Synthetic biology: advancing biological frontiers by building synthetic systems

Tunable Signal Processing in Synthetic MAP Kinase Cascades

(2011) Ellen C. O'Shaughnessy et al.   CELL

Pluripotency Factors in Embryonic Stem Cells Regulate Differentiation into Germ Layers

(2011) Matt Thomson et al.   CELL

Synthetic circuit identifies subpopulations with sustained memory of DNA damage

(2011) D. R. Burrill et al.   GENES & DEVELOPMENT

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler

(2011) Zengyi Shao et al.   Molecular BioSystems

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

(2011) Jessica S. Dymond et al.   NATURE

Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity

(2011) Andrew H. Babiskin et al.   NUCLEIC ACIDS RESEARCH

Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway

(2011) Mauricio S. Antunes et al.   PLoS One

Self-Organization, Layered Structure, and Aggregation Enhance Persistence of a Synthetic Biofilm Consortium

(2011) Katie Brenner et al.   PLoS One

Synthetic Biology: Integrated Gene Circuits

(2011) N. Nandagopal et al.   SCIENCE

Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

(2011) C. J. Delebecque et al.   SCIENCE

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

(2011) Farren J. Isaacs et al.   SCIENCE

Regulatory gene network circuits underlying T cell development from multipotent progenitors

(2011) Hao Yuan Kueh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

(2010) Christian Kemmer et al.   JOURNAL OF CONTROLLED RELEASE

Remission of Diabetes by Insulin Gene Therapy Using a Hepatocyte-specific and Glucose-responsive Synthetic Promoter

(2010) Jaeseok Han et al.   MOLECULAR THERAPY

Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’

(2010) Alvin Tamsir et al.   NATURE

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

A synchronized quorum of genetic clocks

(2010) Tal Danino et al.   NATURE

Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides

(2010) Joseph R Warner et al.   NATURE BIOTECHNOLOGY

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

(2010) Christian Kemmer et al.   NATURE BIOTECHNOLOGY

Reprogramming bacteria to seek and destroy an herbicide

(2010) Joy Sinha et al.   Nature Chemical Biology

Chemical synthesis of the mouse mitochondrial genome

(2010) Daniel G Gibson et al.   NATURE METHODS

Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process

(2010) Emily M. LeProust et al.   NUCLEIC ACIDS RESEARCH

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

(2010) Y. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking, tuning, and terminating microbial physiology using synthetic riboregulators

(2010) J. M. Callura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

(2010) S. J. Culler et al.   SCIENCE

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits

(2009) Tolga Çağatay et al.   CELL

A Synthetic Genetic Edge Detection Program

(2009) Jeffrey J. Tabor et al.   CELL

Frameworks for Programming Biological Function through RNA Parts and Devices

(2009) Maung Nyan Win et al.   CHEMISTRY & BIOLOGY

Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae

(2009) Michael Naesby et al.   Microbial Cell Factories

Metals, minerals and microbes: geomicrobiology and bioremediation

(2009) G. M. Gadd   MICROBIOLOGY-SGM

A synthetic metabolite-based mammalian inter-cell signaling system

(2009) Wilfried Weber et al.   Molecular BioSystems

A tunable synthetic mammalian oscillator

(2009) Marcel Tigges et al.   NATURE

Programming cells by multiplex genome engineering and accelerated evolution

(2009) Harris H. Wang et al.   NATURE

Diversity-based, model-guided construction of synthetic gene networks with predicted functions

(2009) Tom Ellis et al.   NATURE BIOTECHNOLOGY

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Modularity of MAP kinases allows deformation of their signalling pathways

(2009) Areez Mody et al.   NATURE CELL BIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

(2009) M. Gitzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Gene Networks That Count

(2009) A. E. Friedland et al.   SCIENCE

A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells

(2008) Nimet Maherali et al.   Cell Stem Cell

Split-Ubiquitin and the Split-Protein Sensors: Chessman for the Endgame

(2008) Judith Müller et al.   CHEMBIOCHEM

A fast, robust and tunable synthetic gene oscillator

(2008) Jesse Stricker et al.   NATURE

Refinement and standardization of synthetic biological parts and devices

(2008) Barry Canton et al.   NATURE BIOTECHNOLOGY

DDBJ dealing with mass data produced by the second generation sequencer

(2008) H. Sugawara et al.   NUCLEIC ACIDS RESEARCH

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

(2008) D. G. Gibson et al.   SCIENCE

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

(2008) C. J. Bashor et al.   SCIENCE

Higher-Order Cellular Information Processing with Synthetic RNA Devices

(2008) M. N. Win et al.   SCIENCE