Natural killer cells and their receptors in multiple sclerosis

Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors

(2012) W. Jiang et al.   GENOME RESEARCH

Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)

(2012) Pascal F Durrenberger et al.   Journal of Neuroinflammation

Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses

(2012) E. Narni-Mancinelli et al.   SCIENCE

NKG2D receptor regulates human effector T-cell cytokine production

(2011) A. Barber et al.   BLOOD

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research

(2011) N Shenker et al.   BRITISH JOURNAL OF CANCER

Regulation of immune cell function and differentiation by the NKG2D receptor

(2011) Biljana Zafirova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Natural killer cell phenotype and clinical response to interferon-beta therapy in multiple sclerosis

(2011) J.E. Martínez-Rodríguez et al.   CLINICAL IMMUNOLOGY

Anti-CD25 (daclizumab) monoclonal antibody therapy in relapsing–remitting multiple sclerosis

(2011) Roland Martin   CLINICAL IMMUNOLOGY

The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis

(2011) Bernd C. Kieseier   CNS DRUGS

Identity, regulation andin vivofunction of gut NKp46+RORγt+and NKp46+RORγt−lymphoid cells

(2011) Ana Reynders et al.   EMBO JOURNAL

CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease

(2011) Min Fang et al.   IMMUNITY

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

(2011) Kerry S. Campbell et al.   IMMUNOLOGY

Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells

(2011) Isabell Hamann et al.   IMMUNOLOGY

Impaired IFN-γ production and proliferation of NK cells in Multiple Sclerosis

(2011) Anna Lünemann et al.   INTERNATIONAL IMMUNOLOGY

Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)

(2011) Hao Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KIR/HLA Interactions and Pathogen Immunity

(2011) Khaleel M. Jamil et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6

(2011) Yili Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44

(2011) B. Rosental et al.   JOURNAL OF IMMUNOLOGY

Recognition and Killing of Human and Murine Pancreatic   Cells by the NK Receptor NKp46

(2011) C. Gur et al.   JOURNAL OF IMMUNOLOGY

Maternal KIR and fetal HLA-C: a fine balance

(2011) Olympe Chazara et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recent insights into the mechanism of action of glatiramer acetate

(2011) Mrinalini Kala et al.   JOURNAL OF NEUROIMMUNOLOGY

Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: post-hoc and subset analyses of clinical efficacy outcomes

(2011) Alasdair J Coles et al.   LANCET NEUROLOGY

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

(2011) Julian P. Vivian et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Intrathecal effects of daclizumab treatment of multiple sclerosis

(2011) B. Bielekova et al.   NEUROLOGY

LILRA3 Binds Both Classical and Non-Classical HLA Class I Molecules but with Reduced Affinities Compared to LILRB1/LILRB2: Structural Evidence

(2011) Myongchol Ryu et al.   PLoS One

Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site

(2011) M. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm

(2010) Helena Batoulis et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation

(2010) Junwei Hao et al.   ANNALS OF NEUROLOGY

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2

(2010) S. Sivori et al.   BLOOD

Natural killer cells and cancer: Regulation by the killer cell Ig-like receptors (KIR)

(2010) Amanda K. Purdy et al.   CANCER BIOLOGY & THERAPY

Natural Killer Cell Education and Tolerance

(2010) Mark T. Orr et al.   CELL

Natural killer receptors distribution in multiple sclerosis: Relation to clinical course and interferon-beta therapy

(2010) J.E. Martínez-Rodríguez et al.   CLINICAL IMMUNOLOGY

Mechanism of regulation of autoimmunity by iNKT cells

(2010) Jan Novak et al.   CYTOKINE

Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population

(2010) Nicole Marquardt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B-cell targeted therapies in human autoimmune diseases: an updated perspective

(2010) Michael J. Townsend et al.   IMMUNOLOGICAL REVIEWS

Immune memory redefined: characterizing the longevity of natural killer cells

(2010) Joseph C. Sun et al.   IMMUNOLOGICAL REVIEWS

Activating and inhibitory receptors of natural killer cells

(2010) Hollie J Pegram et al.   IMMUNOLOGY AND CELL BIOLOGY

Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment

(2010) Nathalie T. Joncker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment

(2010) Julie M. Elliott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Central nervous system (CNS)–resident natural killer cells suppress Th17 responses and CNS autoimmune pathology

(2010) Junwei Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two HLA class I genes independently associated with multiple sclerosis

(2010) Jenny Link et al.   JOURNAL OF NEUROIMMUNOLOGY

KIRs and their HLA ligands in Remitting–Relapsing Multiple Sclerosis

(2010) Caterina Fusco et al.   JOURNAL OF NEUROIMMUNOLOGY

Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis

(2010) Ernst-Wilhelm Radue et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta

(2010) Daniel Wynn et al.   LANCET NEUROLOGY

HLA B*44: Protective effects in MS susceptibility and MRI outcome measures

(2010) B. C. Healy et al.   NEUROLOGY

Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2

(2010) J. W. Leavenworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis

(2009) Åslaug R. Lorentzen et al.   ANNALS OF NEUROLOGY

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Regulatory T Cells Are Reduced During Anti-CD25 Antibody Treatment of Multiple Sclerosis

(2009) Unsong Oh et al.   ARCHIVES OF NEUROLOGY

Effect of Anti-CD25 Antibody Daclizumab in the Inhibition of Inflammation and Stabilization of Disease Progression in Multiple Sclerosis

(2009) Bibiana Bielekova et al.   ARCHIVES OF NEUROLOGY

Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus

(2009) Yong-Wook Park et al.   ARTHRITIS AND RHEUMATISM

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors

(2009) C. Fauriat et al.   BLOOD

Modulation of natural killer cell cytotoxicity and cytokine release by the drug glatiramer acetate

(2009) K. L. Sand et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Leukocyte Immunoglobulin-Like Receptors as New Players in Autoimmunity

(2009) Rachel Thomas et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hidden talents of natural killers: NK cells in innate and adaptive immunity

(2009) Megan A. Cooper et al.   EMBO REPORTS

Alternative mRNA splicing creates transcripts encoding soluble proteins from mostLILRgenes

(2009) Des C. Jones et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HLA-class I markers and multiple sclerosis susceptibility in the Italian population

(2009) L Bergamaschi et al.   GENES AND IMMUNITY

Multiple sclerosis associates with LILRA3 deletion in Spanish patients

(2009) D Ordóñez et al.   GENES AND IMMUNITY

Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex

(2009) James A. Traherne et al.   HUMAN MOLECULAR GENETICS

Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells

(2009) Katie J. Anderson et al.   IMMUNOLOGY

Splenic natural killer cell activity in two models of experimental neurodegenerative diseases

(2009) Yassin Al-Falahi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

(2009) Thorsten Graef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

(2009) Cameron S. Brandt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

(2009) Wei Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crystal Structure of Myeloid Cell Activating Receptor Leukocyte Ig-like Receptor A2 (LILRA2/ILT1/LIR-7) Domain Swapped Dimer: Molecular Basis for Its Non-binding to MHC Complexes

(2009) Yong Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis

(2009) Arthur A. Vandenbark et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon β-1b

(2009) Mark A Jensen et al.   Multiple Sclerosis Journal

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

The activating receptor NKp46 is essential for the development of type 1 diabetes

(2009) Chamutal Gur et al.   NATURE IMMUNOLOGY

Invariant NKT cells inhibit development of the Th17 lineage

(2009) L. T. Mars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-induced memory-like natural killer cells

(2009) Megan A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

(2009) et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cell education: not an on-off switch but a tunable rheostat

(2009) Petter Brodin et al.   TRENDS IN IMMUNOLOGY

NK cells in autoimmunity: A two-edg'd weapon of the immune system

(2008) Roberto Perricone et al.   AUTOIMMUNITY REVIEWS

Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1

(2008) M. Stern et al.   BLOOD

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

(2008) Philip L. De Jager et al.   BRAIN

Killers and beyond: NK-cell-mediated control of immune responses

(2008) Christopher E. Andoniou et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Soluble MHC class I chain-related protein B serum levels correlate with disease activity in relapsing–remitting multiple sclerosis

(2008) Juan Luís Fernández-Morera et al.   HUMAN IMMUNOLOGY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

The extended human leukocyte receptor complex: diverse ways of modulating immune responses

(2008) Alexander David Barrow et al.   IMMUNOLOGICAL REVIEWS

Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells

(2008) Nathalie T. Joncker et al.   IMMUNOLOGICAL REVIEWS

CD56brightnatural killer (NK) cells: an important NK cell subset

(2008) Aurélie Poli et al.   IMMUNOLOGY

Tolerance of NK cells encountering their viral ligand during development

(2008) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Continuous engagement of a self-specific activation receptor induces NK cell tolerance

(2008) Sandeep K. Tripathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

(2008) Emma J. Petrie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subtle Changes in Peptide Conformation Profoundly Affect Recognition of the Non-Classical MHC Class I Molecule HLA-E by the CD94–NKG2 Natural Killer Cell Receptors

(2008) Hilary L. Hoare et al.   JOURNAL OF MOLECULAR BIOLOGY

Innate Immune-Mediated Neuronal Injury Consequent to Loss of Astrocytes

(2008) Peter J. Darlington et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing—remitting multiple sclerosis

(2008) E. Fainardi et al.   Multiple Sclerosis Journal

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recruitment of Activation Receptors at Inhibitory NK Cell Immune Synapses

(2008) Nicolas Schleinitz et al.   PLoS One

Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease

(2008) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Yin and Yang of HLA and KIR in human disease

(2008) Smita Kulkarni et al.   SEMINARS IN IMMUNOLOGY

A critical look at HLA-G

(2008) Richard Apps et al.   TRENDS IN IMMUNOLOGY

Genetic Control of Variegated KIR Gene Expression: Polymorphisms of the Bi-Directional KIR3DL1 Promoter Are Associated with Distinct Frequencies of Gene Expression

(2008) Hongchuan Li et al.   PLoS Genetics

The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells

(2007) N. T. Young et al.   BLOOD