O'Donoghue et al.   LANCET

Pharmacology of emerging novel platelet inhibitors

(2008) Dominick J. Angiolillo et al.   AMERICAN HEART JOURNAL

Effects of the Proton Pump Inhibitor Lansoprazole on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel

(2008) David S. Small et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Calcium-Channel Blockers Reduce the Antiplatelet Effect of Clopidogrel

(2008) Jolanta M. Siller-Matula et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE