The Ins and Outs of B Cells in Multiple Sclerosis

B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity

(2015) Klaus Lehmann-Horn et al.   ANNALS OF NEUROLOGY

The role of fractalkine (CX3CL1) in regulation of CD4+ cell migration to the central nervous system in patients with relapsing–remitting multiple sclerosis

(2015) Kevin Blauth et al.   CLINICAL IMMUNOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis

(2015) Martina Absinta et al.   NEUROLOGY

CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis

(2015) Zafar Mahmood et al.   ARTHRITIS RESEARCH & THERAPY

Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke

(2014) Nancy L Monson et al.   Journal of Neuroinflammation

Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

(2014) R Mancuso et al.   Multiple Sclerosis Journal

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses

(2013) Jaishree Bankoti et al.   ANNALS OF NEUROLOGY

Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models

(2012) Yukio Takeshita et al.   IMMUNOLOGICAL REVIEWS

B cell exchange across the blood-brain barrier in multiple sclerosis

(2012) H.-Christian von Büdingen et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation

(2012) Markus C Kowarik et al.   Journal of Neuroinflammation

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis

(2011) Laura Lovato et al.   BRAIN

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

B cells undergo unique compartmentalized redistribution in multiple sclerosis

(2011) Jürgen Haas et al.   JOURNAL OF AUTOIMMUNITY

CX3CR1 drives cytotoxic CD4+CD28− T cells into the brain of multiple sclerosis patients

(2011) Bieke Broux et al.   JOURNAL OF AUTOIMMUNITY

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

(2011) Birgit Obermeier et al.   JOURNAL OF NEUROIMMUNOLOGY

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

CXCL13 Blockade Disrupts B Lymphocyte Organization in Tertiary Lymphoid Structures without Altering B Cell Receptor Bias or Preventing Diabetes in Nonobese Diabetic Mice

(2010) R. A. Henry et al.   JOURNAL OF IMMUNOLOGY

Clinical study on CXCL13, CCL17, CCL20 and IL-17 as immune cell migration navigators in relapsing−remitting multiple sclerosis patients

(2010) Alicja Kalinowska-Łyszczarz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Chemokine CXCL13 Is a Prognostic Marker in Clinically Isolated Syndrome (CIS)

(2010) Johannes Brettschneider et al.   PLoS One

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial

(2009) Kathleen Hawker et al.   ANNALS OF NEUROLOGY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis☆

(2009) Elizabeth M. Cameron et al.   JOURNAL OF NEUROIMMUNOLOGY

Meningeal Inflammation is not Associated With Cortical Demyelination in Chronic Multiple Sclerosis

(2009) Evert-Jan Kooi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis

(2009) Luca Muzio et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS

(2009) F. Sellebjerg et al.   NEUROLOGY

Homogeneity of active demyelinating lesions in established multiple sclerosis

(2008) Esther C. W. Breij et al.   ANNALS OF NEUROLOGY

CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome

(2008) Jeffrey L. Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis

(2008) Birgit Obermeier et al.   NATURE MEDICINE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE