Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Li Li, Yinglu Wang, Zhengjun Huang, Zuxian Xu, Ruipin Cao, Jiaxin Li, Biyi Wu, Jian Ren Lu, Hu Zhu
Summary: In this study, a hydrogel was developed that can be generated in situ and has remarkable antibacterial and anti-inflammatory activity for treating bacterial-infected wounds. The hydrogel is able to self-heal and sustainably release an antibacterial peptide, while also regulating immune responses. It showed superior activity in terms of bacterial inhibition, inflammation reduction, wound closure, and tissue regeneration in a methicillin-resistant Staphylococcus aureus (MRSA)-infected skin wound model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Nurzynska, Katarzyna Klimek, Agnieszka Michalak, Katarzyna Dos Santos Szewczyk, Marta Arczewska, Urszula Szalaj, Mariusz Gagos, Grazyna Ginalska
Summary: This study aimed to evaluate the potential of biomaterials based on curdlan, a natural biopolymer, modified with hop compounds for promoting skin wound healing. The results showed that these biomaterials had excellent biocompatibility and wound healing-promoting properties without cytotoxic effects on cells and tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Hanif Haidari, Richard Bright, Xanthe L. Strudwick, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: This study presents the development of a multifunctional thermo-responsive hydrogel utilizing ultra-small silver nanoparticles for controlled and optimized delivery of silver to infected wounds. The developed hydrogel showed significant elimination of S. aureus from mouse wounds, promoting cell proliferation and wound re-epithelization. The multifunctional properties of the AgNP thermoresponsive hydrogel offer great clinical potential in controlling bacterial infections and promoting wound healing.
ACTA BIOMATERIALIA
(2021)
Review
Immunology
Meirong Li, Qian Hou, Lingzhi Zhong, Yali Zhao, Xiaobing Fu
Summary: The review highlights the persistent hyper-inflammation as a distinguishing characteristic of chronic wounds, with macrophage malfunction identified as a major contributor. The study explores the origin, heterogeneity, and dysregulation of macrophages in wound healing, while also evaluating therapeutic approaches for restoring macrophage response. Multidimensional analysis using high-throughput technologies helps assess the diversity, activation states, and communication of macrophages in healing and non-healing wounds, providing promising interventions for chronic wounds.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Dalibor Mijaljica, Fabrizio Spada, Daniel J. J. Klionsky, Ian P. P. Harrison
Summary: As a highly regulated and dynamic intracellular degradation mechanism, autophagy plays an essential role in skin wound healing at different stages. It operates at different levels and is modulated based on the conditions of wound healing, contributing to rapid and efficient healing. Enhancing autophagy through the localized application of pro-autophagy biologics, such as hydrogels, can provide moisture and immune modulation, creating a conducive environment for skin wound healing.
Review
Cell Biology
Alireza Hassanshahi, Mohammad Moradzad, Saman Ghalamkari, Moosa Fadaei, Allison J. Cowin, Mohammadhossein Hassanshahi
Summary: This review discusses the role and mechanisms of macrophages in skin wound healing, including cellular and molecular aspects such as subtypes, metabolism, plasticity, and epigenetics. The interactions between macrophages and factors important for wound healing are also highlighted.
Article
Microbiology
Fateme Abedini, Shahla Roudbar Mohammadi, Mostafa Dahmardehei, Marjan Ajami, Maryam Salimi, Halala Khalandi, Monireh Mohsenzadegan, Farhad Seif, Bahador Nikoueian Shirvan, Sanaz Yaalimadad, Maryam Roudbary, Celia F. Rodrigues
Summary: Beta-glucan ointment has efficacy in burn wound healing and has a significant impact on IL-4 levels.
Article
Biochemistry & Molecular Biology
Xiaosu Huang, Junhua Yang, Renyue Zhang, Lianbao Ye, Ming Li, Weiqiang Chen
Summary: Globally, wound infection, particularly bacterial infections like MRSA, poses a significant healthcare challenge. This study demonstrates that PD hydrogel may be a safe and effective treatment option for MRSA-infected wounds, improving wound healing, reducing inflammation, and decreasing bacterial load.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Nayanika Chakraborty, Diksha Jha, Vijay Pal Singh, Pradeep Kumar, Navin Kumar Verma, Hemant Kumar Gautam, Indrajit Roy
Summary: This article presents the preparation and antibacterial efficacy of chitosan-coated Prussian blue nanoparticles loaded with the photosensitizer fluorescein isothiocyanate-dextran (CHPB-FD). The nanoparticles effectively eradicate drug-resistant bacteria and promote wound healing in both in vitro and in vivo experiments. The presence of white light further enhances the antibacterial efficacy of CHPB-FD nanoparticles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Maria Leonia da Costa Gonzaga, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Renata Ferreira de Carvalho Leita, Maria Elenir Nobre Pinho Ribeiro
Summary: This study investigated the potential of polysaccharides from Agaricus blazei Murill mushroom (PAbs) as wound dressings. The results showed that PAbs had no significant impact on the viability of human neutrophils in a concentration range of 1-100 μg mL-1. Moreover, PAbs improved the mechanical properties, thickness, and water vapor permeation of the films, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Yaling Yu, Huimin Xiao, Guoke Tang, Hongshu Wang, Junjie Shen, Yi Sun, Shuaiqun Wang, Wei Kong, Yimin Chai, Xuanzhe Liu, Xing Wang, Gen Wen
Summary: A light-sensitive decellularized dermal extracellular matrix-derived hydrogel was developed, which exhibited fast gelling performance, biomimetic porous microstructure, and abundant bioactive functions. In vivo experiments demonstrated that this hydrogel significantly promoted skin wound healing, improved tissue and collagen expression, and enhanced angiogenesis. Furthermore, the hydrogel facilitated the transition of macrophage phenotype from M1 to M2, contributing to skin regeneration. Thus, this decellularized dermal matrix-derived bioactive hydrogel shows promise for clinical translation in the treatment of cutaneous wound healing.
MATERIALS TODAY BIO
(2023)
Review
Environmental Sciences
Pooya M. Tehrany, Parham Rahmanian, Aryan Rezaee, Golnaz Ranjbarpazuki, Farima Sohrabi Fard, Yasaman Asadollah Salmanpour, Mohammad Arad Zandieh, Ali Ranjbarpazuki, Sajedeh Asghari, Nazanin Javani, Noushin Nabavi, Amir Reza Aref, Mehrdad Hashemi, Mohsen Rashidi, Afshin Taheriazam, Alireza Motahari, Kiavash Hushmandi
Summary: Hydrogels have diverse biomedical uses and can expedite wound healing by improving inflammation, promoting cell growth, inhibiting bacterial infection, and triggering angiogenesis. Smart hydrogels with responsiveness to external stimuli and environmentally friendly hydrogels show promising potential in wound healing.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Tiantian Wu, Hong Wang, Run Tian, Shuang Guo, Yuhui Liao, Jianbing Liu, Baoquan Ding
Summary: In this study, a DNA origami-based bactericide was developed for efficient treatment of infected wounds by organizing DNAzymes and broad-spectrum antibiotics, promoting healing process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen
Summary: Emodin can improve diabetic wound healing by promoting extracellular matrix synthesis and granulation tissue formation, and promote the conversion of M1-like macrophages to M2-like macrophages by down-regulating the NF-xB signaling pathway. This study identified potential targets of emodin and revealed its role in fibroblast proliferation and ECM formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)