Review
Multidisciplinary Sciences
Mengying Wang, Yuwei Wang, Mingshu Wang, Mafeng Liu, Anchun Cheng
Summary: Bacteria acquire and tolerate heme through various mechanisms to maintain heme homeostasis. This review focuses on the detailed mechanisms of heme acquisition and tolerance in Gram-positive model bacteria, such as Staphylococcus and Streptococcus. Understanding these mechanisms is not only important for a comprehensive understanding of heme homeostasis in Gram-positive bacteria but also for the development of antimicrobial agents.
Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Article
Microbiology
Monica R. Cesinger, Nicole H. Schwardt, Cortney R. Halsey, Maureen K. Thomason, Michelle L. Reniere
Summary: The study revealed that L. monocytogenes utilizes a diverse set of peroxidase enzymes to defend against peroxide toxicity during infection of mammalian cells, with fri being essential for cytosolic growth.
MICROBIOLOGY SPECTRUM
(2021)
Article
Chemistry, Multidisciplinary
Changjiang Fan, Xinyue Meng, Wei Yang, Peiyan Wang, Wenguang Chang, Peifeng Li, Jianxun Wang
Summary: A labeling chemistry-based method, APSC-8-oxoGua-seq, is developed for sequencing 8-oxoGua in the microRNA transcriptome. The method uses N-(3-azidopropyl)-spermine-5-carboxamide (APSC) for selective labeling of 8-oxoGua, allowing the conjugation of a cleavable linker via the click reaction for 8-oxoGua pull-down and sequencing. APSC-8-oxoGua-seq enables identification of 8-oxoGua at single-base resolution.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Article
Immunology
Bing Wu, Yanwei Wu, Chen Fan, Chunlan Feng, Haoyu Wang, Fang Bai, Jianping Zuo, Wei Tang
Summary: Heme plays an important role in the pathogenesis of systemic lupus erythematosus (SLE), and supplementation of heme can significantly improve lupus symptoms, reduce proteinuria levels, and alleviate organ enlargement.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yumeng Quan, Yu Du, Changrui Wu, Sumin Gu, Jean X. Jiang
Summary: Our study reveals that Cx43 hemichannels (HCs) in lens epithelial cells play a crucial role in protecting the lens against oxidative stress by facilitating the exchange of oxidants and antioxidants, thereby maintaining redox homeostasis. Activation of Cx43 HCs by oxidative stress results in a reduction of intracellular reactive oxygen species (ROS) accumulation and regulation of anti-oxidative gene expression, contributing to preventing cataract formation during aging.
Review
Biochemistry & Molecular Biology
Asli Devrim-Lanpir, Lee Hill, Beat Knechtle
Summary: Studies have shown that N-acetylcysteine (NAC) may play a positive role in improving athletes' adaptability to oxidative stress, but its supplementation remains controversial and requires further research for clarification.
Review
Biochemistry & Molecular Biology
Meytal Radzinski, Tal Oppenheim, Norman Metanis, Dana Reichmann
Summary: Protein homeostasis and redox regulation are closely connected, with redox-regulated proteins or thiol-based switches at the core. Research discusses the redox code of the proteostasis network and evolving strategies of antioxidant proteins under oxidative stress conditions. The importance of cysteine in protein degradation is also highlighted.
Article
Environmental Sciences
Julin Yuan, Yao Zheng, Zhimin Gu
Summary: The study compared the effects of cypermethrin on the hepatic expression profiles in red claw crayfish using transcriptomic and proteomic approaches, revealing that cypermethrin can induce antioxidant and biotransformation modulation variations to resist immunotoxicity and oxidative damages.
Article
Engineering, Biomedical
Qianqian Zhang, Zhen Sun, Wenbo Sun, Bin Yu, Jianhua Liu, Chunhuan Jiang, Lehui Lu
Summary: This study proposes a synergetic antioxidant inhibition strategy to reduce the intracellular antioxidant capacity for hypoxic tumor therapy. The developed nanoplatform can induce apoptosis and ferroptosis in tumor cells, showing great potential for practical applications.
ACTA BIOMATERIALIA
(2023)
Article
Plant Sciences
Patrick J. Horn
Summary: Plants produce diverse metabolites through complex redox reactions and components, crucial for adapting to dynamic environments. The key role of oxidoreductases in plant physiological processes deserves further exploration. Adverse environmental conditions in the future may escalate oxidative damage, necessitating the development of new protection strategies.
PHYTOCHEMISTRY REVIEWS
(2021)
Review
Cell Biology
Hongli Li, Celien Lismont, Iulia Revenco, Mohamed A. F. Hussein, Claudio F. Costa, Marc Fransen
Summary: Peroxisomes contain enzymes involved in H2O2 production and degradation. Dysfunctional peroxisomes are removed through pexophagy, while H2O2 plays a role in mediating autophagic processes. Understanding the bidirectional relationship between peroxisomal H2O2 metabolism and autophagy is a key challenge in studying autophagy-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Xin Chang, Peng Gao, Quanfa Li, Hongming Liu, Huanhuan Hou, Shuang Wu, Jie Chen, Lu Gan, Ming Zhao, Dagan Zhang, Shuping Sun, Baojuan Wang
Summary: In this study, papain-encapsulated platinum nanoclusters exhibited intense green fluorescence, showing promising potential for lysozyme detection and bacterial differentiation. The accurate formation of papain-Pt NCs with good dispersity and stability suggests their suitability as fluorescent label-free nanoparticles for identifying Gram-positive bacteria.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Ricardo J. B. Leote, Caroline G. Sanz, Victor C. Diculescu
Summary: Shikonin, a natural compound, shows anti-oxidant and anti-cancer activity, as well as the ability to inhibit cancer cell dsDNA transcription/replication. This study investigates the electrochemical behavior of shikonin, as well as its interaction with dsDNA, using cyclic and differential pulse voltammetry and an electrochemical biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Kayla M. Valdes, Ganesh S. Sundar, Luis A. Vega, Ashton T. Belew, Emrul Islam, Rachel Binet, Najib M. El-Sayed, Yoann Le Breton, Kevin S. McIver
INFECTION AND IMMUNITY
(2016)
Article
Immunology
Luis A. Vega, Kayla M. Valdes, Ganesh S. Sundar, Ashton T. Belew, Emrul Islam, Jacob Berge, Patrick Curry, Steven Chen, Najib M. El-Sayed, Yoann Le Breton, Kevin S. McIver
INFECTION AND IMMUNITY
(2017)
Article
Biochemistry & Molecular Biology
Ganesh S. Sundar, Emrul Islam, Kanika Gera, Yoann Le Breton, Kevin S. McIver
MOLECULAR MICROBIOLOGY
(2017)
Article
Microbiology
Jeffrey A. Freiberg, Yoann Le Breton, Bao Q. Tran, Alison J. Scott, Janette M. Harro, Robert K. Ernst, Young Ah Goo, Emmanuel F. Mongodin, David R. Goodlett, Kevin S. McIver, Mark E. Shirtliff
Article
Microbiology
Yoann Le Breton, Ashton T. Belew, Jeffrey A. Freiberg, Ganesh S. Sundar, Emrul Islam, Joshua Lieberman, Mark E. Shirtliff, Herve Tettelin, Najib M. El-Sayed, Kevin S. McIver
Article
Microbiology
Stephan Brouwer, Amanda J. Cork, Cheryl-Lynn Y. Ong, Timothy C. Barnett, Nicholas P. West, Kevin S. McIver, Mark J. Walker
JOURNAL OF BACTERIOLOGY
(2018)
Article
Multidisciplinary Sciences
Kayla M. Valdes, Ganesh S. Sundar, Ashton T. Belew, Emrul Islam, Najib M. El-Sayed, Yoann Le Breton, Kevin S. McIver
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Ganesh S. Sundar, Emrul Islam, Rezia D. Braza, Aliyah B. Silver, Yoann Le Breton, Kevin S. McIver
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Microbiology
Vincent P. van Hensbergen, Elin Movert, Vincent de Maat, Christian Luchtenborg, Yoann Le Breton, Gerard Lambeau, Christine Payre, Anna Henningham, Victor Nizet, Jos A. G. van Strijp, Britta Bruegger, Fredric Carlsson, Kevin S. McIver, Nina M. van Sorge
Article
Biochemistry & Molecular Biology
Rebecca J. Edgar, Vincent P. van Hensbergen, Alessandro Ruda, Andrew G. Turner, Pan Deng, Yoann Le Breton, Najib M. El-Sayed, Ashton T. Belew, Kevin S. McIver, Alastair G. McEwan, Andrew J. Morris, Gerard Lambeau, Markj Walker, Jeffrey S. Rush, Konstantin Korotkov, Goran Widmalm, Nina M. van Sorge, Natalia Korotkova
NATURE CHEMICAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Ankita J. Sachla, John D. Heimann
NATURE COMMUNICATIONS
(2019)
Article
Genetics & Heredity
Heng Zhao, Ankita J. Sachla, John D. Helmann
Article
Biochemistry & Molecular Biology
Ephrahime S. Traore, Jiasong Li, Tapiwa Chiura, Jiafeng Geng, Ankita J. Sachla, Francis Yoshimoto, Zehava Eichenbaum, Ian Davis, Piotr J. Mak, Aimin Liu
Summary: The HupZ protein binds heme through its His(6)-tag, leading to heme-induced higher-order oligomeric structure and heme stacking. The results do not support the classification of HupZ as a heme oxygenase, as slow heme binding and weak heme degradation activity are associated with the His(6)-tag.
Review
Microbiology
Ankita J. Sachla, John D. Helmann
Summary: Synthesis of the bacterial cell envelope relies on regulated partitioning of resources from central metabolism and key metabolic junctions for precursor allocation. Enzymes like GlmS and MurA play critical roles in directing intermediates towards peptidoglycan synthesis, while shared resources such as lipid carriers and amino acids are essential for envelope assembly. Limited resources must be shared between cellular pathways, with potential benefits from metabolite scavenging or symbiotic relationships with hosts.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ankita J. Sachla, Yuanchan Luo, John D. Helmann
Summary: Cell physiology heavily relies on metalloenzymes, which can be disrupted by imbalances in metal ion pools. Bacillus subtilis requires manganese for growth and has mechanisms for import and efflux to maintain homeostasis. Dysfunctional cytochrome aa(3)-type quinol oxidase plays a central role in metal-induced intoxication.
MOLECULAR MICROBIOLOGY
(2021)