Article
Endocrinology & Metabolism
Peter S. Linsley, Carla J. Greenbaum, Gerald T. Nepom
Summary: The goal of personalized medicine is to match the right drugs to the right patients at the right time. However, for complex diseases like type 1 diabetes, personalized therapy should consider factors such as treatment timing, patient stratification, pharmacodynamic biomarkers, and efficacy biomarkers. Research in personalized medicine for type 1 diabetes is providing insights for achieving personalized therapies for other complex diseases.
Article
Medical Laboratory Technology
Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Luis F. Lopez-Almodovar, Jorge Solis, Luis R. Padial, Teresa Tejerina, Montserrat Carrascal, Laura Mourino-Alvarez, Maria G. Barderas
Summary: Diabetes mellitus (DM) increases the risk of severe calcific aortic stenosis (CAS), but the relationship between these two diseases and the impact of DM on CAS progression is unclear. In this study, we analyzed calcified and noncalcified valve tissue from patients with severe CAS, with or without DM, using a proteomic strategy. We found that DM induces changes in the proteome of aortic valves, affecting valve calcification. This finding provides valuable insights into the pathogenesis of CAS and the personalized treatment of patients with both DM and CAS.
TRANSLATIONAL RESEARCH
(2023)
Review
Immunology
Reto Guler, Mumin Ozturk, Solima Sabeel, Bongani Motaung, Suraj P. Parihar, Friedrich Thienemann, Frank Brombacher
Summary: Tuberculosis remains a serious global health challenge, with the study of host immune responses crucial for finding new treatment methods. Granulomas, a pathological feature of tuberculosis, have a complex host response that can be modulated by Mycobacterium tuberculosis, promoting its survival within the host. Understanding these mechanisms is essential for the development of therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Pai-Yi Chiu, Fu-Chi Yang, Ming-Jang Chiu, Wei-Che Lin, Cheng-Hsien Lu, Shieh-Yueh Yang
Summary: This study investigated the combination of different biomarkers in AD, PD, and FTD and found that plasma biomarkers were consistent with pathology. This provides promise for the precise assessment of AD, PD, and FTD in clinical practice.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Gabriella Ferretti, Sara Serafini, Antonella Angiolillo, Paola Monterosso, Alfonso Di Costanzo, Carmela Matrone
Summary: Recently, measurable peripheral biomarkers in the plasma of patients with Alzheimer's disease have gained clinical interest. This study analyzes the changes in plasma levels of Aβ42, TNFα, and metabolites in AD patients and compares them with healthy elderly subjects. The study highlights the potential of combining different plasma signatures for patient stratification and personalized approaches in AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Analytical
Jiajia Cui, Zhipei Huang, Jiankang Wu
Summary: The cyclic alternating pattern is a periodic electroencephalogram activity that occurs during sleep and is correlated with sleep-related pathologies. In this study, the feasibility of using cardiopulmonary features to automatically detect the cyclic alternating pattern and diagnose sleep-related pathologies is explored. By analyzing and comparing the cardiopulmonary characteristics of different groups, an automatic recognition scheme is proposed. The scheme combines statistical models and machine learning algorithms to achieve high recognition rates for sleep-wake classification and disease diagnosis.
Article
Multidisciplinary Sciences
Magdalena Wisniewska, Michal Wisniewski, Marzena A. Lewandowska
Summary: Predictive biomarkers are crucial in determining treatment for cancer patients and in developing personalized targeted therapies.
PHYSICAL SCIENCES REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Arati Shastri, Dipali Sawant, Neel Parmar
Summary: Healthcare and pharmaceutical research have been advancing rapidly, but genetic mutations present a challenge in diagnosis and treatment. Personalized therapy has emerged to tailor medical treatment based on individual characteristics for better efficacy in patient care.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Article
Ophthalmology
Eyupcan Sensoy, Mehmet Citirik
Summary: This study tested the knowledge levels of ChatGPT, Bing, and Bard AI chatbots in ophthalmic pathology and intraocular tumors. The results show no significant difference in the accuracy of their answers.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Review
Oncology
Mahrou Vahabi, Giovanni Blandino, Silvia Di Agostino
Summary: Head and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous cancers with frequent alterations in multiple genes, including the role of microRNAs (miRNAs) in tumorigenesis and their potential as biomarkers and therapeutic targets for personalized treatment.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Pathology
K. Dufraing, F. Fenizia, E. Torlakovic, N. Wolstenholme, Z. C. Deans, E. Rouleau, M. Vyberg, S. Parry, E. Schuuring, Elisabeth M. C. Dequeker
Summary: Predictive biomarker testing is essential in personalized medicine for cancer patients, and laboratories participating in external quality assurance programs are crucial for ensuring accurate results. Recently, various EQA providers have collaborated to harmonize these programs further, emphasizing quality, transparency, and evidence-based approaches. This updated version aims to provide an overview of current practices and recommendations for predictive biomarker testing programs.
Review
Medicine, General & Internal
Tania S. Quiroz, Facundo Las Heras
Summary: Personalized medicine uses biomarkers to identify and classify patients, providing a new approach to the prevention, diagnosis, and treatment of each patient. Pathology has also adopted this personalized medicine strategy, identifying genetic markers in tumors through molecular studies and integrating histological and molecular information to treat these diseases in a safer and more effective way.
REVISTA MEDICA CLINICA LAS CONDES
(2022)
Article
Oncology
Anna Maria Berghella, Anna Aureli, Angelica Canossi, Tiziana Del Beato, Alessia Colanardi, Patrizia Pellegrini
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2019)
Article
Neurosciences
Laura Brandolini, Marta Grannonico, Gianluca Bianchini, Alessia Colanardi, Pierluigi Sebastiani, Antonella Paladini, Alba Piroli, Marcello Allegretti, Giustino Varrassi, Silvia Di Loreto
NEUROTOXICITY RESEARCH
(2019)
Correction
Neurosciences
Laura Brandolini, Marta Grannonico, Gianluca Bianchini, Alessia Colanardi, Pierluigi Sebastiani, Antonella Paladini, Alba Piroli, Marcello Allegretti, Giustino Varrassi, Silvia Di Loreto
NEUROTOXICITY RESEARCH
(2019)
Article
Immunology
Anna Aureli, Sara Aboulaghras, Khadija Oumhani, Tiziana Del Beato, Pierluigi Sebastiani, Alessia Colanardi, Rajae El Aouad, Imane Ben El Barhdadi, Daniela Piancatelli
Article
Immunology
Daniela Piancatelli, Daniela Maccarone, Alessia Colanardi, Pierluigi Sebastiani, Fabrizio D'Anselmi, Samuele Iesari, Barbara Binda, Francesco Pisani
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Urology & Nephrology
Daniela Piancatelli, Daniela Maccarone, Alessia Colanardi, Pierluigi Sebastiani, Katia Clemente, Samuele Iesari, Quirino Lai, Francesco Pisani
Article
Neurosciences
Marta Grannonico, Laura Brandolini, Giustino Varrassi, Pierluigi Sebastiani, Alessia Colanardi, Antonella Paladini, Alba Piroli, Marcello Allegretti, Silvia Di Loreto
Article
Immunology
Angelica Canossi, Khadija Oumhani, Tiziana Del Beato, Pierluigi Sebastiani, Alessia Colanardi, Anna Aureli
Summary: Spondyloarthropathies (SpA) are chronic inflammatory disorders that primarily affect the axial spine and asymmetrical peripheral joints. Genetic factors, including HLA-B27, play an important role in the pathogenesis of SpA. This study found that CD1E*01/01 genotype was associated with increased risk of SpA, while CD1E*01/02 genotype was associated with decreased risk. These findings suggest a potential genetic overlap between SpA and celiac disease, and provide insights for future therapeutic strategies.
Article
Biochemistry & Molecular Biology
Daniela Piancatelli, Anna Aureli, Pierluigi Sebastiani, Alessia Colanardi, Tiziana Del Beato, Lorenza Del Cane, Patrizia Sucapane, Carmine Marini, Silvia Di Loreto
Summary: This study found that serum levels of BDNF are reduced in patients with Alzheimer's disease, especially in females. Polymorphisms of the IL-1 alpha and BDNF genes appear to play a role in changes in serum BDNF, particularly in female patients, while no effects of other gene variants affecting oxidative stress have been found.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Cell Biology
Daniela Piancatelli, Sara Aboulaghras, Imane Ben El Barhdadi, Pierluigi Sebastiani, Tiziana Del Beato, Alessia Colanardi, Khadija Oumhani
Meeting Abstract
Cell Biology
Daniela Piancatelli, Daniela Maccarone, Fabrizio D'Anselmi, Pierluigi Sebastiani, Alessia Colanardi, Tiziana Del Beato, Ylenia Della Rocca, Barbara Binda, Alessandra Panarese, Davide Chiappori, Francesco Pisani
Meeting Abstract
Cell Biology
Anna Aureli, Khadija Oumhani, Imane Ben El Barhdadi, Tiziana Del Beato, Alessia Colanardi, Pierluigi Sebas-Tiani, Rajae El Aouad, Sara Aboulghras, Daniela Piancatelli
Meeting Abstract
Cell Biology
Angelica Canossi, Anna Aureli, Tiziana Del Beato, Giorgio Novelli, Oreste Buonomo, Giuseppe Sconocchia