Article
Agriculture, Dairy & Animal Science
A. J. Cowieson, Heng-Xiao Zhai
Summary: The study found that myo-inositol has an energy equivalence of approximately 78% of dextrose for young broiler chicks, but exerts a range of extra effects on BW gain, FCR, etc. The displacement of dextrose with myo-inositol significantly reduces FCR, with no effect on bone mineral concentration; myo-inositol supplementation decreases ileal digestibility of DM, calcium, and energy but increases total tract retention of CP.
Article
Oncology
Ivo Grgic, Fabienne Tschanz, Nathalie Borgeaud, Anurag Gupta, Pierre-Alain Clavien, Matthias Guckenberger, Rolf Graf, Martin Pruschy
Summary: ITPP induces tumor oxygenation and enhances DNA damage, promoting radiosensitization and reducing tumor growth when combined with ionizing radiation. The combined treatment modality also protects tumor vasculature, prevents tumor hypoxia, and increases immune cell infiltration, ultimately enhancing the efficacy of radiation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biotechnology & Applied Microbiology
Nan Lu, Chenglin Zhang, Wenjie Zhang, Haoran Xu, Yuhong Li, Minhua Wei, Jing Meng, Yan Meng, Junzhe Wang, Ning Chen
Summary: In this study, a myo-inositol-inducible expression vector pMI-4 was constructed for stable replication in Corynebacterium glutamicum. The vector showed potential applications in metabolic engineering and industrial fermentation by significantly accumulating 5-aminolevulinic acid through overexpression of hemA(M) and hemL.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu-Hong Xie, Ling Wang, Ming-Liang Li, Zhi-Cheng Gong, Jie Du
Summary: Exogenous myo-inositol can reduce excessive apoptosis in cisplatin-induced acute kidney injury (AKI), indicating its protective role in AKI.
Review
Biochemistry & Molecular Biology
Anshu Alok, Sadhana Singh, Pankaj Kumar, Kaushal K. Bhati
Summary: Myo-inositol is a widely present organic compound that serves as a substrate in various biosynthesis pathways. The myo-inositol pathway and enzymes have potential implications in plant physiology and crop improvement. Recent studies have shown the crosstalk between the myo-inositol pathway and other important biosynthesis and stress responsive pathways in plants. The exploration of myo-inositol derivatives and associated pathways could open up new directions for understanding stress-responsive metabolic networks.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Antonowski, Adam Osowski, Damian Szczesny, Joanna Szablinska-Piernik, Jerzy Juskiewicz, Leslaw Lahuta, Andrzej Rynkiewicz, Joanna Wojtkiewicz
Summary: This study investigated the concentration change of myo-inositol solution in the serum of Wistar rats after oral administration. The results showed that the myo-inositol concentration reached its peak in the first hour and then rapidly declined. However, even after 24 hours, the concentration remained higher than before administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Haonan Cao, Tianyun Guo, Xuemei Deng, Xing Huo, Shouchu Tang, Jian Liu, Xiaolei Wang
Summary: Selective photoredox reactions allow direct alkylation of unprotected myo-inositol at C4, offering a possibility for selective C-H alkylations without the need for multi-step protection-deprotection strategies.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Riccardo Gambioli, Gianpiero Forte, Giovanni Buzzaccarini, Vittorio Unfer, Antonio Simone Lagana
Summary: Pregnancy is a complex process, and myo-inositol may have positive effects on fertility and preventing pregnancy-related pathologies, with potential therapeutic benefits.
Review
Nutrition & Dietetics
Mariano Bizzarri, Noemi Monti, Aurora Piombarolo, Antonio Angeloni, Roberto Verna
Summary: Myo-inositol is the most abundant natural polyol among the nine structural isomers. It plays a crucial role in biochemical processes governing cellular transitions and insulin transduction. It also affects glucose metabolism and steroid hormone synthesis, and has been successfully used in the management of polycystic ovarian syndrome.
Article
Fisheries
Xianyong Bu, Jiahua Zhu, Shubin Liu, Chunling Wang, Shusheng Xiao, Maixin Lu, Erchao Li, Xiaodan Wang, Jian G. Qin, Liqiao Chen
Summary: The study showed that dietary myo-inositol at 400 mg/kg significantly improved the weight gain and growth rate of Oreochromis mossambicus under long-term salinity stress, reduced serum glucose and insulin levels, and increased cortisol, sodium, and chloride ion levels. Myo-inositol can also regulate lipid and pyruvic acid metabolism, increase phospholipid synthesis-related mRNA levels, and improve antioxidant properties in fish facing salinity stress.
Article
Plant Sciences
Yapeng Fan, Fanjia Peng, Ruifeng Cui, Shuai Wang, Yupeng Cui, Xuke Lu, Hui Huang, Kesong Ni, Xiaoyu Liu, Tiantian Jiang, Xixian Feng, Mengyue Liu, Yuqian Lei, Wenhua Chen, Yuan Meng, Mingge Han, Delong Wang, Zujun Yin, Xiugui Chen, Junjuan Wang, Yujun Li, Lixue Guo, Lanjie Zhao, Wuwei Ye
Summary: This study provides a comprehensive analysis on the expression profile and functions of the IMP gene family under abiotic stress in cotton. GhIMP10D gene showed the highest expression level under alkaline stress and may regulate tolerance to alkaline stress by regulating the activity of antioxidant enzymes and the content of AsA. This study contributes to the broader discussion of the structure and alkaline resistance of IMP genes in cotton.
Article
Chemistry, Analytical
Murugesan Karthikeyan, Marimuthu Dhinesh Kumar, Ganesan Kaniraja, Periyasamy Ananthappan, Vairathevar Sivasamy Vasantha, Chandran Karunakaran
Summary: Two molecular imprinting polymer (MIP) sensor matrixes were developed for detecting myo-inositol (MI), one using 3-aminophenylboronic acid (3-APBA) electropolymerization and the other utilizing gold nanoparticles (AuNPs) initially electrodeposited on a screen-printed carbon electrode (SPCE). Surface modification with AuNPs enhanced the electrochemical signal. The performance of the MI/PAPBA/AuNPs/SPCE imprinted sensor was better than the MI/PAPBA/SPCE sensor. It was successfully validated for the detection of myo-inositol in human plasma samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Plant Sciences
Shivani Kathi, Haydee Laza, Sukhbir Singh, Leslie Thompson, Wei Li, Catherine Simpson
Summary: The consumption of plants is important for human health as they provide essential nutrients and phytonutrients that play a role in disease prevention. However, modern diets with increased consumption of processed foods result in insufficient intake of nutrients like vitamin C. While supplements can address some nutrient deficiencies, they are not as diverse or bioavailable as nutrients in plants. Increasing nutrient abundance in plants can reduce the need for supplements. In this study, broccoli microgreens were grown with supplemental ascorbic acid to increase vitamin C content, without negatively impacting plant health and mineral composition.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Andrew F. Paquettea, Beatrice E. Carbone, Seth Vogel, Erica Israel, Sarah D. Maria, Nikita P. Patil, Saroj Sah, Dhrubajyoti Chowdhury, Ilona Kondratiuk, Beau Labhart, Ardythe L. Morrow, Shay C. Phillips, Chenzhong Kuang, Dirk Hondmann, Neeraj Pandey, Thomas Biederer
Summary: By analyzing human milk samples from different populations, we found that the carbocyclic sugar myo-inositol promotes brain development. Myo-inositol is most abundant during early lactation when neuronal connections rapidly form in infants. It enhances synapse abundance in human excitatory neurons and cultured rat neurons in a dose-dependent manner by improving their ability to respond to transsynaptic interactions. In mice, dietary supplementation of myo-inositol increases the size of excitatory postsynaptic sites in the developing cortex. Moreover, myo-inositol is bioactive in mature brain tissue, as it increases the number and size of postsynaptic specializations and excitatory synapse density in organotypic slices. This study advances our understanding of the role of human milk in infant brain development and identifies myo-inositol as a component that promotes the formation of neuronal connections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Analytical
Cristina Tortolini, Valeria Gigli, Flavio Rizzo, Andrea Lenzi, Mariano Bizzarri, Antonio Angeloni, Riccarda Antiochia
Summary: This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol and D-chiro-inositol by means of bovine serum albumin adsorption onto a multi-walled carbon nanotube graphite screen-printed electrode.
Article
Biochemistry & Molecular Biology
Janet L. Donahue, Shannon R. Alford, Javad Torabinejad, Rachel E. Kerwin, Aida Nourbakhsh, W. Keith Ray, Marcy Hernick, Xinyi Huang, Blair M. Lyons, Pyae P. Hein, Glenda E. Gillaspy
Article
Soil Science
Hailin Zhang, Joao Antonangelo, John Grove, Deanna Osmond, Nathan A. Slaton, Shannon Alford, Robert Florence, Gobena Huluka, David Herring Hardy, Jason Lessl, Rory Maguire, Rao Mylavarapu, J. Larry Oldham, Eugenia M. Pena-Yewtukhiw, Tony Provin, Leticia Sonon, David Sotomayor, Jim Wang
Summary: Thirteen states agreed to share their soil test based P and K rate recommendations for nine major crops, with the aim of comparing fertilizer recommendations, rationalizing similar recommendations across state lines, and examining challenges to developing a cooperative regional approach to P and K recommendations. Differences in fertilizer recommendation philosophies among states were found to be the main reason behind discrepancies, leading to important recommendation differences due to different philosophies, numerical presentations, and extraction procedures. Despite widespread adoption of the Mehlich-3 extraction procedure, variation in fertilizer P and K rate recommendations among states has not been reduced, highlighting the need to examine and standardize the soil testing and recommendation process.
SOIL SCIENCE SOCIETY OF AMERICA JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
EJ Wojcik, NA Dalrymple, SR Alford, RA Walker, SY Kim