Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Published 2012 View Full Article
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Title
Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Authors
Keywords
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Journal
Acta Crystallographica Section F-Structural Biology and Crystallization Communications
Volume 68, Issue 8, Pages 860-866
Publisher
International Union of Crystallography (IUCr)
Online
2012-07-31
DOI
10.1107/s1744309112027108
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Note: Only part of the references are listed.- Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound
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- A Novel Pim-1 Kinase Inhibitor Targeting Residues That Bind the Substrate Peptide
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- A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors
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- REFMAC5 for the refinement of macromolecular crystal structures
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- Overview of theCCP4 suite and current developments
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- Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases
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- 7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes
- (2011) Kilian Huber et al. JOURNAL OF MEDICINAL CHEMISTRY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights
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- Cell-permeable Carboxyl-terminal p27Kip1Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase
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- Inhibitors of PIM-1 Kinase: A Computational Analysis of the Binding Free Energies of a Range of Imidazo [1,2-b] Pyridazines
- (2010) Slimane Doudou et al. Journal of Chemical Information and Modeling
- Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration
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- Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode†
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- Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases
- (2009) Zhi-Fu Tao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor
- (2009) Alex N. Bullock et al. PLoS One
- 4-(1H-Indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors
- (2008) Cynthia M. Shafer et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels
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- Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes
- (2008) Jasna Maksimoska et al. CHEMISTRY-A EUROPEAN JOURNAL
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