The Non-Obese Diabetic Mouse Strain as a Model to Study CD8+ T Cell Function in Relapsing and Progressive Multiple Sclerosis

A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation

(2015) Ana C. Anderson et al.   JOURNAL OF AUTOIMMUNITY

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells

(2014) Ming-Hong Lin et al.   CLINICAL IMMUNOLOGY

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

Relapsing-Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells

(2014) K. Sasaki et al.   JOURNAL OF IMMUNOLOGY

Cytokine production profiles in chronic relapsing–remitting experimental autoimmune encephalomyelitis: IFN-γ and TNF-α are important participants in the first attack but not in the relapse

(2014) Yoshihiko Hidaka et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis

(2014) Dagmara Weronika Wojkowska et al.   MEDIATORS OF INFLAMMATION

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet

(2013) A. P. R. Sutherland et al.   JOURNAL OF IMMUNOLOGY

Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges

(2013) Klaus Lehmann-Horn et al.   Therapeutic Advances in Neurological Disorders

Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?

(2012) Jack Antel et al.   ACTA NEUROPATHOLOGICA

A Transgenic Model of Central Nervous System Autoimmunity Mediated by CD4+ and CD8+ T and B Cells

(2012) A. C. Anderson et al.   JOURNAL OF IMMUNOLOGY

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

Contrasting Roles for CD4 vs. CD8 T-Cells in a Murine Model of Virally Induced “T1 Black Hole” Formation

(2012) Istvan Pirko et al.   PLoS One

Revealing the genetic basis of multiple sclerosis: are we there yet?

(2011) Sergio E Baranzini   CURRENT OPINION IN GENETICS & DEVELOPMENT

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice

(2011) Sue M. Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords

(2010) Géraldine Androdias et al.   ANNALS OF NEUROLOGY

Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models

(2010) Lennart T. Mars et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of brain lesions in a mouse model of progressive multiple sclerosis

(2010) H. Levy et al.   EXPERIMENTAL NEUROLOGY

Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

(2010) Hong Pham et al.   JOURNAL OF NEUROIMMUNOLOGY

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

(2010) Qingyong Ji et al.   NATURE IMMUNOLOGY

Pathogenic CD8+T cells in multiple sclerosis

(2009) Manuel A. Friese et al.   ANNALS OF NEUROLOGY

Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice

(2009) Jennifer L. Berard et al.   GLIA

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes mellitus and multiple sclerosis: common etiological features

(2009) Adam E. Handel et al.   Nature Reviews Endocrinology

Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells

(2009) P. Kivisakk et al.   NEUROLOGY

Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment

(2009) Ida S. Haussleiter et al.   Therapeutic Advances in Neurological Disorders

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis

(2008) Alexandre S. Basso et al.   JOURNAL OF CLINICAL INVESTIGATION

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF

(2008) C MALMESTROM et al.   JOURNAL OF NEUROIMMUNOLOGY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY