ACCF/AHA Clopidogrel Clinical Alert: Approaches to the FDA “Boxed Warning”

Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies

(2010) Paul A. Gurbel et al.   CIRCULATION

Combination Antithrombotic Therapies

(2010) Paul A. Gurbel et al.   CIRCULATION

Adding Cilostazol to Dual Antiplatelet Therapy Achieves Greater Platelet Inhibition than High Maintenance Dose Clopidogrel in Patients With Acute Myocardial Infarction

(2010) Young-Hoon Jeong et al.   Circulation-Cardiovascular Interventions

Clopidogrel reloading in patients undergoing percutaneous coronary intervention on chronic clopidogrel therapy: results of the ARMYDA-4 RELOAD (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) randomized trial

(2010) G. Di Sciascio et al.   EUROPEAN HEART JOURNAL

Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation

(2010) Nicoline J. Breet   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Addition of Cilostazol to Aspirin and a Thienopyridine for Prevention of Restenosis After Coronary Artery Stenting: A Meta-Analysis

(2010) Douglas L. Jennings et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Genetic Variation in Metabolizing Enzyme and Transporter Genes: Comprehensive Assessment in 3 Major East Asian Subpopulations With Comparison to Caucasians and Africans

(2010) Michael Man et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effects of Polyunsaturated Omega-3 Fatty Acids on Responsiveness to Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention

(2010) Grzegorz Gajos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study

(2010) Christopher P Cannon et al.   LANCET

Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis

(2010) F Sofi et al.   PHARMACOGENOMICS JOURNAL

Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: A randomized, controlled study

(2009) Yaling Han et al.   AMERICAN HEART JOURNAL

Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial

(2009) Stefan James et al.   AMERICAN HEART JOURNAL

Relation of Cytochrome P450 2C19 Loss-of-Function Polymorphism to Occurrence of Drug-Eluting Coronary Stent Thrombosis

(2009) Betti Giusti et al.   AMERICAN JOURNAL OF CARDIOLOGY

Can We Override Clopidogrel Resistance?

(2009) Ana Pena et al.   CIRCULATION

Intensifying Platelet Inhibition With Tirofiban in Poor Responders to Aspirin, Clopidogrel, or Both Agents Undergoing Elective Coronary Intervention

(2009) Marco Valgimigli et al.   CIRCULATION

Cardiovascular Death and Nonfatal Myocardial Infarction in Acute Coronary Syndrome Patients Receiving Coronary Stenting Are Predicted by Residual Platelet Reactivity to ADP Detected by a Point-of-Care Assay

(2009) Rossella Marcucci et al.   CIRCULATION

Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

(2009) Paul A. Gurbel et al.   CIRCULATION

Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel

(2009) Jessica L. Mega et al.   CIRCULATION

Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention

(2009) D. Sibbing et al.   EUROPEAN HEART JOURNAL

Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial

(2009) Alan D. Michelson et al.   EUROPEAN HEART JOURNAL

Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease

(2009) C. Varenhorst et al.   EUROPEAN HEART JOURNAL

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty

(2009) George Dangas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Randomized Comparison of Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With High Post-Treatment Platelet Reactivity

(2009) Young-Hoon Jeong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pharmacogenetics in Cardiovascular Antithrombotic Therapy

(2009) Francisco Marín et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to cyp 2c19*2 genotype: first experience in patients

(2009) P. A. GURBEL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tailored Clopidogrel Loading Dose According to Platelet Reactivity Monitoring to Prevent Acute and Subacute Stent Thrombosis

(2008) Laurent Bonello et al.   AMERICAN JOURNAL OF CARDIOLOGY

Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation

(2008) Matthew J. Price et al.   EUROPEAN HEART JOURNAL

Clopidogrel 150 mg/day to Overcome Low Responsiveness in Patients Undergoing Elective Percutaneous Coronary Intervention

(2008) Boris Aleil et al.   JACC-Cardiovascular Interventions

Glycoprotein IIb/IIIa Inhibitors Improve Outcome After Coronary Stenting in Clopidogrel Nonresponders

(2008) Thomas Cuisset et al.   JACC-Cardiovascular Interventions

The Antiplatelet Effect of Higher Loading and Maintenance Dose Regimens of Clopidogrel

(2008) Patrick Gladding et al.   JACC-Cardiovascular Interventions

Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance

(2008) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents

(2008) Dietmar Trenk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

(2008) Jean-Philippe Collet et al.   LANCET

Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study

(2008) Yining Huang et al.   LANCET NEUROLOGY

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19⁎2 allele on clopidogrel responsiveness

(2007) Pierre Fontana et al.   THROMBOSIS RESEARCH