Biomaterial-mediated strategies targeting vascularization for bone repair

Effects of hydroxyapatite on endothelial network formation in collagen/fibrin composite hydrogels in vitro and in vivo

(2014) Rameshwar R. Rao et al.   Acta Biomaterialia

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

(2014) Olaia F. Vila et al.   Acta Biomaterialia

Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment

(2014) Elisabeth Seebach et al.   Acta Biomaterialia

Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle

(2014) Asha Shekaran et al.   BIOMATERIALS

Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2

(2014) Marian H. Hettiaratchi et al.   BIOMATERIALS

Fabrication, vascularization and osteogenic properties of a novel synthetic biomimetic induced membrane for the treatment of large bone defects

(2014) Liling Ren et al.   BONE

Sensing rigidity

(2014) José R. García et al.   NATURE MATERIALS

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

Enhanced Healing of Rat Calvarial Defects with MSCs Loaded on BMP-2 Releasing Chitosan/Alginate/Hydroxyapatite Scaffolds

(2014) Xiaoning He et al.   PLoS One

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

CXCL12/Stromal-Cell-Derived Factor-1 Effectively Replaces Endothelial Progenitor Cells to Induce Vascularized Ectopic Bone

(2014) Rhandy M. Eman et al.   STEM CELLS AND DEVELOPMENT

Influence of Mesenchymal Stem Cells with Endothelial Progenitor Cells in Co-culture on Osteogenesis and Angiogenesis: An In Vitro Study

(2013) Qiong Li et al.   ARCHIVES OF MEDICAL RESEARCH

Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes

(2013) Edward A. Phelps et al.   BIOMATERIALS

Enhancement of bone regeneration by dual release of a macrophage recruitment agent and platelet-rich plasma from gelatin hydrogels

(2013) Yang-Hee Kim et al.   BIOMATERIALS

Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays

(2013) Eric H. Nguyen et al.   BIOMATERIALS

Bone regeneration potential of allogeneic or autogeneic mesenchymal stem cells loaded onto cancellous bone granules in a rabbit radial defect model

(2013) Soo-Hwan Kang et al.   CELL AND TISSUE RESEARCH

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

Cell-based approaches to the engineering of vascularized bone tissue

(2013) Rameshwar R. Rao et al.   CYTOTHERAPY

Angiogenesis and intramembranous osteogenesis

(2013) Christopher J. Percival et al.   DEVELOPMENTAL DYNAMICS

Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells

(2013) Sandra A Jacobs et al.   IMMUNOLOGY AND CELL BIOLOGY

Localized delivery of growth factors for angiogenesis and bone formation in tissue engineering

(2013) Yan Bai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Prevascularisation with endothelial progenitor cells improved restoration of the architectural and functional properties of newly formed bone for bone reconstruction

(2013) Hao Pang et al.   INTERNATIONAL ORTHOPAEDICS

Adipose tissue-derived mesenchymal stem cells as monocultures or cocultures with human umbilical vein endothelial cells: Performance in vitro and in rat cranial defects

(2013) Jinling Ma et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Delivery of S1P receptor-targeted drugs via biodegradable polymer scaffolds enhances bone regeneration in a critical size cranial defect

(2013) Anusuya Das et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor

(2013) Thi H. Nguyen et al.   Nature Chemistry

Effects of Vascular Endothelial Growth Factor 165 on Bone Tissue Engineering

(2013) Lin Feng et al.   PLoS One

Oxygen-releasing biomaterials for tissue engineering

(2013) Gulden Camci-Unal et al.   POLYMER INTERNATIONAL

Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis

(2013) Anthony O. Awojoodu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Osteogenesis in Cocultures with Human Mesenchymal Stem Cells and Endothelial Cells on Polymeric Microfiber Scaffolds

(2013) Julia G. Gershovich et al.   TISSUE ENGINEERING PART A

Osteogenic and angiogenic potentials of monocultured and co-cultured human-bone-marrow-derived mesenchymal stem cells and human-umbilical-vein endothelial cells on three-dimensional porous beta-tricalcium phosphate scaffold

(2012) Yunqing Kang et al.   Acta Biomaterialia

Gene therapy approaches to regenerating bone

(2012) Nadav Kimelman Bleich et al.   ADVANCED DRUG DELIVERY REVIEWS

Matrix composition regulates three-dimensional network formation by endothelial cells and mesenchymal stem cells in collagen/fibrin materials

(2012) Rameshwar R. Rao et al.   ANGIOGENESIS

Experimental research Adenovirus-mediated transfer of VEGF into marrow stromal cells combined with PLGA/TCP scaffold increases vascularization and promotes bone repair in vivo

(2012) Chunguang Duan et al.   Archives of Medical Science

Reciprocal induction of human dermal microvascular endothelial cells and human mesenchymal stem cells: time-dependent profile in a co-culture system

(2012) M. S. Laranjeira et al.   CELL PROLIFERATION

Endothelial Progenitor Cells Improve Directly and Indirectly Early Vascularization of Mesenchymal Stem Cell-Driven Bone Regeneration in a Critical Bone Defect in Rats

(2012) C. Seebach et al.   CELL TRANSPLANTATION

Melatonin promotes angiogenesis during repair of bone defects: a radiological and histomorphometric study in rabbit tibiae

(2012) María Piedad Ramírez-Fernández et al.   Clinical Oral Investigations

Effects of recombinant human bone morphogenic protein-2 and human bone marrow-derived stromal cells onin vivobone regeneration of chitosan-poly(ethylene oxide) hydrogel

(2012) Seongyeon Jo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Experimental repair of segmental bone defects in rabbits by angiopoietin-1 gene transfected MSCs seeded on porous β-TCP scaffolds

(2012) Le Cao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells

(2012) N. Hu et al.   JOURNAL OF CELL SCIENCE

Synthetic hydrogel scaffold is an effective vehicle for delivery of INFUSE (rhBMP2) to critical-sized calvaria bone defects in rats

(2012) Peter D. Mariner et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effects of endothelial cells on proliferation and survival of human mesenchymal stem cells and primary osteoblasts

(2012) Dominik Steiner et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Endothelial cells stimulate osteogenic differentiation of mesenchymal stem cells on calcium phosphate scaffolds

(2012) Ulrike Bulnheim et al.   Journal of Tissue Engineering and Regenerative Medicine

The contribution of bone to whole-organism physiology

(2012) Gérard Karsenty et al.   NATURE

Dual Delivery of Hepatocyte and Vascular Endothelial Growth Factors via a Protease-Degradable Hydrogel Improves Cardiac Function in Rats

(2012) Apoorva S. Salimath et al.   PLoS One

Endothelial Differentiation of Mesenchymal Stromal Cells

(2012) Karolina Janeczek Portalska et al.   PLoS One

Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

(2012) E. Pedraza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Adipose Tissue-Derived Osteogenic and Endothelial Cells on Bone Allograft Osteogenesis and Vascularization in Critical-Sized Calvarial Defects

(2012) Agustin Cornejo et al.   TISSUE ENGINEERING PART A

Ischemia Is the Prime but Not the Only Cause of Human Multipotent Stromal Cell Death in Tissue-Engineered Constructs In Vivo

(2012) Pierre Becquart et al.   TISSUE ENGINEERING PART A

A Differential Effect of Bone Morphogenetic Protein-2 and Vascular Endothelial Growth Factor Release Timing on Osteogenesis at Ectopic and Orthotopic Sites in a Large-Animal Model

(2012) Ruth E. Geuze et al.   TISSUE ENGINEERING PART A

Covalently tethered transforming growth factor beta in PEG hydrogels promotes chondrogenic differentiation of encapsulated human mesenchymal stem cells

(2012) Joshua D. McCall et al.   Drug Delivery and Translational Research

Vascularization is the key challenge in tissue engineering

(2011) Esther C. Novosel et al.   ADVANCED DRUG DELIVERY REVIEWS

In vitro osteogenesis of human adipose-derived stem cells by coculture with human umbilical vein endothelial cells

(2011) Jian Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reconstruction of integrin activation

(2011) F. Ye et al.   BLOOD

Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis

(2011) G. Cheng et al.   BLOOD

Treatment of long bone defects and non-unions: from research to clinical practice

(2011) Arne Berner et al.   CELL AND TISSUE RESEARCH

Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

(2011) H Karvinen et al.   GENE THERAPY

Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation

(2011) Grace L. Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Assessing the Permeability of Engineered Capillary Networks in a 3D Culture

(2011) Stephanie J. Grainger et al.   PLoS One

Mechanical regulation of vascular growth and tissue regeneration in vivo

(2011) J. D. Boerckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing

(2011) M. M. Martino et al.   Science Translational Medicine

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

(2011) Eugene J. Carragee et al.   Spine Journal

Endothelial Progenitor Cells: Current Issues on Characterization and Challenging Clinical Applications

(2011) Thomas Resch et al.   Stem Cell Reviews and Reports

Concise Review: Circulating Endothelial Progenitor Cells for Vascular Medicine

(2011) Takayuki Asahara et al.   STEM CELLS

Endothelialized biomaterials for tissue engineering applications in vivo

(2011) Omar F. Khan et al.   TRENDS IN BIOTECHNOLOGY

FGF-2 and VEGF functionalization of starPEG–heparin hydrogels to modulate biomolecular and physical cues of angiogenesis

(2010) Andrea Zieris et al.   BIOMATERIALS

Biomimetic hydrogels with pro-angiogenic properties

(2010) James J. Moon et al.   BIOMATERIALS

The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720

(2010) Caren E. Petrie Aronin et al.   BIOMATERIALS

Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration

(2010) Jennifer Patterson et al.   BIOMATERIALS

Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair

(2010) Yufang Shi et al.   CELL RESEARCH

Survival and function of mesenchymal stem cells (MSCs) depend on glucose to overcome exposure to long-term, severe and continuous hypoxia

(2010) M. Deschepper et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Bridging the gap: Bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects

(2010) Marcus Jäger et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Human Adipose Derived Stromal Cells Heal Critical Size Mouse Calvarial Defects

(2010) Benjamin Levi et al.   PLoS One

Bioartificial matrices for therapeutic vascularization

(2010) Edward A. Phelps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human stem cell delivery for treatment of large segmental bone defects

(2010) Kenneth M. Dupont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered vascularized bone grafts

(2010) Olga Tsigkou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear stress induces osteogenic differentiation of human mesenchymal stem cells

(2010) Gregory Yourek et al.   Regenerative Medicine

Endothelial Progenitor Cells and Mesenchymal Stem Cells Seeded onto β-TCP Granules Enhance Early Vascularization and Bone Healing in a Critical-Sized Bone Defect in Rats

(2010) Caroline Seebach et al.   TISSUE ENGINEERING PART A

Luciferase Labeling for Multipotent Stromal Cell Tracking in Spinal Fusion Versus Ectopic Bone Tissue Engineering in Mice and Rats

(2010) Ruth E. Geuze et al.   TISSUE ENGINEERING PART A

Synergistic Angiogenesis Promoting Effects of Extracellular Matrix Scaffolds and Adipose-Derived Stem Cells During Wound Repair

(2010) Shiyu Liu et al.   TISSUE ENGINEERING PART A

Bone Formation and Neovascularization Mediated by Mesenchymal Stem Cells and Endothelial Cells in Critical-Sized Calvarial Defects

(2010) Sebastian Koob et al.   TISSUE ENGINEERING PART A

Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

(2009) Jian-de Dong et al.   ACTA PHARMACOLOGICA SINICA

Controlled Growth Factor Delivery for Tissue Engineering

(2009) Prakriti Tayalia et al.   ADVANCED MATERIALS

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

(2009) Toshiyuki Kitaori et al.   ARTHRITIS AND RHEUMATISM

Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprolactone–starch scaffold and the in vitro development of vascularization

(2009) Marina I. Santos et al.   BIOMATERIALS

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration

(2009) Diederik H.R. Kempen et al.   BIOMATERIALS

Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects

(2009) Zhi-Yong Zhang et al.   BIOMATERIALS

Covalently-Immobilized Vascular Endothelial Growth Factor Promotes Endothelial Cell Tubulogenesis in Poly(ethylene glycol) Diacrylate Hydrogels

(2009) Julia E. Leslie-Barbick et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations

(2009) Ke Bai et al.   JOURNAL OF BIOMECHANICS

Local controlled release of VEGF and PDGF from a combined brushite–chitosan system enhances bone regeneration

(2009) Beatriz De la Riva et al.   JOURNAL OF CONTROLLED RELEASE

Vascularization in Bone Tissue Engineering: Physiology, Current Strategies, Major Hurdles and Future Challenges

(2009) Marina I. Santos et al.   MACROMOLECULAR BIOSCIENCE

Complications associated with single-level transforaminal lumbar interbody fusion

(2009) Jeffrey A. Rihn et al.   Spine Journal

Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model

(2009) Simon Young et al.   TISSUE ENGINEERING PART A

Rapid Anastomosis of Endothelial Progenitor Cell–Derived Vessels with Host Vasculature Is Promoted by a High Density of Cotransplanted Fibroblasts

(2009) Xiaofang Chen et al.   TISSUE ENGINEERING PART A

Mesenchymal stem cells for clinical application

(2009) L. Sensebé et al.   VOX SANGUINIS

Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells

(2008) Yi Hao Shen et al.   Acta Biomaterialia

The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins

(2008) Inbar Freeman et al.   BIOMATERIALS

Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering

(2008) Lauren S. Sefcik et al.   BIOMATERIALS

Oxygen generating scaffolds for enhancing engineered tissue survival

(2008) Se Heang Oh et al.   BIOMATERIALS

Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model

(2008) Zarana S. Patel et al.   BONE

Normal Bone Anatomy and Physiology

(2008) B. Clarke   Clinical Journal of the American Society of Nephrology

Composite implantation of mesenchymal stem cells with endothelial progenitor cells enhances tissue-engineered bone formation

(2008) Kazutada Usami et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Positive Regulation of Adult Bone Formation by Osteoblast-Specific Transcription Factor Osterix

(2008) Wook-Young Baek et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Promotion of osteogenesis in tissue‐engineered bone by pre‐seeding endothelial progenitor cells‐derived endothelial cells

(2008) Haiying Yu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effect of cell-based VEGF gene therapy on healing of a segmental bone defect

(2008) Ru Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Role of Vascular Endothelial Growth Factor in Wound Healing

(2008) Philip Bao et al.   JOURNAL OF SURGICAL RESEARCH

A Comprehensive Analysis of the Dual Roles of BMPs in Regulating Adipogenic and Osteogenic Differentiation of Mesenchymal Progenitor Cells

(2008) Quan Kang et al.   STEM CELLS AND DEVELOPMENT

Prevascularization of a Fibrin-Based Tissue Construct Accelerates the Formation of Functional Anastomosis with Host Vasculature

(2008) Xiaofang Chen et al.   TISSUE ENGINEERING PART A

Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells

(2007) Irene R. Dégano et al.   BIOMATERIALS

Endochondral ossification: How cartilage is converted into bone in the developing skeleton

(2007) E.J. Mackie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY