Journal
EPILEPSY RESEARCH
Volume 87, Issue 2-3, Pages 286-289Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2009.09.011
Keywords
Early seizures; GABA; Somatosensory cortex
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Funding
- NIH (NINDS) [NS041595]
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Here we studied the long-term effects of neonatal seizures on inhibitory synaptic transmission in somatosensory cortex. We found that recurrent flurothyl-induced seizures result in a marked reduction in amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) and increases of miniature IPSCs interevent intervals. These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism. (C) 2009 Elsevier B.V. All rights reserved.
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