Altered GABA Signaling in Early Life Epilepsies

The diuretic bumetanide decreases autistic behaviour in five infants treated during 3 months with no side effects

(2010) Eric Lemonnier et al.   ACTA PAEDIATRICA

GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

(2010) Richard W. Olsen et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Reorganization of Inhibitory Synaptic Circuits in Rodent Chronically Injured Epileptogenic Neocortex

(2010) X. Jin et al.   CEREBRAL CORTEX

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits

(2010) Doris D. Wang et al.   CEREBRAL CORTEX

Generalized Convulsive Status Epilepticus in Adults and Children: Treatment Guidelines and Protocols

(2010) Peter Shearer et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

Impaired maturation of cortical GABAA receptor expression in pediatric epilepsy

(2010) Laura A. Jansen et al.   EPILEPSIA

Frameshift mutations of the ARX gene in familial Ohtahara syndrome

(2010) Mitushiro Kato et al.   EPILEPSIA

Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009

(2010) Anne T. Berg et al.   EPILEPSIA

Controversies in epilepsy: Debates held during the Fourth International Workshop on Seizure Prediction

(2010) Mark G. Frei et al.   EPILEPSY & BEHAVIOR

Altered Function of theSCN1AVoltage-gated Sodium Channel Leads to γ-Aminobutyric Acid-ergic (GABAergic) Interneuron Abnormalities

(2010) Melinda S. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABAAReceptor α1 Subunit Mutation A322D Associated with Autosomal Dominant Juvenile Myoclonic Epilepsy Reduces the Expression and Alters the Composition of Wild Type GABAAReceptors

(2010) Li Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockout of GAD65 has Major Impact on Synaptic GABA Synthesized from Astrocyte-Derived Glutamine

(2010) Anne B Walls et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

(2010) Anne B. Walls et al.   JOURNAL OF NEUROCHEMISTRY

Slow Degradation and Aggregation In Vitro of Mutant GABAA Receptor  2(Q351X) Subunits Associated with Epilepsy

(2010) J.-Q. Kang et al.   JOURNAL OF NEUROSCIENCE

Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy

(2010) C. Brandt et al.   JOURNAL OF NEUROSCIENCE

A Single Seizure Episode Leads to Rapid Functional Activation of KCC2 in the Neonatal Rat Hippocampus

(2010) S. Khirug et al.   JOURNAL OF NEUROSCIENCE

Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

(2010) V. I. Dzhala et al.   JOURNAL OF NEUROSCIENCE

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in GABAAreceptor subunits associated with genetic epilepsies

(2010) Robert L. Macdonald et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin

(2010) H. Pruss et al.   NEUROLOGY

Epileptic hypersynchrony revisited

(2010) Doru Georg Margineanu   NEUROREPORT

Oxytocin is neuroprotective against oxygen–glucose deprivation and reoxygenation in immature hippocampal cultures

(2010) Mihai Ceanga et al.   NEUROSCIENCE LETTERS

Mutations affecting GABAergic signaling in seizures and epilepsy

(2010) Aristea S. Galanopoulou   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Medical Treatment of Pediatric Status Epilepticus

(2010) Nicholas S. Abend et al.   Seminars in Pediatric Neurology

Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females

(2009) Eric Marsh et al.   BRAIN

Presynaptic plasticity: targeted control of inhibitory networks

(2009) Chris J McBain et al.   CURRENT OPINION IN NEUROBIOLOGY

The multifaceted role of inhibition in epilepsy: seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy

(2009) Edward O Mann et al.   CURRENT OPINION IN NEUROLOGY

Bumetanide inhibits rapid kindling in neonatal rats

(2009) Andréy Mazarati et al.   EPILEPSIA

Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex

(2009) Elena Isaeva et al.   EPILEPSY RESEARCH

Decreased Seizure Activity in a Human Neonate Treated With Bumetanide, an Inhibitor of the Na+-K+-2Cl- Cotransporter NKCC1

(2009) Kristopher T. Kahle et al.   JOURNAL OF CHILD NEUROLOGY

De novo SCN1A mutations in Dravet syndrome and related epileptic encephalopathies are largely of paternal origin

(2009) S. E. Heron et al.   JOURNAL OF MEDICAL GENETICS

Bumetanide, an NKCC1 Antagonist, Does Not Prevent Formation of Epileptogenic Focus but Blocks Epileptic Focus Seizures in Immature Rat Hippocampus

(2009) Romain Nardou et al.   JOURNAL OF NEUROPHYSIOLOGY

A Triplet Repeat Expansion Genetic Mouse Model of Infantile Spasms Syndrome, Arx(GCG)10+7, with Interneuronopathy, Spasms in Infancy, Persistent Seizures, and Adult Cognitive and Behavioral Impairment

(2009) M. G. Price et al.   JOURNAL OF NEUROSCIENCE

The GABRG2 Mutation, Q351X, Associated with Generalized Epilepsy with Febrile Seizures Plus, Has Both Loss of Function and Dominant-Negative Suppression

(2009) J.-Q. Kang et al.   JOURNAL OF NEUROSCIENCE

Flumazenil Administration Attenuates Cognitive Impairment in Immature Rats after Controlled Cortical Impact

(2009) Pawel G. Ochalski et al.   JOURNAL OF NEUROTRAUMA

A model of symptomatic infantile spasms syndrome

(2009) Morris H. Scantlebury et al.   NEUROBIOLOGY OF DISEASE

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat

(2009) O. Chudomel et al.   NEUROSCIENCE

The role of neuronal GABAA receptor subunit mutations in idiopathic generalized epilepsies

(2009) L.M. Dibbens et al.   NEUROSCIENCE LETTERS

Hyperglycosylation and Reduced GABA Currents of Mutated GABRB3 Polypeptide in Remitting Childhood Absence Epilepsy

(2008) Miyabi Tanaka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Developmental impact of a familial GABAAreceptor epilepsy mutation

(2008) Cindy Chiu et al.   ANNALS OF NEUROLOGY

Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining

(2008) Lian Wang et al.   BRAIN RESEARCH

Long-term expressional changes of Na+–K+–Cl− co-transporter 1 (NKCC1) and K+–Cl− co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE)

(2008) Xiubin Li et al.   BRAIN RESEARCH

Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS)

(2008) Charlotte D'Hulst et al.   BRAIN RESEARCH

GABAA Receptors in Normal Development and Seizures: Friends or Foes?

(2008) Aristea Galanopoulou   Current Neuropharmacology

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus

(2008) Lei Zhu et al.   EPILEPSY RESEARCH

Sexually dimorphic expression of KCC2 and GABA function

(2008) Aristea S. Galanopoulou   EPILEPSY RESEARCH

SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus

(2008) Huihui Sun et al.   JOURNAL OF HUMAN GENETICS

Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus

(2008) H. P. Goodkin et al.   JOURNAL OF NEUROSCIENCE

GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation

(2008) D. D. Wang et al.   JOURNAL OF NEUROSCIENCE

Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons

(2008) A. Shulga et al.   JOURNAL OF NEUROSCIENCE

Dissociated Gender-Specific Effects of Recurrent Seizures on GABA Signaling in CA1 Pyramidal Neurons: Role of GABAA Receptors

(2008) A. S. Galanopoulou   JOURNAL OF NEUROSCIENCE

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model

(2007) Volodymyr I. Dzhala et al.   ANNALS OF NEUROLOGY

GABAB receptors role in cell migration and positioning within the ventromedial nucleus of the hypothalamus

(2007) K.M. McClellan et al.   NEUROSCIENCE