Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

(2013) Y. Saito et al.   Science Translational Medicine

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor

(2012) Lorien J. Parker et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

(2012) Zorik Chilingaryan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound

(2012) Hirofumi Nakano et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Pim-1 Kinase Inhibitor Targeting Residues That Bind the Substrate Peptide

(2012) Keiko Tsuganezawa et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

(2011) Noriko Handa et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Trial by fire: are the crystals macromolecules?

(2010) Kannan Raghunathan et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Cell-permeable Carboxyl-terminal p27Kip1Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

(2010) Daisuke Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragment-Based Cocktail Crystallography by the Medical Structural Genomics of Pathogenic Protozoa Consortium

(2009) Christophe Verlinde et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259

(2008) T Pene-Dumitrescu et al.   ONCOGENE