Article
Gastroenterology & Hepatology
Hannah Zogg, Rajan Singh, Se Eun Ha, Zhuqing Wang, Byungchang Jin, Mariah Ha, Mirabel Dafinone, Tylar Batalon, Nicholas Hoberg, Sandra Poudrier, Linda Nguyen, Wei Yan, Brian T. Layden, Lara R. Dugas, Kenton M. Sanders, Seungil Ro
Summary: This study investigates the role of miR-10b-5p in regulating gut barrier function and its link to diabetes and gut dysmotility.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Immunology
Isidora Panez-Toro, Dominique Heymann, Francois Gouin, Jerome Amiaud, Marie-Francoise Heymann, Luis A. Cordova
Summary: This review discusses the role of non-myelomonocytic cells in periprosthetic tissues exposed to wear particles. T cells and B cells are found to coexist with multinucleated giant cells in periprosthetic membranes infiltrated by polyethylene and metallic particles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Amanda L. Phelps, Francisco J. Salguero, Laura Hunter, Alexander L. Stoll, Dominic C. Jenner, Lyn M. O'Brien, E. Diane Williamson, M. Stephen Lever, Thomas R. Laws
Summary: Venezuelan equine encephalitis virus (VEEV) causes a disease characterized by systemic infection and sometimes severe encephalitis in humans. In a mouse model, biomarkers related to inflammation were identified and found to be strongly correlated with disease severity. The virus was found in various regions of the brain, and the olfactory bulb and midbrain/thalamus showed the most pathology. Targeting these biomarkers may help improve the encephalitic syndrome caused by VEEV.
Article
Biochemistry & Molecular Biology
Jillian Bonaroti, Sultan Abdelhamid, Upendra Kar, Jason Sperry, Ruben Zamora, Rami Ahmd Namas, Todd McKinley, Yoram Vodovotz, Timothy Billiar
Summary: The immune response following trauma plays a crucial role in clinical outcomes, with excessive or sustained inflammation potentially leading to organ damage. Studying the dynamic patterns of immune mediator responses in human trauma is essential for understanding the pathophysiology of traumatic injury.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Neurosciences
Petra Tavcar, Maja Potokar, Marko Kolenc, Misa Korva, Tatjana Avsic-Zupanc, Robert Zorec, Jernej Jorgacevski
Summary: The article discusses the neurological manifestations of COVID-19 and its relationship with astrocytes, emphasizing the impact of neurotropic mechanisms on the CNS. This provides key information for understanding the pathophysiology of COVID-19 and developing new strategies to mitigate its neurotropic manifestations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Clinical Neurology
Antonio Corsello, Lorenzo Scatigno, Annalisa Govoni, Gianvincenzo Zuccotti, Frederic Gottrand, Claudio Romano, Elvira Verduci
Summary: Intestinal motility disorders are common in children with neurological impairment, characterized by abnormal gut movements and symptoms such as constipation, diarrhea, reflux, and vomiting. Nutritional management plays an important role in improving their quality of life.
FRONTIERS IN NEUROLOGY
(2023)
Article
Virology
Guanxiang Liang, Ana Georgina Cobian-Guemes, Lindsey Albenberg, Frederic Bushman
Summary: Dysbiosis of the microbiome plays a significant role in inflammatory bowel diseases, and the study of viral communities in relation to these diseases is still relatively limited. Metagenomics has been used to investigate the virome, revealing common properties associated with IBD, but no single virus has been tightly linked to the disease.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hongying Huang, Tong Zhao, Jinchen Li, Jingyi Shen, Rong Xiao, Weiwei Ma
Summary: This study investigated the relationship between diabetes-associated cognitive dysfunction (DACD) and gut microbiota, dietary fatty acid intake levels, inflammatory cytokines, and miRs in patients with type 2 diabetes mellitus (T2DM). The results showed that the composition of gut microbiota was different between DACD and T2DM patients, and was positively correlated with interleukin-12 (IL-12) and miR-142-5p. This suggests that alterations in gut microbiota may impact cognition through the mediation of IL-12 and miR-142-5p in T2DM patients.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Christine Vazquez, Kellie A. Jurado
Summary: This review outlines the immune regulatory mechanisms in the central nervous system (CNS) and the strategies viruses use to bypass the blood-brain barrier. Future questions in this rapidly expanding field are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Suvarin Pavasutthipaisit, Melanie Stoff, Tim Ebbecke, Malgorzata Ciurkiewicz, Sabine Mayer-Lambertz, Theresa Stoerk, Kevin D. Pavelko, Bernd Lepenies, Andreas Beineke
Summary: Genetic ablation of CARD9 exacerbates inflammatory responses and neuronal damage following neurotropic virus infection, while having no effect on the initiation of antiviral immune responses or virus elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Yu-jia Zhao, Kai-fei Xu, Fu-xing Shu, Feng Zhang
Summary: Neurodegenerative diseases are a group of disorders characterized by the progressive deterioration of nervous system functionality. The precise etiological factors remain unclear, but aging, genetic predisposition, and environmental stressors may contribute. Viral infections, especially neurotropic viruses, are believed to play a role in the onset and progression of these diseases. The autophagy pathway mediated by viral infection can cause pathological aggregation of cellular proteins associated with various neurodegenerative diseases. Understanding the mechanisms underlying these diseases is critical for developing targeted therapeutic approaches.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Immunology
Mojgan Noroozi Karimabad, Gholamhossein Hassanshahi, Nicholas G. Kounis, Virginia Mplani, Pavlos Roditis, Christos Gogos, Maria Lagadinou, Stelios F. Assimakopoulos, Periklis Dousdampanis, Ioanna Koniari
Summary: COVID-19 is a progressive viral pandemic associated with immunological mechanisms. The CC and CXC chemokines play a role in COVID-19 and may reflect the development of reasonable strategies for COVID-19 management.
Review
Pharmacology & Pharmacy
Jian Lu, Wenlong Hou, Sunan Gao, Ye Zhang, Youming Zong
Summary: With the aging of the world population, more elderly patients are undergoing anesthesia and surgery, leading to increasing attention towards perioperative neurocognitive dysfunction (PND). PND includes preoperatively cognitive impairment, postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction, and the role of the gut microbiota-gut-brain axis in its pathogenesis remains unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Manasa Sagaram, Amor J. Royer, Huirong Hu, Abhas Rajhans, Ranganathan Parthasarathy, Sathya Sridevi Krishnasamy, Sri Prakash Mokshagundam, Maiying Kong, Melanie L. Schwandt, Dipendra Parajuli, Matthew C. Cave, Vatsalya Vatsalya
Summary: This study investigates the role of alcohol-induced gut dysfunction and pro-inflammatory cytokine profile in the thyroid function of patients with alcohol use disorder (AUD).
Article
Genetics & Heredity
Jinjian Li, Qing Meng, Xuehui Zhou, Hehe Zhao, Kun Wang, Huanjiang Niu, Yirong Wang
Summary: Glioma, the most common intracranial malignant tumor, is a significant health challenge due to its impact on brain function. The current treatments, including surgery, radiotherapy, and chemotherapy, have limited efficacy. Researchers have explored the use of oncolytic viruses (OVs) as a novel treatment approach. OVs work by activating the immune system and inducing tumor cell apoptosis. However, the classification of OVs is still unclear, and the clinical application faces challenges.
Article
Gastroenterology & Hepatology
Valentina Mari, Valentina Angerilli, Giada Munari, Marco Scarpa, Quoc Riccardo Bao, Salvatore Pucciarelli, Matteo Fassan, Gaya Spolverato
Summary: This review outlines the molecular pathways involved in peritoneal metastatic dissemination in gastric cancer, highlighting the lack of comprehensive understanding of the complex molecular landscape of this disease. The integration of molecular profiling and histological evaluation is recommended for risk prediction assessment of peritoneal dissemination.
DIGESTIVE DISEASES
(2023)
Article
Surgery
Ylenia Camilla Spolverato, Romeo Bardini, Mario Gruppo, Cesare Ruffolo, Imerio Angriman, Mario Plebani, Marco Scarpa
Summary: The study identified pre-operative biomarkers, including serum amylase, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and prognostic nutritional index (PNI), which can accurately predict occult advanced disease (OAD) in pancreatic cancer patients.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Gaya Spolverato, Matteo Fassan, Giulia Capelli, Melania Scarpa, Silvia Negro, Valentina Chiminazzo, Andromachi Kotsafti, Imerio Angriman, Michela Campi, Ottavia De Simoni, Cesare Ruffolo, Stepanyan Astghik, Chiara Vignotto, Federico Scognamiglio, Giulia Becherucci, Giorgio Rivella, Francesco Marchegiani, Luca Facci, Francesca Bergamo, Stefano Brignola, Gianluca Businello, Vincenza Guzzardo, Luca Dal Santo, Roberta Salmaso, Marco Massani, Anna Pozza, Ivana Cataldo, Tommaso Stecca, Angelo Paolo Dei Tos, Vittorina Zagonel, Pierluigi Pilati, Boris Franzato, Antonio Scapinello, Giovanni Pirozzolo, Alfonso Recordare, Roberto Merenda, Giovanni Bordignon, Silvio Guerriero, Chiara Romiti, Giuseppe Portale, Chiara Cipollari, Maurizio Zizzo, Andrea Porzionato, Marco Agostini, Francesco Cavallin, Barbara Di Camillo, Romeo Bardini, Isacco Maretto, Ignazio Castagliuolo, Salvatore Pucciarelli, Marco Scarpa
Summary: This study evaluated the sex differences in the immune microenvironment of rectal cancer patients and found that male patients had more frequent oncogene mutations associated with lower expression of T-cell activation genes, while female patients had more Th1 cells and cytotoxic T cells in the healthy mucosa, suggesting a potentially better immune response to the tumor.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Polymer Science
Alice Donato, Federico Fontana, Rina Venerando, Antonino Di Stefano, Paola Brun
Summary: The study aimed to evaluate the anti-inflammatory and antioxidant effects of lactose-modified hyaluronic acids on smoking-related diseases. The results showed that HYLACH with a lactosylation percentage of 10-40% were the best ligands, capable of attenuating macrophage-mediated inflammation, inhibiting MMP expression, and exhibiting antioxidative effects.
Article
Infectious Diseases
Giulia Bernabe, Mahmoud Elsayed Mosaad Shalata, Veronica Zatta, Massimo Bellato, Andrea Porzionato, Ignazio Castagliuolo, Paola Brun
Summary: The side effects of antibiotic treatment are directly related to intestinal dysbiosis. This study examined the long-term effects of antibiotic-induced dysbiosis on the enteric nervous system and the impact of spontaneous restoration of gut microbiota on gastrointestinal functions. Two weeks of antibiotic treatment significantly altered gut microbial composition, and some bacterial genera did not regain their abundance after six weeks of discontinuation.
Article
Engineering, Multidisciplinary
Annj Zamuner, Elena Zeni, Hamada Elsayed, Michele Di Foggia, Paola Taddei, Antonella Pasquato, Lucy Di Silvio, Enrico Bernardo, Paola Brun, Monica Dettin
Summary: Hardystonite-based bioceramic foams were easily obtained via thermal treatment of silicone resins and reactive oxide fillers in air. By incorporating strontium oxide and magnesium oxide precursors, a complex solid solution with superior biocompatibility and bioactivity properties can be obtained.
Letter
Allergy
Andrea Leonardi, Fabiano Cavarzeran, Umberto Rosani, Giuseppe Righetti, Jean-Sebastien Garrigue, Paola Brun
Article
Biochemistry & Molecular Biology
Andrea Carpi, Md Abdur Rahim, Angela Marin, Marco Armellin, Paola Brun, Giovanni Miotto, Renzo Dal Monte, Livio Trainotti
Summary: Plant cell cultures have emerged as a promising tool for producing active molecules, such as flavonols and anthocyanins, which have beneficial health properties. The synthesis of these molecules is finely regulated by specific transcription factors, and high expression levels can be achieved in tobacco cell lines. A single-column-based purification protocol was developed to produce a stable lyophile with antioxidant, anti-inflammatory, antibacterial, and wound-healing activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Silvestro Ennio D'Anna, Francesca Dossena, Isabella Gnemmi, Paola Brun, Antonio Spanevello, Vitina Carriero, Francesca Bertolini, Mauro Maniscalco, Fabio LM. Ricciardolo, Bruno Balbi, Antonino Di Stefano
Summary: This study aimed to determine the microbiota associated with markers of innate immune response in COPD patients with rapid lung functional decline. The results showed an increase of Pseudomonas aeruginosa and Streptococcus pneumoniae in rapid decliners, and S. pneumoniae also increased compared to non decliners. In summary, these findings may help in the prognostic stratification and treatment of patients.
RESPIRATORY MEDICINE
(2023)
Review
Oncology
Astghik Stepanyan, Matteo Fassan, Gaya Spolverato, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa, IMMUNOREACT Study Grp
Summary: Neoadjuvant therapy (NT) followed by surgery is the main treatment for rectal cancer patients. Immune biomarkers are being recognized as potential predictors of NT response. A meta-analysis was performed to estimate their predictive significance.
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Article
Oncology
Ottavia De Simoni, Luca Dal Santo, Marco Scarpa, Giada Munari, Ylenia Camilla Spolverato, Antonio Scapinello, Sara Lonardi, Caterina Solda, Francesca Bergamo, Alberto Fantin, Romeo Bardini, Pierluigi Pilati, Matteo Fassan, Mario Gruppo
Summary: The aim of this study is to determine the potential significant tumor microenvironment (TME) immune markers of long-term survival in pancreatic ductal adenocarcinoma (PDAC) patients. Immunohistochemical staining was performed to characterize the TME using tissue microarray. The results showed that high density of CD8+ lymphocytes and low density of FOXP3+ and iNOS+ tumor-associated macrophages (TAMs) are predictors of good prognosis in PDAC patients.
Article
Multidisciplinary Sciences
Massimo Bellato, Marco Cappellato, Francesca Longhin, Claudia Del Vecchio, Giuseppina Brancaccio, Anna Maria Cattelan, Paola Brun, Claudio Salaris, Ignazio Castagliuolo, Barbara Di Camillo
Summary: This study investigates the respiratory tract microbial communities of COVID-19 patients using 16S rDNA sequencing and aims to identify microbial signatures predictive of disease progression to intubation.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Gaya Spolverato, Matteo Fassan, Melania Scarpa, Astghik Stepanyan, Ottavia De Simoni, Federico Scognamiglio, Valentina Chiminazzo, Clarissa De Nardi, Giulia Tamponi, Silvia Negro, Imerio Angriman, Andromachi Kotsafti, Cesare Ruffolo, Chiara Vignotto, Maurizio Zizzo, Francesco Marchegiani, Luca Facci, Francesca Bergamo, Stefano Brignola, Gianluca Businello, Vincenza Guzzardo, Luca Dal Santo, Roberta Salmaso, Carlotta Ceccon, Marco Massani, Anna Pozza, Ivana Cataldo, Tommaso Stecca, Angelo Paolo Dei Tos, Vittorina Zagonel, Pierluigi Pilati, Boris Franzato, Antonio Scapinello, Giovanni Pirozzolo, Alfonso Recordare, Roberto Merenda, Giovanni Bordignon, Licia Laurino, Silvio Guerriero, Chiara Romiti, Giuseppe Portale, Chiara Cipollari, Salvatore Candioli, Laura Gavagna, Giulia Pozza, Mario Godina, Isabella Mondi, Giulia Noaro, Monica Ortenzi, Mario Guerrieri, Giovanni Tagliente, Monica Tomassi, Umberto Tedeschi, Andrea Porzionato, Marco Agostini, Isacco Maretto, Quoc Riccardo Bao, Francesco Cavallin, Barbara Di Camillo, Romeo Bardini, Ignazio Castagliuolo, Salvatore Pucciarelli, Marco Scarpa
Summary: The study found that early-onset rectal cancer is rarely associated with common hereditary syndromes. The tumor microenvironment is characterized by a high frequency of mutations impairing the local immune surveillance mechanisms and low expression of immune editing-related genes. A constitutively low number of CD4 T cells associated with a high number of T regulators indicates an imbalance in the immune surveillance mechanisms.
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Chiara Vignotto, Melania Scarpa, Astghik Stepanyan, Roberta Salmaso, Andromachi Kotsafti, Ottavia De Simoni, Giulia Becherucci, Silvia Negro, Gaya Spolverato, Federico Scognamiglio, Nicole Maddalena Maturi, Cesare Ruffolo, Imerio Angriman, Valentina Chiminazzo, Isacco Maretto, Maurizio Zizzo, Francesca Bergamo, Stefano Brignola, Gianluca Businello, Vincenza Guzzardo, Luca Dal Santo, Carlotta Ceccon, Marco Massani, Anna Pozza, Ivana Cataldo, Tommaso Stecca, Angelo Dei Tos, Vittorina Zagonel, Pierluigi Pilati, Boris Franzato, Antonio Scapinello, Beatrice Salmaso, Giovanni Pirozzolo, Alfonso Recordare, Licia Laurino, Andrea Porzionato, Marco Agostini, Quoc Riccardo Bao, Francesco Cavallin, Barbara Di Camillo, Romeo Bardini, Ignazio Castagliuolo, Salvatore Pucciarelli, Matteo Fassan, Marco Scarpa