Article
Biology
Soeun Kim, Guk-Yeol Park, Jong Seok Park, Jiho Park, Hyebeen Hong, Yoontae Lee
Summary: The transcriptional repressor Capicua (CIC) plays a critical role in controlling thymic selection process, impacting both positive and negative selection of thymocytes. CIC deficiency attenuates TCR signaling in DP cells and regulates multiple genes involved in T cell development, suggesting it serves as a safeguard against autoimmunity.
Review
Biochemistry & Molecular Biology
Kurt Engeland
Summary: RB and p53 are central tumor suppressors that play key roles in regulating the cell division cycle. RB downregulates numerous genes by forming complexes with E2F transcription factors, and its repression is released through phosphorylation. p53 activates CDKN1A gene to regulate RB phosphorylation, leading to expression of cell cycle regulators. There is an overlap between RB and DREAM signaling pathways.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Multidisciplinary Sciences
Laura M. Cowell, Michael King, Helena West, Matthew Broadsmith, Paul Genever, Mary Elizabeth Pownall, Harry V. Isaacs
Summary: The Fgf/Erk/Cic axis plays an important role in Xenopus embryonic development, regulating mesoderm induction and patterning of the anteroposterior axis. Cic protein levels in embryonic cells are affected by Fgf overexpression and ectodermal wounding. Cic knockdown and Fgf overexpression have overlapping effects on embryo development and gene expression.
Article
Hematology
Yasunori Kogure, Takuro Kameda, Junji Koya, Makoto Yoshimitsu, Kisato Nosaka, Jun-ichirou Yasunaga, Yoshitaka Imaizumi, Mizuki Watanabe, Yuki Saito, Yuta Ito, Marni B. McClure, Mariko Tabata, Sumito Shingaki, Kota Yoshifuji, Kenichi Chiba, Ai Okada, Nobuyuki Kakiuchi, Yasuhito Nannya, Ayako Kamiunten, Yuki Tahira, Keiichi Akizuki, Masaaki Sekine, Kotaro Shide, Tomonori Hidaka, Yoko Kubuki, Akira Kitanaka, Michihiro Hidaka, Nobuaki Nakano, Atae Utsunomiya, R. Alejandro Sica, Ana Acuna-Villaorduna, Murali Janakiram, Urvi Shah, Juan Carlos Ramos, Tatsuhiro Shibata, Kengo Takeuchi, Akifumi Takaori-Kondo, Yasushi Miyazaki, Masao Matsuoka, Kenji Ishitsuka, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, B. Hilda Ye, Kazuya Shimoda, Keisuke Kataoka
Summary: Through whole-genome sequencing of 150 ATL cases, we identified the genetic landscape of ATL. We found frequent loss-of-function alterations in the CIC gene, which were previously overlooked. Truncations of the REL gene were also common and found in diffuse large B-cell lymphoma. Recurrent mutations in non-coding regions of driver genes were identified. By combining analyses of coding and noncoding mutations, structural variations, and copy number alterations, we discovered 56 recurrently altered driver genes, including 11 novel ones. ATL cases were classified into 2 molecular groups based on their driver alteration profile.
Article
Anatomy & Morphology
Laura E. Schultz-Rogers, Michelle L. Thayer, Sekhar Kambakam, Wesley A. Wierson, Jordan A. Helmer, Mark D. Wishman, Kristen A. Wall, Jessica L. Greig, Jaimie L. Forsman, Kavya Puchhalapalli, Siddharth Nair, Trevor J. Weiss, Jon M. Luiken, Patrick R. Blackburn, Stephen C. Ekker, Marcel Kool, Maura McGrail
Summary: Background Retinoblastoma binding protein 4 (Rbbp4) plays a crucial role in neural progenitor cell cycle regulation and survival. Loss of Rbbp4 leads to apoptosis and DNA damage in the developing brain. Furthermore, Rbbp4 is involved in cell cycle exit and contributes to neural progenitor survival through the regulation of Tp53 acetylation.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Oncology
Christina Voelkel-Johnson
Summary: The aberrant biology of polyploid giant cancer cells (PGCC) involves dysregulation of the cell cycle, induction of stress responses, and dedifferentiation. Sphingolipids, as an important class of membrane lipids, play crucial roles in polyploidy and the generation of offspring with stem-like properties. This review explores the functions of sphingolipids in embryonic development, cell cycle regulation, and stem cells, aiming to highlight the parallels to polyploidy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Brenna Hourigan, Spencer D. Balay, Graydon Yee, Saloni Sharma, Qiumin Tan
Summary: New neurons continuously arise in the adult hippocampus, but little is known about the factors regulating neuronal differentiation, migration, and dendrite maturation. Our study reveals a previously unrecognized role of the transcriptional repressor protein CIC in adult hippocampal neurogenesis, as its loss impedes neuronal lineage development and disrupts dendritic arborization and migration of adult-born neurons.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Yasuko Tokunaga, Ken-Ichiro Otsuyama, Naoki Hayashida
Summary: Cell cycle regulation involves various factors, including cyclins and CDKs. Heat shock transcription factors (HSFs) play important roles not only in cell protection but also in immediate gene expression during cell cycle progression.
Review
Immunology
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao
Summary: Cell metabolism plays a critical role in regulating T cell development, directing different metabolic pathways and signaling networks to match the specific functional requirements of different stages. Understanding this interplay may offer new therapeutic approaches to selectively regulate T cell subset functions and modulate autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jesus Hernandez-Monge, Mayra Martinez-Sanchez, Adriana Rousset-Roman, Ixaura Medina-Medina, Vanesa Olivares-Illana
Summary: MDM2 regulates cell cycle progression by controlling the synthesis and degradation of RB protein in a cell cycle-specific manner. Under genotoxic stress, MDM2 enhances translation of RB mRNA to induce G1 cell cycle arrest, but ubiquitinates and degrades RB protein in the G2/M phase. The ATM phosphomimetic mutant MDM2(S395D) further confirms that MDM2's effect on RB levels is dependent on DNA damage.
Article
Oncology
Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J. McCann, Talya S. Laufer, Nicolas Gordon, Irina A. Vasilevskaya, Emanuela Dylgjeri, Saswati N. Chand, Matthew J. Schiewer, Josep Domingo-Domenech, Robert B. Den, Jeff Holst, Peter A. McCue, Johann S. de Bono, Christopher McNair, Karen E. Knudsen
Summary: This study identifies the stage-specific consequences of RB loss across cancer progression, which directly impact tumor response to clinically utilized therapeutics. It is the first to investigate the effect of RB loss on global metabolic regulation and link RB/E2F1 to redox control in multiple advanced diseases.
Article
Chemistry, Physical
Peihua Li, Shiming Pu, Chao Lin, Liu He, Hongxia Zhao, Cheng Yang, Ziqi Guo, Shisan Xu, Zuping Zhou
Summary: Curcumin exhibits anti-colon cancer properties by inhibiting cell proliferation and inducing apoptosis through p53-mediated mechanisms.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Microbiology
Lei Qiu, Ze Li, Li Zhang, Tong-Sheng Zhang, Shun-Juan Hu, Ji-Zheng Song, Jia-Hua Liu, Jing Zhang, Juan-Juan Wang, Wen Cheng
Summary: In this study, Beauveria bassiana was used as a biological model to investigate the role of BbTdp1 in entomopathogenic fungi. The findings indicated that BbTdp1 significantly contributed to cell development, the cell cycle, and virulence in B. bassiana. Deletion of BbTdp1 led to drastic fluctuations in the transcriptional profile.
MICROBIOLOGY SPECTRUM
(2021)
Article
Pharmacology & Pharmacy
Miao Zhang, Xiaowen Bi, Shuai Liu, Yu Liu, Qiyu Wang
Summary: This study reveals for the first time that OBS triggers senescence in pituitary cells via the p53-p21-RB signaling pathway. OBS inhibits cell proliferation, induces cell cycle arrest at the G1 phase, and downregulates the expression of key proteins involved in the G1/S transition. This study provides new perspectives for understanding the potential toxicity of OBS.
Article
Oncology
Mirella Baroni, Caihong Yi, Saket Choudhary, Xiufen Lei, Adam Kosti, Denise Grieshober, Mitzli Velasco, Mei Qiao, Suzanne S. Burns, Patricia R. Araujo, Talia DeLambre, Mi Young Son, Michelina Plateroti, Marco A. R. Ferreira, E. Paul Hasty, Luiz O. F. Penalva
Summary: RNA binding protein Msi1 plays a crucial role in glioblastoma by regulating cell cycle and DNA replication genes, impacting tumor growth and response to therapy. High levels of Msi1 are associated with poor prognosis and tumor growth in multiple cancers.