Review
Biochemistry & Molecular Biology
Hansaem Jang, Yemin Jo, Jung Hyun Lee, Sekyu Choi
Summary: Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue homeostasis and hair growth cycles. This review summarizes our understanding of how age-associated HFSC intrinsic and extrinsic mechanisms can induce HFSC aging and hair loss. In addition, we discuss approaches developed to attenuate age-associated changes in HFSCs and their niches, thereby promoting hair regrowth.
Article
Cell & Tissue Engineering
Pierfrancesco Pagella, Laura de Vargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis
Summary: The Notch signaling pathway plays a crucial role in mediating interactions between perivascular stem cells and their niches in human dental mesenchymal tissues, influencing the response to traumatic injuries in vivo. These stem cells can be modulated by cues from the microenvironment, highlighting the pivotal importance of Notch signaling in tissue homeostasis and regeneration.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Takeshi Motohara, Go J. Yoshida, Hidetaka Katabuchi
Summary: The concept of cancer stem cells has advanced in recent decades, with a focus on their role in tumor heterogeneity and therapeutic resistance. In particular, the interactions between ovarian cancer stem cells and their niches play a key role in chemotherapy resistance in patients with advanced ovarian cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Cell Biology
Anne Brunet, Margaret A. Goodell, Thomas A. Rando
Summary: Stem cell function declines during ageing, resulting in the loss of tissue integrity and health deterioration. This Review discusses the mechanisms underlying ageing in stem cells and their niches, and potential rejuvenation strategies.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Editorial Material
Cell Biology
Louis Gervais, Allison J. Bardin
Summary: The vascular system is a crucial regulator of adult stem cells, as demonstrated by two studies showing that the vascular-like Drosophila trachea undergoes reshaping after intestinal damage or tumor formation, which is necessary for compensatory intestinal stem cell proliferation and tumor growth.
NATURE CELL BIOLOGY
(2021)
Review
Biology
Yanxiao Wang, Nan Tang
Summary: The adult lung, a crucial organ for gas exchange, relies on epithelial stem cells and their interactions with the niche for tissue rejuvenation and regeneration. Advances in single-cell sequencing and other technologies have enhanced our understanding of stem cell characteristics. This review provides an overview of known stem/progenitor cells in different regions of the adult lung and discusses the relationship between dysregulated stem cell function and lung diseases.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Oleg Kandarakov, Alexander Belyaysky, Ekaterina Semenova
Summary: This review discusses various aspects of organization and functioning of the HSC cell niche in bone marrow. The studies include the anatomy of BM niches, various cell types composing the niche, niches for more differentiated cells, metabolism of HSCs in relation to the niche, niche aging, and leukemic transformation of the niche.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Jun Zhou, Michael Boutros
Summary: Tissues like the intestine have versatile stem cells that adjust their functions to a changing environment by receiving signals from their surrounding niche cells. The Drosophila midgut serves as a model for studying stem cell communication with niche cells such as enteroblasts, enterocytes, enteroendocrine cells, and visceral muscles, guiding tissue regeneration and homeostasis. This review explores how distant cells like hemocytes and tracheal cells also impact stem cell development and intestinal diseases, highlighting the importance of stem cell niches in disease progression and conceptual advances derived from the Drosophila intestine as a stem cell model.
CELLS & DEVELOPMENT
(2023)
Article
Ophthalmology
Kirill E. Zhurenkov, Elga I. Alexander-Sinkler, Ilya O. Gavrilyik, Natalia M. Yartseva, Svetlana A. Aleksandrova, Tatiana V. Mashel, Julia I. Khorolskaya, Miralda I. Blinova, Alexei N. Kulikov, Sergei V. Churashov, Valery F. Chernysh, Natalia A. Mikhailova
Summary: This study characterized labial mucosa stem cells (LMSCs) and investigated their potential for corneal epithelial reconstruction. The results showed that LMSCs have significant proliferation and differentiation abilities and do not exhibit detrimental chromosome aberrations. Transplantation of LMSCs promoted corneal epithelial reconstruction and enhanced corneal transparency in a rabbit model of total limbal stem cell deficiency (LSCD).
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Cell Biology
Lili Szabo, Anna C. Seubert, Kai Kretzschmar
Summary: Adult stem cells regulate the homeostasis and regeneration of epithelial tissues. The communication and function of stem cells with their niche as well as diseases can be modelled using epithelial organoid cultures generated from tissue-resident adult stem cells. This has provided unprecedented insights into the biology of epithelial tissues and has become a valuable research tool in various fields.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Linglu Yi, Li Yang
Summary: This review elucidates the important role of stem-like T cells in long-term maintenance of T cell responses and better patient outcomes after immunotherapy. It describes the evolutionary characteristics, mechanism, functions, and implications of T-SL cells. It also discusses the impact of different niches and outlines strategies to generate T-SL cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arvind Konkimalla, Zachary Elmore, Satoshi Konishi, Lauren Macadlo, Hiroaki Katsura, Aleksandra Tata, Aravind Asokan, Purushothama Rao Tata
Summary: This study investigates the targeted delivery of adeno-associated viruses (AAVs) to lung alveolar stem cell niches in mice. AAV5, AAV4, and AAV8 are found to effectively and preferentially transduce alveolar type-2 stem cells (AT2s), endothelial cells, and PDGFRA1 fibroblasts, respectively. The tropism of some AAVs varies depending on the route of administration. Proof-of-concept experiments demonstrate the versatility of AAV5-mediated transgenesis for lineage labeling, cell tracing, and gene inactivation in mouse lungs. AAV6 efficiently transduces both mouse and human AT2s in alveolar organoid cultures. AAV5 and AAV6 can be used for in vivo and ex vivo delivery of guide RNAs and transgene cassettes, respectively, for homologous recombination.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Louis N. Manganas, Irene Dura, Sivan Osenberg, Faith Semerci, Mehmet Tosun, Rachana Mishra, Luke Parkitny, Juan M. Encinas, Mirjana Maletic-Savatic
Summary: This study identified the epitope for the NSC-6 antibody as the signaling protein BASP1, which plays a key role in neurite outgrowth and plasticity. Western blot analysis revealed multiple BASP1 isoforms with varying expression levels, correlating with distinct developmental stages in mouse and human brains. The NSC-6 antibody could be a useful marker for neural stem cells in various developmental stages.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Valentina Granata, Laura Crisafulli, Claudia Nastasi, Francesca Ficara, Cristina Sobacchi
Summary: This article reviews the composition and functionality of the bone marrow niche in normal and malignant conditions, as well as the therapeutic implications of the interplay between its diverse cellular components and malignant cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao, Luana Tomaipitinca, Alma Mansson, Makoto Kondo, Xiaoyan Sun, Anne-Sofie Johansson, Karl Tryggvason, Maria Kasper, Marcus Jaras, Hong Qian
Summary: This study demonstrates the regenerative capacity of AML cells infiltrated in the skin and the role of skin mesenchymal niches in maintaining and protecting AML cells. It provides new insight into the pathology of leukemia cutis and suggests potential implications for AML relapse.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Developmental Biology
Michael J. Johnston, Shaked Bar-Cohen, Ze'ev Paroush, Todd G. Nystul
Article
Cell Biology
Bryne Ulmschneider, Bree K. Grillo-Hill, Marimar Benitez, Dinara R. Azimova, Diane L. Barber, Todd G. Nystul
JOURNAL OF CELL BIOLOGY
(2016)
Article
Genetics & Heredity
Matthew S. Cook, Coralie Cazin, Marc Amoyel, Shinya Yamamoto, Erika Bach, Todd Nystul
Article
Genetics & Heredity
Matthew S. Cook, Coralie Cazin, Marc Amoyel, Shinya Yamamoto, Erika Bach, Todd Nystul
Article
Multidisciplinary Sciences
Sumitra Tatapudy, Marimar Benitez, Todd Nystul
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Developmental Biology
Marimar Benitez, Sumitra Tatapudy, Yi Liu, Diane L. Barber, Todd G. Nystul
DEVELOPMENTAL BIOLOGY
(2019)
Article
Biology
Jocelyne Fadiga, Todd G. Nystul
Review
Biology
Katja Rust, Todd Nystul
CURRENT OPINION IN INSECT SCIENCE
(2020)
Article
Developmental Biology
Sumitra Tatapudy, Jobelle Peralta, Todd Nystul
Summary: In Drosophila ovarian epithelial follicle stem cells, the E2 ubiquitin ligase, Bendless, plays multiple roles in JNK signaling, differentiation, proliferation, and niche competition, with a relationship to hedgehog signaling pathway regulation.
Article
Multidisciplinary Sciences
Yi Liu, Efren Reyes, David Castillo-Azofeifa, Ophir D. Klein, Todd Nystul, Diane L. Barber
Summary: Liu et al. find that intracellular pH dynamics regulate the secretory cell fate decision of intestinal stem cells. They observe an intracellular pH gradient in mouse small intestinal crypts, with the lowest pH in crypt stem cells and increasing along the crypt column. Disrupting this gradient inhibits crypt budding and Paneth cell differentiation, which can be rescued by exogenous WNT. They demonstrate that intracellular pH dynamics acts downstream of ATOH1, with increased pH promoting differentiation toward the secretory lineage. These findings establish a role for intracellular pH dynamics in cell fate decisions within an adult stem cell lineage.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Zhipeng Sun, Todd G. Nystul, Guohua Zhong
Summary: In this study, the researchers used single-cell RNA sequencing, RNAi screen, and bioinformatic analysis to identify genes involved in germ cell differentiation. They discovered that a gene named eggpl is highly expressed in ovarian germline stem cells and downregulated in early daughter cells. Knockdown of eggpl resulted in defects in germ cell proliferation and differentiation. Furthermore, the downregulation of eggpl was found to link nutritional status to germ cell proliferation and differentiation. This study provides new insights into the signaling networks regulating early germ cell development and identifies eggpl as an important player in this process.
Correction
Multidisciplinary Sciences
Katja Rust, Lauren E. Byrnes, Kevin Shengyang Yu, Jason S. Park, Julie B. Sneddon, Aaron D. Tward, Todd G. Nystul
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Katja Rust, Laurean E. Byrnes, Kevin Shengyang Yu, Jason S. Park, Julie B. Sneddon, Aaron D. Tward, Todd G. Nystul
NATURE COMMUNICATIONS
(2020)
Review
Biochemistry & Molecular Biology
Sumitra Tatapudy, Francesca Aloisio, Diane Barber, Todd Nystul
Article
Developmental Biology
Rebecca P. Kim-Yip, Todd G. Nystul