The Unfolded Protein Response and Diabetic Retinopathy

Recent developments in the treatment of age-related macular degeneration

(2014) Frank G. Holz et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization

(2013) Li Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Unfolded Protein Response Dysregulation in Oxidative Injury of Retinal Pigment Epithelial Cells

(2013) Chen Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

(2013) Lingfang Zeng et al.   CIRCULATION

Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy?

(2013) M. Du et al.   DIABETOLOGIA

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Mild Endoplasmic Reticulum Stress Promotes Retinal Neovascularization via Induction of BiP/GRP78

(2013) Shinsuke Nakamura et al.   PLoS One

Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells

(2013) Hidetaka Miyagi et al.   PLoS One

Suppression of XBP1S Mediates High Glucose-Induced Oxidative Stress and Extracellular Matrix Synthesis in Renal Mesangial Cell and Kidney of Diabetic Rats

(2013) Decui Shao et al.   PLoS One

ER stress inhibits neuronal death by promoting autophagy

(2012) Antoine Fouillet et al.   Autophagy

SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation

(2012) Zhou Jiang et al.   CELL CYCLE

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Muller Cell-Derived Inflammatory Cytokine Production in Diabetes

(2012) Y. Zhong et al.   DIABETES

Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes

(2012) C. Sims-Robinson et al.   DIABETOLOGIA

Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy

(2012) D. Fu et al.   DIABETOLOGIA

Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes

(2012) Y. Chen et al.   DIABETOLOGIA

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

(2012) Diego A Rodriguez et al.   EMBO JOURNAL

Mild Endoplasmic Reticulum Stress Augments the Proinflammatory Effect of IL-1β in Pancreatic Rat β-Cells via the IRE1α/XBP1s Pathway

(2012) Michela Miani et al.   ENDOCRINOLOGY

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Toll-Like Receptor 2 Ligand Pretreatment Attenuates Retinal Microglial Inflammatory Response but Enhances Phagocytic Activity toward Staphylococcus aureus

(2012) Travis Kochan et al.   INFECTION AND IMMUNITY

SLC33A1/AT-1 Protein Regulates the Induction of Autophagy Downstream of IRE1/XBP1 Pathway

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERdj4 Protein Is a Soluble Endoplasmic Reticulum (ER) DnaJ Family Protein That Interacts with ER-associated Degradation Machinery

(2012) Chunwei Walter Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death

(2012) John A. Vekich et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells

(2012) Yang Hu et al.   NEURON

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Retinal Muller Glia Initiate Innate Response to Infectious Stimuli via Toll-Like Receptor Signaling

(2012) Ashok Kumar et al.   PLoS One

X-Box Binding Protein 1 Is Essential for the Anti-Oxidant Defense and Cell Survival in the Retinal Pigment Epithelium

(2012) Yimin Zhong et al.   PLoS One

IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030

(2011) David R. Whiting et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis

(2011) Stephen J. Pandol et al.   DIGESTIVE DISEASES

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes

(2011) Ling Tang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death

(2011) Guangjun Jing et al.   Experimental Diabetes Research

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions

(2011) Soledad Miranda et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TLR2 Mediates the Innate Response of Retinal Muller Glia to Staphylococcus aureus

(2011) N. Shamsuddin et al.   JOURNAL OF IMMUNOLOGY

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Effect of neurotrophin-4 on endoplasmic reticulum stress-related neuronal apoptosis in diabetic and high glucose exposed rat retinas

(2011) Toshiyuki Oshitari et al.   NEUROSCIENCE LETTERS

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Autophagy - hot topic in AMD

(2010) Kai Kaarniranta   ACTA OPHTHALMOLOGICA

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

(2010) F. Allagnat et al.   DIABETOLOGIA

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An essential role for XBP-1 in host protection against immune activation in C. elegans

(2010) Claire E. Richardson et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

Regulation of extracellular-superoxide dismutase in rat retina pericytes

(2010) Tetsuo Adachi et al.   REDOX REPORT

The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy

(2009) Bin Li et al.   ACTA DIABETOLOGICA

Modern-Day Clinical Course of Type 1 Diabetes Mellitus After 30 Years' Duration

(2009)   ARCHIVES OF INTERNAL MEDICINE

The role of autophagy in pancreatic β-cell and diabetes

(2009) Yoshio Fujitani et al.   Autophagy

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

(2009) Soledad Matus et al.   Autophagy

Autophagy, exosomes and drusen formation in age-related macular degeneration

(2009) Ai Ling Wang et al.   Autophagy

Retinal ganglion cell death induced by endoplasmic reticulum stress in a chronic glaucoma model

(2009) Sang Hee Doh et al.   BRAIN RESEARCH

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

ER stress protects from retinal degeneration

(2009) César S Mendes et al.   EMBO JOURNAL

Expression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication

(2009) H Liu et al.   EYE

Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy

(2009) Jingming Li et al.   FEBS LETTERS

Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases

(2009) Takeru Yoshimura et al.   PLoS One

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Human HRD1 Promoter Carries a Functional Unfolded Protein Response Element to Which XBP1 but not ATF6 Directly Binds

(2008) K. Yamamoto et al.   JOURNAL OF BIOCHEMISTRY

Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration

(2008) Zhenglin Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of retinal blood flow in health and disease

(2008) Constantin J. Pournaras et al.   PROGRESS IN RETINAL AND EYE RESEARCH