Review
Nanoscience & Nanotechnology
Aysel Tomak, Selin Cesmeli, Bercem D. Hanoglu, David Winkler, Ceyda Oksel Karakus
Summary: Proteins in biological fluids rapidly coat the surfaces of pristine nanoparticles forming a protein corona, which modulates their biological responses. Nanoparticle characteristics influence the composition of the protein corona, affecting biological activity, cellular uptake, biodistribution, and drug delivery.Understanding the formation and impact of the protein corona is crucial for nanoparticle-based applications.
Article
Chemistry, Multidisciplinary
Mahdi Tavakol, Mohammad Javad Hajipour, Maryam Ferdousi, Steven Zanganeh, Lionel Maurizi
Summary: The retention time of nanoparticles in the blood circulation system is influenced by the protein corona components, particularly immunoglobulins and serum albumin. Understanding the competition and orientation of proteins on nanoparticle surfaces is essential for studying their behavior in the body.
Review
Biotechnology & Applied Microbiology
Yang Xuan, Wenliang Zhang, Xinjiang Zhu, Shubiao Zhang
Summary: Nanoparticles (NPs) have great potential for early cancer diagnosis and treatment. The nanotechnology industry is rapidly developing, with a wide range of multifunctional NPs in preclinical and clinical stages. Understanding the interactions between NPs and biological systems is crucial, considering their effects on plasma proteins, tumor cells, and small molecules. This review summarizes the impact of NPs' size, shape, chemical composition, and surface modification on their biological effects, including cellular uptake mechanisms, oxidative stress response, and protein interactions. The findings not only support the development of safer and more efficient NPs but also provide a foundation for their clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Analytical
Jing Wang, Jiaoyue Cong, Jin Wu, Yizhuo Chen, Huiyu Fan, Xiaoli Wang, Zhenghua Duan, Lei Wang
Summary: Nanoplastics in the environment can form protein corona by adsorbing biomolecules onto their surfaces, which greatly impacts their biological fate and toxicity. This article summarizes recent progress in understanding the formation, influencing factors, and characterization methods of nanoplastic-protein corona complexes. The unique physio-chemical characteristics of nanoplastics, such as polymerization morphology and functional group modification, are investigated to differentiate them from other nanomaterials. The influences and mechanisms of protein corona formation on nanoplastic toxicity, including cellular uptake and alteration of protein structure and function, are discussed. Suggestions for further research are also proposed. Overall, this study emphasizes the significant role of protein corona in determining the biological characteristics of nanoplastics in realistic nano-ecotoxicological assessments.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Yalin Cong, Didar Baimanov, Yunlong Zhou, Chunying Chen, Liming Wang
Summary: Inorganic nanomaterials (INMs) have attractive applications in biomedical fields, but their delivery is hindered by biological barriers. The structure and components of biological barriers, as well as the physicochemical properties of INMs, contribute to their penetration capacity.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Food Science & Technology
Guoxin Cui, Wentao Su, Mingqian Tan
Summary: The protein corona formed on nanoparticles in food has significant impact on the properties of nanoparticles, protein structure and function, and subsequent biological reactions. These effects include transport, cellular uptake, cytotoxicity, and immune response of nanoparticles. Understanding the effects of protein corona is crucial for evaluating the fate of food-related nanoparticles and controlling nanotoxicity.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Yanni Yu, Yaning Luan, Wei Dai
Summary: This review summarizes the recent research on the dynamic process and mechanisms of protein corona formation, which occurs when nanoparticles interact with proteins. The formation of protein corona is a homeostasis process where proteins compete for limited surface sites on nanoparticles. The review also discusses the factors that affect formation and techniques commonly used for protein corona analysis. Furthermore, it assesses the limitations and challenges in protein corona studies and proposes future perspectives.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Environmental Sciences
Yanni Yu, Wei Dai, Yaning Luan
Summary: The application of nanomaterials in agriculture promotes their interactions with plants. Recently, there has been increasing attention on these interactions and their biological effects. Nanoparticles enter plants through various organs and form biocoronas by adsorbing biomolecules. In addition, when nanoparticles enter plants through roots, they may form ecocoronas with root exudates before contacting plant exogenous proteins. The biological effects of plant protein coronas include changes in protein structure and function, as well as changes in nanoparticle toxicity and targeting ability. However, further investigation is needed to understand the mechanisms, particularly how protein corona affects plant protein function, plant development and growth, and rhizosphere environment properties. This review provides an overview of the formation and biological effects of nanoparticle-plant protein coronas and suggests future research directions.
ENVIRONMENTAL POLLUTION
(2023)
Review
Environmental Sciences
Lokeshwari Natarajan, M. Annie Jenifer, Amitava Mukherjee
Summary: Recent studies have highlighted the significant impact of nanosized materials, particularly plastics, on aquatic ecosystems, with biofilms playing a crucial role in the existence and implications of these pollutants. The binding of Extracellular Polymeric Substances (EPS) forms an eco-corona on these particles, altering their density and surface charge. Understanding the interactions of algal EPS with pollutants and their impact on toxicity is essential for mitigating the environmental effects of these materials.
ENVIRONMENTAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yi Cao
Summary: The interaction between biological molecules and nanomaterials is crucial for understanding the behavior of nanomaterials in complex microenvironments. The formation of nutrient molecule corona alters the uptake of nutrient molecules and/or nanomaterials, and induces combined toxicity through signaling pathways. The structure of nutrient molecules and physicochemical properties of nanomaterials play a key role in the formation of nutrient molecule corona.
Review
Chemistry, Multidisciplinary
Ana Fuentes-Cervantes, Julia Ruiz Allica, Francisco Calderon Celis, Jose M. Costa-Fernandez, Jorge Ruiz Encinar
Summary: The use of nanomaterials in biological systems and their interaction with proteins to form biological corona complexes have great potential in nanobiomedicine but also raise toxicological concerns. Characterizing the protein corona complex is challenging and often requires a combination of techniques. Although inductively coupled plasma mass spectrometry (ICP-MS) is a powerful quantitative technique for nanomaterial characterization, its application in nanoparticle-protein corona studies is limited. However, recent advancements in ICP-MS, particularly in protein quantification through sulfur detection, suggest its potential as a complementary method for characterizing and quantifying the nanoparticle-protein corona complex.
Review
Biochemistry & Molecular Biology
Rakesh Kumar Mishra, Anas Ahmad, Akshay Vyawahare, Pravej Alam, Tajdar Hussain Khan, Rehan Khan
Summary: The formation of protein corona has significant implications on various attributes of nanomaterials based medicinal and drug carrier systems, influencing their fate in vivo and in vitro. This interaction significantly impacts the pharmacological, toxicological, and carrier characteristics of nanoparticles, with effects on biocompatibility traits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Fabio Vianello, Alessandro Cecconello, Massimiliano Magro
Summary: Nanotechnology is aimed at developing intelligent nanomaterials capable of recognizing biological components, with a common belief that coatings are necessary for their application in biological systems. Interdisciplinary research in recent decades has explored the interactions between uncoated inorganic materials and biological systems, emphasizing the role of nanomaterial surface coatings in the biological environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Sonia Panico, Sara Capolla, Sara Bozzer, Giuseppe Toffoli, Michele Dal Bo, Paolo Macor
Summary: Nanoparticles (NPs) have unique physicochemical properties but face challenges in their medical applications due to immune recognition and clearance. This review focuses on intrinsic and extrinsic factors related to NP structure and protein corona formation in vitro. It also discusses the role of antibodies and opsonins in detecting NPs by immune cells. Strategies to reduce protein corona formation are also discussed.
Review
Chemistry, Multidisciplinary
Yuan Liu, Junqing Wang, Qingqing Xiong, Daniel Hornburg, Wei Tao, Omid C. Farokhzad
Summary: Understanding the interactions between nanomaterials and biological systems is crucial for improving the efficacy of nanomedicine and advancing disease diagnosis. The nanoparticle-protein corona has a decisive effect on the in vivo fate of nanomedicine and can be used to enrich low-abundance proteins for biomarker discovery.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Haruhiko Kamada, Shintaro Taki, Kazuya Nagano, Masaki Inoue, Daisuke Ando, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Oncology
Kazuya Nagano, Sunao Imai, Xiluli Zhao, Takuya Yamashita, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Shinsaku Nakagawa, Yasuo Tsutsumi, Shin-Ichi Tsunoda
INTERNATIONAL JOURNAL OF ONCOLOGY
(2015)
Article
Cell Biology
Masaki Inoue, Haruhiko Kamada, Yasuhiro Abe, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda
JOURNAL OF CELL SCIENCE
(2015)
Article
Toxicology
Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi
PARTICLE AND FIBRE TOXICOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Kazuya Nagano, Takuya Yamashita, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Chemistry, Multidisciplinary
Kazuya Nagano, Yuka Maeda, So-ichiro Kanasaki, Takanobu Watanabe, Takuya Yamashita, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda
JOURNAL OF CONTROLLED RELEASE
(2014)
Article
Nanoscience & Nanotechnology
Takashi Nagano, Kazuma Higashisaka, Akiyoshi Kunieda, Yuki Iwahara, Kota Tanaka, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Yasuo Tsutsumi
Article
Multidisciplinary Sciences
Shintaro Taki, Haruhiko Kamada, Masaki Inoue, Kazuya Nagano, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda
Editorial Material
Pharmacology & Pharmacy
Shin-ichi Tsunoda
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2013)
Article
Nanoscience & Nanotechnology
Shunji Imai, Yasuo Yoshioka, Yuki Morishita, Tokuyuki Yoshida, Miyuki Uji, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Kazuma Higashisaka, Yasuo Tsutsumi
NANOSCALE RESEARCH LETTERS
(2014)
Article
Nanoscience & Nanotechnology
Tokuyuki Yoshida, Yasuo Yoshioka, Hideki Takahashi, Kazuki Misato, Takahide Mori, Toshiro Hirai, Kazuya Nagano, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi
NANOSCALE RESEARCH LETTERS
(2014)
Article
Oncology
Kazuya Nagano, So-ichiro Kanasaki, Takuya Yamashita, Yuka Maeda, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda
Article
Chemistry, Medicinal
T. Yamashita, H. Kamada, S. Kanasaki, Y. Maeda, K. Nagano, Y. Abe, M. Inoue, Y. Yoshioka, Y. Tsutsumi, S. Katayama, M. Inoue, S. Tsunoda
Article
Chemistry, Medicinal
K. Yamashita, Y. Yoshioka, H. Pan, M. Taira, T. Ogura, T. Nagano, M. Aoyama, K. Nagano, Y. Abe, H. Kamada, S. -I. Tsunoda, H. Aoshima, H. Nabeshi, T. Yoshikawa, Y. Tsutsumi