New patented histone deacetylase inhibitors

Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors

(2009) Sukhdev Manku et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2)

(2009) Richard W. Heidebrecht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Histone Deacetylases: A Pharmacological Approach to the Treatment of Non-Cancer Disorders

(2009) Norbert Wiech et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Histone Deacetylase Inhibitors In Inflammatory Disease

(2009) Maria Halili et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel Structural Insights into Class I and II Histone Deacetylases

(2009) Ralf Ficner   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

(2009) Olaf Kinzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epigenetics in cancer: Targeting chromatin modifications

(2009) L. Ellis et al.   MOLECULAR CANCER THERAPEUTICS

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents

(2008) Hong Su et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Mercaptoketone based histone deacetylase inhibitors

(2008) Paul L. Wash et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of a series of potent and selective ketone histone deacetylase inhibitors

(2008) Giovanna Pescatore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)

(2008) Kevin J. Wilson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

(2008) David M. Andrews et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of KD5170: A novel mercaptoketone-based histone deacetylase inhibitor

(2008) Joseph E. Payne et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)

(2008) Joey L. Methot et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors

(2008) Ester Muraglia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfamides as novel histone deacetylase inhibitors

(2008) Amal Wahhab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

(2008) L. Gore et al.   CLINICAL CANCER RESEARCH

Phase I Study of MGCD0103 Given As a Three-Times-Per-Week Oral Dose in Patients With Advanced Solid Tumors

(2008) Lillian L. Siu et al.   JOURNAL OF CLINICAL ONCOLOGY

Histone Deacetylase Inhibitors: From Bench to Clinic

(2008) Marielle Paris et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

(2008) Philip Jones et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Peptide Macrocyclic Histone Deacetylase Inhibitors

(2008) Adegboyega K. Oyelere et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

(2008) C. A. Hassig et al.   MOLECULAR CANCER THERAPEUTICS

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling

(2008) Rentian Feng et al.   MOLECULAR CANCER THERAPEUTICS

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

(2008) M. Fournel et al.   MOLECULAR CANCER THERAPEUTICS

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

(2007) David J. Witter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS