Article
Pharmacology & Pharmacy
Louiza Belkacemi, Yina Sun, Nissar A. Darmani
Summary: This study investigated the emetic potential and motor effects of temsirolimus and its analogs. It was found that temsirolimus has a dose-dependent emetic effect, with the optimal dose at 10 mg/kg. Higher doses had no significant effect. Temsirolimus also reduced motor activity in least shrews. The study suggests the promising antiemetic potential of temsirolimus and its analogs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huiling Sun, Kai Meng, Lin Hou, Lijun Shang, Jianqun Yan
Summary: GLP-2 is a hormone secreted from the gut and brainstem that can suppress food intake by influencing the hypothalamus through the nucleus tractus solitarius. The GLP-2 system in the nucleus tractus solitarius exerts an inhibitory action on food intake, mediated by MC4-R.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Rui Wang, Dan Fang, Tingting Lin, Wenhui Liang, Hu Qiao
Summary: The recent study found that aldosterone can play a non-genomic regulatory role in rapid sodium intake by activating G protein-coupled estrogen receptor at the NTS level, and it exhibits obvious time and concentration-dependent regulation. However, the molecular mechanism of how aldosterone regulates sodium intake rapidly is still unclear.
NEUROSCIENCE LETTERS
(2023)
Article
Clinical Neurology
Bindu Parayil Sankaran, Saskia B. Wortman, Michel A. Willemsen, Shanti Balasubramaniam
Summary: A 7-year-old girl with rare genetic disease MEGD(H)EL presented with worsening respiratory issues and required mechanical ventilation, with MRI showing progression of known changes in the disease. Despite being ventilator dependent, she eventually succumbed to the effects of the disease.
Article
Biochemistry & Molecular Biology
Xia Wang, Ruijuan Guan, Xiaomei Zhao, Jun Chen, Danian Zhu, Linlin Shen, Nana Song
Summary: TASKs, specifically TASK1 and TASK3, in orexin neurons play a crucial role in regulating respiratory chemoreflex, with orexin neurons sensing extracellular pH changes and projecting to the NTS to modulate respiration. Blocking TASKs or OX1R can affect breathing response to acidosis in the LH.
Article
Nutrition & Dietetics
Antonietta Canna, Elena Cantone, Anne Roefs, Sieske Franssen, Anna Prinster, Elia Formisano, Francesco Di Salle, Fabrizio Esposito
Summary: In this study, ultra-high field fMRI was used to investigate the neural signals in the Nucleus Tractus Solitarius (NTS) in response to different taste stimuli in the human brainstem. The results demonstrated a significant blood oxygen level-dependent (BOLD) response in the predicted location of the NTS for all basic taste stimuli. This study suggests the potential of using a similar experimental strategy to explore the central nervous system involvement in eating disorders.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Nilufer Sayar-Atasoy, Connor Laule, Iltan Aklan, Hyojin Kim, Yavuz Yavuz, Tayfun Ates, Ilknur Coban, Fulya Koksalar-Alkan, Jacob Rysted, Debbie Davis, Uday Singh, Muhammed Ikbal Alp, Bayram Yilmaz, Huxing Cui, Deniz Atasoy
Summary: This study investigates the role of norepinephrine in appetite regulation and identifies a novel ascending noradrenergic circuit that conveys hunger signals to the melanocortin pathway. The researchers found that norepinephrine levels in the paraventricular hypothalamic nucleus (PVN) increase with energy deficit signals and decrease with food access. They also discovered that the innervating catecholaminergic axon terminals from NTSTH-neurons target PVNMC4R-neurons and regulate appetite. These findings provide new insights into the mechanisms of appetite regulation.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Georgina K. C. Dowsett, Brian Y. H. Lam, John A. Tadross, Irene Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S. H. Yeo
Summary: This study provides a detailed single-cell level characterization of cells in the AP and NTS expressing receptors for key anti-obesity drugs, revealing their gene expression profiles under different nutritional states. The research also identifies the transcriptional sensitivity of oligodendrocytes to overnight fasting and shows that roughly half of GIPR-expressing cells are oligodendrocytes.
MOLECULAR METABOLISM
(2021)
Article
Biochemical Research Methods
Jaesub Park, Sangyeon Lee, Kwansoo Kim, Jaegyun Jung, Doheon Lee
Summary: In this study, a computational approach called LAPINE is proposed for large-scale prediction of ADR-related proteins. The results show that LAPINE is capable of predicting ADR-related proteins with high reliability, providing insights into the mechanism of ADRs and aiding in prevention. The source code of LAPINE is available on GitHub and Figshare.
Article
Neurosciences
Qiuping Ye, Si Yuan, Lulu Yao, Yong Dai, Bing Deng, Jiahui Hu, Jiao Qiao, Hongmei Wen, Zulin Dou, Nenggui Xu
Summary: This study aims to investigate the effect of nucleus tractus solitarius (NTS) on post-stroke dysphagia (PSD) treated by electroacupuncture. The results showed that excitatory neurons in the NTS were involved in the treatment process of PSD by electroacupuncture. Furthermore, it was found that inhibiting the NTS reduced the EMG signal associated with swallowing response induced by M1 activation in PSD mice, which was rescued by electroacupuncture.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Psychology, Biological
Motoi Kobashi, Yuichi Shimatani, Masako Fujita
Summary: We investigated the effects of anorectic substances on gastric reservoir function by examining the effects of oxytocin on the motility of the forestomach in rats. Oxytocin increased intragastric pressure in the forestomach in a dose-dependent manner and suppressed phasic contractions of the distal stomach. The involvement of the area postrema and/or medial nucleus of the nucleus tractus solitarius in these effects was confirmed.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Ashmita Mukherjee, Adrianne M. DiBrog, Elizabeth G. Mietlicki-Baase
Summary: Binge-like palatable food intake can reduce the expression of preproglucagon (PPG), the precursor for glucagon-like peptide-1 (GLP-1), in the hindbrain in male rats. However, it is unknown if similar effects occur in female rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Soledad Pitra, Bret N. Smith
Summary: This article discusses the importance of the brain stem dorsal vagal complex in regulating systemic glucose homeostasis and neuroplastic changes associated with systemic glucose alterations. It also explores the critical connection between these nuclei and the gut, as well as the role of central vagal circuits in the favorable outcomes of bariatric surgical procedures for metabolic disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Neurosciences
Anthony M. Downs, Zoe A. McElligott
Summary: This review discusses recent advances in understanding the role of the noradrenergic system in substance use disorders, including potential therapeutic targets and new treatment approaches.
Article
Engineering, Biomedical
Jiayue Cao, Xiaokai Wang, Terry L. Powley, Zhongming Liu
Summary: The study found that neurons in the nucleus tractus solitarius (NTS) exhibit high selectivity to the orientation of electrical stimulation, with the strongest responses observed when the current flows in parallel with the vagal intramuscular arrays (IMAs) underlying the smooth muscle fibers. This suggests that the orientation of gastric electrical stimulation (GES) plays a critical role in engaging vagal afferents effectively, and should be considered in light of the structural phenotypes of vagal terminals in the stomach.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Barbara C. Hansen, Sylvia Gografe, Stacy Pritt, Kai-lin Catherine Jen, Camille A. McWhirter, Susan M. Barman, Anthony Comuzzie, Molly Greene, Justin A. McNulty, Daniel Eugene Michele, Naz Moaddab, Randall J. Nelson, Karen Norris, Karen D. Uray, Ron Banks, Karin N. Westlund, Bill J. Yates, Jerald Silverman, Kenneth D. Hansen, Barbara Redman
Editorial Material
Neurosciences
Bill J. Yates
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Neurosciences
Derek M. Miller, William M. DeMayo, George H. Bourdages, Samuel R. Wittman, Bill J. Yates, Andrew A. McCall
EXPERIMENTAL BRAIN RESEARCH
(2017)
Review
Neurosciences
Susan M. Barman, Bill J. Yates
FRONTIERS IN NEUROSCIENCE
(2017)
Editorial Material
Neurosciences
Bill J. Yates
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Editorial Material
Neurosciences
Bill J. Yates
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Editorial Material
Physiology
Gina L. C. Yosten, Josephine C. Adams, Christina N. Bennett, Nigel W. Bunnett, Rita Scheman, Curt D. Sigmund, Bill J. Yates, Irving H. Zucker, Willis K. Samson
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Editorial Material
Neurosciences
Bill J. Yates
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ameya C. Nanivadekar, Derek M. Miller, Stephanie Fulton, Liane Wong, John Ogren, Girish Chitnis, Bryan McLaughlin, Shuyan Zhai, Lee E. Fisher, Bill J. Yates, Charles C. Horn
Article
Physiology
Derek M. Miller, Asmita Joshi, Emmanuel T. Kambouroglos, Isaiah C. Engstrom, John P. Bielanin, Samuel R. Wittman, Andrew A. McCall, Susan M. Barman, Bill J. Yates
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Editorial Material
Neurosciences
Bill J. Yates
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Clinical Neurology
John P. Bielanin, Nerone O. Douglas, Jonathan A. Shulgach, Andrew A. McCall, Derek M. Miller, Pooja R. Amin, Charles P. Murphey, Susan M. Barman, Bill J. Yates
FRONTIERS IN NEUROLOGY
(2020)
Article
Physiology
Charles P. Murphey, Jonathan A. Shulgach, Pooja R. Amin, Nerone K. Douglas, John P. Bielanin, Jacob T. Sampson, Charles C. Horn, Bill J. Yates
Summary: Nausea is difficult to distinguish in preclinical models, but based on human experience, emesis is usually preceded by nausea. The study focused on measuring gastrointestinal and cardiorespiratory changes prior to emesis to provide insights into markers for nausea. CuSO4 infusion elicited physiological changes in heart rate, respiratory rate, and intestinal electromyographic (EMG) activity, suggesting that monitoring of intestinal EMG activity, perhaps in combination with heart rate, may provide the best indicator of the onset of nausea.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Carey D. Balaban, Bill J. Yates
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2017)
Article
Physiology
Neesirg M. Patel, Ethan A. G. Baker, Samuel R. Wittman, Isaiah C. Engstrom, George H. Bourdages, Andrew A. McCall, Derek M. Miller, Bill. J. Yates
PHYSIOLOGICAL REPORTS
(2018)