Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines

Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?

(2018) Lucija Tomljenovic   JOURNAL OF ALZHEIMERS DISEASE

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Macrophagic myofasciitis and vaccination: Consequence or coincidence?

(2014) Tânia Santiago et al.   RHEUMATOLOGY INTERNATIONAL

Slow CCL2-dependent translocation of biopersistent particles from muscle to brain

(2013) Zakir Khan et al.   BMC Medicine

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

(2013) Heriberto Lima Jr. et al.   CELL CYCLE

Anti-Saccharomyces cerevisiae Autoantibodies in Autoimmune Diseases: from Bread Baking to Autoimmunity

(2013) Maurizio Rinaldi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Selective Elevation of Circulating CCL2/MCP1 Levels in Patients with Longstanding Post-vaccinal Macrophagic Myofasciitis and ASIA

(2013) Josette Cadusseau et al.   CURRENT MEDICINAL CHEMISTRY

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep

(2013) Lluís Luján et al.   IMMUNOLOGIC RESEARCH

Identification of beryllium-dependent peptides recognized by CD4+T cells in chronic beryllium disease

(2013) Michael T. Falta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinctive clinical features in arthro-myalgic patients with and without aluminum hydroxyde-induced macrophagic myofasciitis: An exploratory study

(2013) Nilusha Ragunathan-Thangarajah et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes

(2013) C.A. Shaw et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Kinetics of the inflammatory response following intramuscular injection of aluminum adjuvant

(2013) Fangjia Lu et al.   VACCINE

Control of antigen-binding to aluminum adjuvants and the immune response with a novel phosphonate linker

(2013) Fangjia Lu et al.   VACCINE

Myoinjury transiently activates muscle antigen-specific CD8+ T cells in lymph nodes in a mouse model

(2012) Hua Liao et al.   ARTHRITIS AND RHEUMATISM

Chronic fatigue syndrome and subsequent risk of cancer among elderly US adults

(2012) Cindy M. Chang et al.   CANCER

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

(2012) Tirth R. Ghimire et al.   IMMUNOLOGY LETTERS

Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice

(2012) Xuan-Yi Wang et al.   IMMUNOLOGY LETTERS

Detection of human papillomavirus (HPV) L1 gene DNA possibly bound to particulate aluminum adjuvant in the HPV vaccine Gardasil®

(2012) Sin Hang Lee   JOURNAL OF INORGANIC BIOCHEMISTRY

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Clinical Utility of LC3 and p62 Immunohistochemistry in Diagnosis of Drug-Induced Autophagic Vacuolar Myopathies: A Case-Control Study

(2012) Han S. Lee et al.   PLoS One

To forge a solid immune recognition

(2012) Yan Shi   Protein & Cell

Aluminum Vaccine Adjuvants: Are they Safe?

(2011) L. Tomljenovic et al.   CURRENT MEDICINAL CHEMISTRY

Antigen depot is not required for alum adjuvanticity

(2011) Sharon Hutchison et al.   FASEB JOURNAL

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

The Common Immunogenic Etiology of Chronic Fatigue Syndrome: From Infections to Vaccines via Adjuvants to the ASIA Syndrome

(2011) Hemda Rosenblum et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF)

(2011) Elodie Passeri et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

The next decade of vaccines: societal and scientific challenges

(2011) E Richard Moxon et al.   LANCET

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants

(2010) Roberto Spreafico et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

‘ASIA’ – Autoimmune/inflammatory syndrome induced by adjuvants

(2010) Yehuda Shoenfeld et al.   JOURNAL OF AUTOIMMUNITY

The immunobiology of aluminium adjuvants: how do they really work?

(2010) Christopher Exley et al.   TRENDS IN IMMUNOLOGY

Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury

(2009) Madly Brigitte et al.   ARTHRITIS AND RHEUMATISM

The –928 G/C and –362 G/C Single-Nucleotide Polymorphisms in the Promoter of MCP-1: Increased Transcriptional Activity and Novel Binding Sites

(2009) Paul Nyquist et al.   CEREBROVASCULAR DISEASES

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration

(2009) Christopher A. Shaw et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

(2009) Maryline Couette et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Vaccines and autoimmunity

(2009) Nancy Agmon-Levin et al.   Nature Reviews Rheumatology

Polyglandular autoimmunity with macrophagic myofasciitis

(2008) Brett J. Theeler et al.   CLINICAL RHEUMATOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression

(2008) Bin Li et al.   IMMUNOLOGY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pivotal Advance: Eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production

(2008) H.-B. Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome

(2008) Christopher Exley et al.   MEDICAL HYPOTHESES

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood

(2008) Y. Mikaeloff et al.   NEUROLOGY