Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Minkai Song, Xiangyu Wang, Jiawen Gao, Weizhou Jiang, Enguang Bi, Taixue An, Ting Wang, Zishuo Chen, Weilu Liu, Zhanjun Shi, Jun Xiao, Chao Zhang
Summary: This study reveals that the increased expression of circular RNA (circRNA) circIFNGR2 in peripheral blood mononuclear cells is associated with the severity of ankylosing spondylitis (AS). In vitro experiments show that circIFNGR2 promotes macrophage proliferation, regulates M1/M2 macrophage polarization and NF-kB/Akt pathways. Furthermore, circIFNGR2 enhances the expression of iNOS/TNFa and M1 polarization, and inhibits M2 polarization by sponging miR-939. The RNA-binding protein eIF4A3 is found to enhance the production of circIFNGR2. Importantly, miR-939 attenuates joint damage in collagen-induced arthritis mice, while circIFNGR2 reverses this effect. These findings highlight the pro-inflammatory roles of eIF4A3-induced circIFNGR2 in AS by modulating macrophage-associated inflammation through miR-939.
Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Di Tian, Yuan Zhou, Yuting Chen, Ye Wu, Heng Wang, Chunchun Jie, Yan Yang, Yaoyao Liu, Haoyu Wang, Dian Zhou
Summary: This study used two-sample Mendelian randomization analysis and found a strong association between ankylosing spondylitis (AS) and psoriasis, with positive causal effects of AS on the risk of psoriasis in the European population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Annapoorna Kuppuswamy
Summary: Chronic fatigue is a significant symptom in various diseases, but there is no unified framework to explain it. This narrative review investigates the role of selective attention in the development of chronic fatigue and discusses results within the sensory attenuation model of fatigue. The findings suggest that poor selective attention is associated with increased levels of chronic fatigue in multiple sclerosis, stroke, traumatic brain injury, and Parkinson's disease. However, there is currently insufficient evidence to determine the direction of causality. Future research should focus on establishing causality and exploring attentional circuitry as a potential therapeutic target.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Siwar Eid, Kassem Sharif, Dennis McGonagle, Yonatan Shneor Patt, Avishai M. Tsur, Mohammad Adawi, Arnon D. Cohen, Howard Amital, Abdulla Watad
Summary: This retrospective study found a higher prevalence of valvular heart diseases, such as aortic stenosis, aortic insufficiency, and mitral insufficiency, in patients with ankylosing spondylitis (AS). The increased risk of these heart valve disorders may be attributed to the inflammatory nature of AS and biomechanical stress on the valvular structures.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Food Science & Technology
Herdis Agovi, Lapo Pierguidi, Caterina Dinnella, Maria Pia Viggiano, Erminio Monteleone, Sara Spinelli
Summary: This study investigated the relationship between the acceptability of vegetables, food neophobia, taste responsiveness, and the attentive responses to vegetables with different sensory properties. The results showed that attention is particularly grabbed by vegetables with unappealing sensory properties, indicating a strong negative correlation between liking scores and attention.
FOOD QUALITY AND PREFERENCE
(2022)
Article
Medicine, General & Internal
Gerhard Schmalz, Markus Bartl, Jan Schmickler, Susann Patschan, Daniel Patschan, Dirk Ziebolz
Summary: This cross-sectional study aimed to investigate the potential associations between periodontal inflamed surface area (PISA) and tooth loss with disease-related parameters in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients. The study found that tooth loss is associated with disease activity, especially in RA individuals, while no associations were found between PISA and disease-related parameters in both groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Qiaochu Li, Zhiyu Chen, Chaohua Yang, Linbang Wang, Jingjin Ma, Tao He, Huanhuan Li, Zhengxue Quan
Summary: The study identifies DDIT3 and HSPB1 as potential therapeutic targets for AS. It suggests that these genes may induce ferroptosis in AS patients' cells through changes in the inflammatory response in the immune microenvironment.
FRONTIERS IN GENETICS
(2022)
Article
Rheumatology
Murat Torgutalp, Valeria Rios Rodriguez, Ani Dilbaryan, Fabian Proft, Mikhail Protopopov, Maryna Verba, Judith Rademacher, Hildrun Haibel, Joachim Sieper, Martin Rudwaleit, Denis Poddubnyy
Summary: This study aimed to analyze the association between treatment with tumour necrosis factor inhibitors (TNFi) and radiographic spinal progression in patients with axial spondyloarthritis (axSpA). The results showed that TNFi treatment in the current 2-year interval was not associated with retardation of radiographic spinal progression, but TNFi treatment in the previous 2-year interval was significantly associated with a reduction of mSASSS progression.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Maria-Sole Chimenti, Rieke Alten, Maria-Antonieta D'Agostino, Elisa Gremese, Uta Kiltz, Ennio Lubrano, Mireia Moreno, Thao Pham, Roberta Ramonda, Francesca-Romana Spinelli, Chiara Perella, Laura Andreoli
Summary: Emerging evidence suggests that axial spondyloarthritis (axSpA) occurs with roughly equal frequency in women and men, but they experience the disease differently. Female patients often face longer diagnostic delays and greater limitations in physical function, leading to lower treatment adherence.
Article
Orthopedics
Dan Huang, Jian Liu, Lei Wan, Yanyan Fang, Yan Long, Ying Zhang, Bingxi Bao
Summary: This study identified several lncRNAs specifically expressed in peripheral blood mononuclear cells of AS patients, indicating their potential key roles in the pathogenesis of this autoimmune disease. Specifically, NONHSAT118801.2 and NONHSAT183847.1 were found to be correlated with disease severity, suggesting their involvement in the occurrence and development of AS.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, Research & Experimental
Huan Li, Liang Wang, Jing Zhu, Jialing Xiao, Huining Yang, Huanyue Hai, Jiarui Hu, Lin Li, Yi Shi, Man Yu, Ping Shuai, Yuping Liu, Xueming Ju, Gang Wu, Yu Zhou, Bolin Deng, Bo Gong
Summary: The study aimed to find reliable serum biomarkers for diagnosing ankylosing spondylitis (AS). Serum samples from 20 AS patients and 20 healthy controls (HCs) were analyzed using UPLC-MS/MS. Differential metabolites between AS patients and HCs were identified, and pathway analysis and heat map were conducted. Predictive and diagnostic models were established using random forest (RF) and LASSO regression. A total of 61 differential metabolites were identified, and RF model showed 95% predictive accuracy and a high AUC. A diagnostic model consisting of nine metabolites was generated, capable of distinguishing HCs from AS with a high AUC. UPLC-MS/MS analysis proved to be a powerful tool for identifying AS metabolite profiles, and the identified biomarkers had diagnostic value for AS.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shanshan Xu, Xiaoyi Zhang, Xinqi Wang, Huimin Xie, Feier Wang, Tingting Zhou, Lingxiang Yu, Shengqian Xu, Faming Pan
Summary: The study explores the association between the methylation level and transcript level of the FOXO3a gene with AS susceptibility. It is found that DNA methylation and transcription of FOXO3a may be related to AS susceptibility and have a crucial role in the diagnosis of AS.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Guohong Jiang, Fei Wang, Fuliang Qi, Ling Zhang
Summary: This study found that the expression level of miR-222-3p is increased in AS patients, and miR-222-3p can serve as a biomarker for diagnosing AS and predicting the therapeutic efficacy of NSAIDs.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Health Care Sciences & Services
Souraya Sidani, Mary Fox, Dana R. Epstein
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2017)
Article
Cell Biology
Nataliya Zlotnikov, Ashkan Javid, Mijhgan Ahmed, Azad Eshghi, Tian Tian Tang, Anoop Arya, Anil Bansal, Fatima Matar, Maitry Parikh, Rhodaba Ebady, Adeline Koh, Nupur Gupta, Peng Song, Yang Zhang, Susan Newbigging, Gary P. Wormser, Ira Schwartz, Robert Inman, Michael Glogauer, Tara J. Moriarty
CELLULAR MICROBIOLOGY
(2017)
Article
Nursing
Souraya Sidani, Dana R. Epstein, Mary Fox, Joyal Miranda
CLINICAL NURSING RESEARCH
(2018)
Review
Rheumatology
Katayoon Bidad, Eric Gracey, Kasey S. Hemington, Josiane C. S. Mapplebeck, Karen D. Davis, Robert D. Inman
NATURE REVIEWS RHEUMATOLOGY
(2017)
Review
Rheumatology
Vidya Ranganathan, Eric Gracey, Matthew A. Brown, Robert D. Inman, Nigil Haroon
NATURE REVIEWS RHEUMATOLOGY
(2017)
Article
Rheumatology
Ahmed Omar, Ismail Sari, Mohamed Bedaiwi, David Salonen, Nigil Haroon, Robert D. Inman
Article
Multidisciplinary Sciences
Yuki Yamashita, Mark Anczurowski, Munehide Nakatsugawa, Makito Tanaka, Yuki Kagoya, Ankit Sinha, Kenji Chamoto, Toshiki Ochi, Tingxi Guo, Kayoko Saso, Marcus O. Butler, Mark D. Minden, Thomas Kislinger, Naoto Hirano
NATURE COMMUNICATIONS
(2017)
Article
Audiology & Speech-Language Pathology
Boaz M. Ben-David, Michal Icht
LANGUAGE AND SPEECH
(2018)
Article
Rheumatology
Malek Faham, Victoria Carlton, Martin Moorhead, Jianbiao Zheng, Mark Klinger, Francois Pepin, Thomas Asbury, Marissa Vignali, Ryan O. Emerson, Harlan S. Robins, James Ireland, Emily Baechler-Gillespie, Robert D. Inman
ARTHRITIS & RHEUMATOLOGY
(2017)
Correction
Rheumatology
J. S. Smolen, M. Schols, J. Braun, Douglas Veale
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Rheumatology
Jonathan Chan, Ismail Sari, David Salonen, Mark S. Silverberg, Nigil Haroon, Robert D. Inman
ARTHRITIS CARE & RESEARCH
(2018)
Article
Rheumatology
Mansour Alazmi, Ismail Sari, Bharath Krishnan, Robert D. Inman, Nigil Haroon
ARTHRITIS CARE & RESEARCH
(2018)
Article
Gerontology
Emily C. King, Veronique M. Boscart, Brett M. Weiss, Tilak Dutta, Jack P. Callaghan, Geoff R. Fernie
JOURNAL OF APPLIED GERONTOLOGY
(2019)
Review
Rheumatology
Desiree van der Heijde, Sofia Ramiro, Robert Landewe, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, Floris van Gaalen, Pal Geher, Irene van der Horst-Bruinsma, Robert D. Inman, Merryn Jongkees, Uta Kiltz, Tore K. Kvien, Pedro M. Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compan, Salih Ozgocmen, Fernando M. Pimentel-Santos, John Reveille, Martin Rudwaleit, Jochen Sieper, Percival Sampaio-Barros, Dieter Wiek, Juergen Braun
ANNALS OF THE RHEUMATIC DISEASES
(2017)
Article
Geriatrics & Gerontology
Hannah M. O'Rourke, Souraya Sidani, Charlene H. Chu, Mary Fox, Katherine S. McGilton, Jhonna Collins
GERONTOLOGY AND GERIATRIC MEDICINE
(2017)