Article
Peripheral Vascular Disease
Dana L. Ruter, Ziqing Liu, Kimlynn M. Ngo, X. Shaka, Allison Marvin, Danielle B. Buglak, Elise J. Kidder, Victoria L. Bautch
Summary: Fluid shear stress from blood flow triggers a transition from active blood vessel expansion to vascular homeostasis, with SMAD6 playing a crucial role in maintaining this balance. SMAD6 functions downstream of Notch signaling and transcription regulation, rescuing flow misalignment induced by Notch loss. Upregulation of PCDH12 by SMAD6 is required for proper endothelial cell alignment in response to flow, placing SMAD6 as a key mediator between Notch1 and PCDH12 during this transition in vessel phenotype.
Article
Acoustics
Asis Lopez, Jenna Osborn, Rachael Irwin, Damir B. Khismatullin, Gregory T. Clement, Matthew R. Myers
Summary: This study investigated the rupture time of microbubbles injected into earthworm vessels under sonication, and confirmed the similar elastic properties between earthworm blood vessels and arteries in older humans. A modified mechanical index (MMI) was defined to capture the trends in rupture probability and rupture time for different parameter values, creating a database of vessel rupture thresholds.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Biology
Danielle B. Buglak, Pauline Bougaran, Molly R. Kulikauskas, Ziqing Liu, Elizabeth Monaghan-Benson, Ariel L. Gold, Allison P. Marvin, Andrew Burciu, Natalie T. Tanke, Morgan Oatley, Shea N. Ricketts, Karina Kinghorn, Bryan N. Johnson, Celia E. Shiau, Stephen Rogers, Christophe Guilluy, Victoria L. Bautch
Summary: Endothelial cells, which line blood vessels, regulate blood vessel formation and the blood-tissue barrier through cell-cell junctions. The nuclear-localized protein SUN1 is found to be responsible for coordinating vascular sprouting and regulating endothelial cell-cell junctions. Loss of SUN1 impairs blood vessel formation, destabilizes junctions, and results in defective cell-cell connections. SUN1 acts through the LINC complex, microtubules, and Rho-regulated contractility to stabilize junctions and promote their function. This long-range regulation is crucial for proper blood vessel sprouting and maintaining junction integrity.
Review
Cell Biology
Can Huang, Dawei Yang, George W. Ye, Charles A. Powell, Peipei Guo
Summary: Canonical Notch signaling is crucial for cell proliferation, differentiation, and fate maintenance in development and cancer, with distinctive roles in hematopoietic stem cell emergence during embryonic development and lineage choices in adult hematopoiesis. Studies continue to debate the necessity of Notch signaling for adult HSC maintenance, urging for more detailed investigations into specific biological contexts to better understand the therapeutic implications of Notch-related pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mario Bauer
Summary: This review summarizes the consequences of GPR15 signaling, focusing on different cell types expressing GPR15 and its ligands, with a particular emphasis on blood and vasculature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Fabienne Podieh, Peter L. Hordijk
Summary: Cullin3-based ubiquitin E3 ligases play a crucial role in regulating cellular functions by inducing ubiquitination of substrates. These ligase complexes primarily target small GTPases of the Rho subfamily, influencing cytoskeletal dynamics and cell adhesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mohsin Raza, Khuram Naveed, Awais Akram, Nema Salem, Amir Afaq, Hussain Ahmad Madni, Mohammad A. U. Khan, Mui-zzud-din
Summary: Deep learning-based medical image analysis is crucial for diagnosing retinal diseases, with a focus on diabetic retinopathy (DR). DR diagnosis can be aided by analyzing the creation of new vessels and swelling in retinal blood vessels as biomarkers for screening and analysis.
Review
Biochemistry & Molecular Biology
Nathalie Tisch, Carmen Ruiz de Almodovar
Summary: The formation of new blood vessels involves proliferation of endothelial cells and vessel sprout elongation, along with vessel remodeling and regression to adapt vessel density. Recent studies focus on how vessel regression and cell death contribute to this process, challenging the simplistic view of cell death machinery as only promoting cellular demise. This review highlights the role of cell death signaling pathways, particularly apoptosis and necroptosis, in blood vessel formation during development and pathology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Kirill Salewskij, Josef M. Penninger
Summary: Despite advances, cardiovascular disorders remain a major threat to global health, with one-third of global deaths attributed to these disorders. Species-specific pathways and a lack of high-throughput methods often limit research on new therapeutics and their effects on vascular parameters. In vitro models for human blood vessels are challenging due to the complex 3-dimensional environment, cellular crosstalk, and organ-specific architectures. Recently, self-organizing human capillary blood vessel organoids have been developed, which recapitulate key processes of vasculogenesis, angiogenesis, and diabetic vasculopathy, and have been used as models for other diseases.
CIRCULATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kurschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Geraud, Sergij Goerdt, Philipp-Sebastian Koch
Summary: This study established an HHT mouse model with liver vascular malformations and investigated the role of ALK1 signaling in liver vessel formation and metabolic function. The results showed that hepatic endothelial ALK1 signaling protects from development of vascular malformations and preserves organ-specific endothelial differentiation and angiocrine signaling.
Article
Biochemistry & Molecular Biology
Ivy K. N. Chiang, Matthew S. Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood, Keyi Jiang, Bitong Li, Yew Yan Wong, Mehdi Moustaqil, Emmanuelle Lesieur, Renae Skoczylas, Valerie Kouskoff, Jan Kazenwadel, Luis Arriola-Martinez, Emma Sierecki, Yann Gambin, Kari Alitalo, Friedmann Kiefer, Natasha L. Harvey, Mathias Francois
Summary: SOX7, a BEC-specific transcription factor, modulates the expression level of angiocrine signals in blood vascular endothelial cells (BECs) to pattern lymphatic vessels. It directly represses the transcription of Vegfc, a major lymphangiogenic growth factor, and interacts with HEY1 to regulate Notch pathway. Our finding reveals the importance of SOX7 in modulating downstream signaling events crucial for lymphatic patterning.
Review
Genetics & Heredity
Zuohua Chi, Liji Chen, Xiaomin Ye, Aimei Liu, Gongwang Yu, Yan Sun
Summary: Endothelial cells and perivascular cells together form a diverse network of blood vessels in the bone marrow, facilitating the delivery of blood cells, oxygen, and nutrients. These vessels create niches for hematopoietic stem and progenitor cells, providing signals for cell homing, self-renewal, and differentiation. Understanding the structure and function of the bone marrow vasculature niche is essential for developing advanced strategies in hematopoiesis reconstitution.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biology
Wade W. Sugden, Trista E. North
Summary: Specialized subsets of endothelial cells in different organs and regions of the vascular tree carry out unique functions, with a population of hemogenic endothelial cells transforming into hematopoietic stem cells in embryos. Recent advances in the zebrafish model have uncovered factors facilitating hemogenic commitment and the transition to blood stem cells, such as biomechanical influences and metabolic cues. Transcriptomic-based approaches have revealed key signals in the embryonic niche that regulate hematopoiesis.
Article
Hematology
Muhammad Elnaggar, Anjud Al-Mohannadi, Waseem Hasan, Doua Abdelrahman, Mohammed J. Al-Kubaisi, Igor Pavlovski, Giusy Gentilcore, Abbirami Sathappan, Dhanya Kizhakayil, Aesha I. Ali, Suruchi Mohan, Damilola Olagunju, Chiara Cugno, Jean-Charles Grivel, Chiara Borsotti, Antonia Follenzi, Sahar I. Da'as, Sara Deola
Summary: Emerging gene therapy clinical trials test the correction of hemophilia A (HA) by replacing factor VIII (FVIII) in autologous hematopoietic stem cells (HSCs). This study provides a comprehensive map of FVIII production in different blood lineages and demonstrates the potential of transgene-carrying monocytes to correct HA phenotype in a zebrafish model.
Article
Cell Biology
Sara Menegatti, Bethany Potts, Eva Garcia-Alegria, Roberto Paredes, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Summary: The study reveals the sequential expression of the two RUNX1 isoforms during human blood specification, with RUNX1b marking endothelial cells with hemogenic potential and determining hemogenic competency in a dose-dependent manner. The findings establish RUNX1b isoform as the earliest known marker for hemogenic competency.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)