Article
Biochemistry & Molecular Biology
Xuemin Chen, Yuan Liu, Linghao Kong, Ziyang Wen, Weize Wang, Chu Wang
Summary: A quantitative chemoproteomic platform based on mass shifts was developed to identify protein cross-links induced by MGO in proteomes. 66 cross-linked targets were identified, including components of functional complexes such as spliceosomes and ribosomes. The study also revealed that the active-site Cys331 played a critical role in mediating the cross-linking process.
ACS CHEMICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Anja Plemenitas Iljes, Vita Dolzan
Summary: Alcohol use disorder (AUD) is a prevalent and disabling disorder with various comorbidities. The relationship between alcohol metabolism and oxidative stress is not fully understood. Studies have shown that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.
Review
Endocrinology & Metabolism
Xiao Xu, Hao-Ran Shen, Jia-Rong Zhang, Xue-Lian Li
Summary: The IMPs, a highly conserved family of RNA binding proteins, play a crucial role in regulating RNA processing and are implicated in various physiological and pathological processes, including female reproductive pathophysiology and diseases such as PCOS, PE, GDM, and gynecological tumors.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Irabonosi Obomighie, Kestutis Lapenas, Billy E. Murphy, Alexander M. C. Bowles, Ulrike Bechtold, Filippo Prischi
Summary: The p70 ribosomal S6 kinase (S6K) family is a highly conserved group of kinases that regulate cell growth and stress response by modulating protein synthesis and ribosomal biogenesis. The plant S6K family consists of two isoforms, S6K1 and S6K2, which have distinct functions and regulation mechanisms despite their sequence similarity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jessica Maiuolo, Francesca Oppedisano, Cristina Carresi, Micaela Gliozzi, Vincenzo Musolino, Roberta Macri, Federica Scarano, Annarita Coppoletta, Antonio Cardamone, Francesca Bosco, Rocco Mollace, Carolina Muscoli, Ernesto Palma, Vincenzo Mollace
Summary: Reduced bioavailability of NO is associated with cardiovascular disease, and organic nitrates like GTN are commonly used to treat it. However, chronic use of GTN can lead to nitrate tolerance, requiring higher doses for the same effect. Nitrate tolerance is also accompanied by a decrease in ALDH2 catalytic activity. Introducing natural products containing nitrates into the diet can help reduce GTN intake and nitrate tolerance, while maintaining proper ALDH2 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Evelien Vanderlinden, Arnaud Marchand, Ria Van Berwaer, Wim van Dam, Philippe Arzel, Hugo Klaassen, Leentje Persoons, Patrick Chaltin, Lieve Naesens
Summary: CPD A is a novel inhibitor of influenza A and B virus replication and RNA synthesis with broad-spectrum activity. Its mechanism of action lies between 1 and 5 h p. i., similar to ribavirin.
ANTIVIRAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jiyoung Oh, Chungmo Koo, Kyung Won Kim, Jin-Sung Lee
Summary: PDH deficiency is an inherited metabolic disorder caused by a defect in the pyruvate dehydrogenase complex, with stress-induced gluconeogenesis potentially contributing to rapid disease exacerbation.
MEDICAL HYPOTHESES
(2021)
Article
Pharmacology & Pharmacy
Kaveri M. Adki, Yogesh A. Kulkarni
Summary: This study demonstrates the effectiveness of paeonol in the management of diabetic retinopathy. Paeonol treatment significantly improved retinal physiology, reduced blood glucose levels and oxidative stress, and alleviated histopathological changes in the retina.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yunmei Chai, Qingwen Ma, Xin Nong, Xinyue Mu, Aixiang Huang
Summary: This study reveals that the production of phenyllactic acid (PLA) by Lactiplantibacillus plantarum L3 is regulated by the LuxS/AI-2 Quorum Sensing (QS) system, providing a theoretical basis for the efficient and large-scale production of PLA in industries in the future.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Sisi Chen, Shimin Jia, Keke Suo, Qiaozhen Kang, Limin Hao, Laizheng Lu, Xin Liu, Jinyong Huang, Jike Lu
Summary: Exposure to environmental stresses enhances the adaptability of bacteria and up-regulates the expression of oxidative stress-related genes and antioxidant enzymes. This study evaluated the effects of untreated and ethanol-induced Lactococcus lactis intracellular extracts on alcohol metabolism in mice. The results showed that ethanol-induced intracellular extracts enhanced alcohol metabolism in mice and had potential benefits on liver health.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Mervi T. Hyvonen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Hakkinen, Marko Pietila, Marina B. Gottikh, Jouko Vepsalainen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinanen, Alex R. Khomutov
Summary: The polyamines spermine and spermidine are crucial for cell growth and function. This study demonstrates that a protein called OAZ1 inhibits polyamine uptake and targets an enzyme involved in polyamine biosynthesis for degradation. The study also reveals that polyamines induce the dimerization of OAZ1 and this dimerization is modulated by certain chemicals. These findings provide new insights into the regulation of polyamine homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Therese Terce-Laforgue, Jeremy Lothier, Anis M. Limami, Jacques Rouster, Peter J. Lea, Bertrand Hirel
Summary: The agronomic potential of glutamate dehydrogenase 2 (GDH2) in maize kernel production was investigated by examining the impact of a mutation on the corresponding gene. Heterozygous gdh2 mutant plants showed a decrease in root amino acid content and an increase in phenolic compounds in leaves. The heterozygous gdh2 mutant lines exhibited a 30 to 40% increase in kernel yield over two years of field cultivation.
Article
Biochemistry & Molecular Biology
Heeyoung Kang, Hyun Joo Shin, Hyeong Seok An, Zhen Jin, Jong Youl Lee, Jaewoong Lee, Kyung Eun Kim, Eun Ae Jeong, Kyu Yeong Choi, Catriona McLean, Kun Ho Lee, Soo Kyoung Kim, Hae Ryong Lee, Gu Seob Roh
Summary: The study revealed that LCN2 is involved in various amyloid toxicity mechanisms, particularly neuroinflammation and oxidative stress, in an AD mouse model.
Review
Immunology
Linfeng Zhu, Guoqin Tong, Fan Yang, Yijun Zhao, Guangjie Chen
Summary: Uremic neuropathy in children is a wide range of neurological disorders associated with progressive renal dysfunction. The diagnosis is often made retrospectively, and there are no defining signs or laboratory and imaging findings. These disorders contribute to increased morbidity and mortality among children, making uremia a global public health problem. Mechanistically, retention of uremic solutes, increased oxidative stress, neurotransmitter imbalance, and disturbance of the blood-brain barrier may cause uremic neuropathy. Neuroimmune factors and targeted anti-inflammatory therapy may provide new insights for the treatment of uremia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junjie Sun, Juil Kim, Hoyoung Jeong, Dasom Kwon, Yuseok Moon
Summary: This study investigates the impact of ribosomal insult on gut health and reveals that ribosomal insult leads to gut barrier disruption and accelerates the aging process. Activation of the Sek-1/p38 signaling pathway can mitigate the gut barrier damage caused by ribosomal insult, thus delaying the aging process. The study also demonstrates that ribosomal insult results in dysbiosis of the gut microbiota and increases the risk of bacterial exposure.
Article
Cell Biology
Canhua Huang, Qian Hao, Getao Shi, Xiang Zhou, Yu Zhang
Summary: BCL7C plays a tumor-suppressive role in ovarian cancer by inhibiting mutant p53 activity, leading to decreased cell proliferation and invasion in cancer cells. Low levels of BCL7C are associated with poor prognosis in ovarian cancer, suggesting its potential as a therapeutic target.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Cell Biology
Qian Hao, Jiaxiang Chen, Junming Liao, Yingdan Huang, Yu Gan, Sarit Larisch, Shelya X. Zeng, Hua Lu, Xiang Zhou
Summary: ARTS and p53 collaborate closely in mitochondria-engaged apoptosis, with ARTS inducing apoptosis by antagonizing anti-apoptotic proteins and p53 activating the expression of ARTS.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yingdan Huang, Bangxiang Xie, Mingming Cao, Hua Lu, Xiaohua Wu, Qian Hao, Xiang Zhou
Summary: The RNA component RMRP is highly expressed in various malignant cancers and associated with poor prognosis. It indirectly elevates AKT expression and promotes breast cancer progression, with AKT knockdown abolishing RMRP-induced cancer cell growth and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Qian Hao, Jiajia Li, Qinghua Zhang, Fei Xu, Bangxiang Xie, Hua Lu, Xiaohua Wu, Xiang Zhou
Summary: This study using single-cell transcriptomics analysis of HGSOC samples reveals new molecular features and potential therapeutic targets, which could advance the understanding and treatment of the disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Oncology
Qian Hao, Xiang Zhou
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Tao Han, Jing Tong, Mengxin Wang, Yu Gan, Bo Gao, Jiaxiang Chen, Youxun Liu, Qian Hao, Xiang Zhou
Summary: Olaparib is a widely used PARP inhibitor in the treatment of solid tumors. Its anti-tumor activity is achieved through the inhibition of PARP enzymes and blocking DNA repair. This study reveals that Olaparib activates the nucleolar stress-RPs-p53 pathway, leading to the activation of p53 and the inhibition of cancer cell survival and proliferation.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Cell Biology
Xiang Zhou, Ji Hoon Jung, Hua Lu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Qian Hao, Jiaxiang Chen, Hua Lu, Xiang Zhou
Summary: The tumor-suppressive activity of p53 is mainly due to its ability to induce cell death, specifically apoptosis, through various mechanisms. It transcriptionally activates pro-apoptotic genes and inhibits anti-apoptotic genes, leading to mitochondrial apoptosis. It also promotes mitochondrial apoptosis by directly interacting with BCL-2 family proteins in the mitochondria. ARTS, a pro-apoptotic protein encoded by an alternative spliced variant of the SEPT4 gene, facilitates BCL-2 and XIAP degradation, triggering apoptosis. ARTS is a new p53 target gene that enhances mitochondrial apoptosis by interacting with p53. This review discusses the mechanisms of p53-induced mitochondrial apoptosis, the role of ARTS in regulating mitochondrial cell death, and the clinical significance of ARTS in cancer and non-cancer diseases.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chen Xiong, Hong Ling, Qian Hao, Xiang Zhou
Summary: Cuproptosis is a newly identified form of copper-induced cell death that primarily affects cells relying on oxidative phosphorylation as their main energy source. This process involves copper binding to lipoylated proteins in the tricarboxylic acid cycle, leading to the aggregation of these proteins, destabilization of iron-sulfur cluster proteins, and proteotoxic stress. Cancer cells, on the other hand, predominantly utilize glycolysis and are resistant to cuproptosis. However, the tumor suppressor p53, which regulates metabolism, may have a role in cuproptosis regulation by influencing glycolysis and the biogenesis of iron-sulfur clusters and the copper chelator glutathione.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Cell Biology
Liping Guan, Qian Hao, Fenfen Shi, Bo Gao, Mengxin Wang, Xiang Zhou, Tao Han, Wenjie Ren
Summary: Circular RNA (circRNAs) is a circular non-coding RNA formed by back-splicing from precursor messenger RNA. It can be released and captured by other cell types, acting as connections between different cell types for signaling pathways. CircRNAs reshape the tumor microenvironment (TME) by regulating epithelial-stromal transformation, tumor vascularization, immune cell function, and inflammatory responses, playing a crucial role in cancer development.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yu Gan, Jun Deng, Qian Hao, Yingdan Huang, Tao Han, Jin-Guo Xu, Min Zhao, Litong Yao, Yingying Xu, Jianping Xiong, Hua Lu, Chunmeng Wang, Jiaxiang Chen, Xiang Zhou
Summary: In this study, it was found that UTP11 plays a crucial role in the biosynthesis of 18S ribosomal RNAs (rRNA) by binding to the pre-rRNA processing factor, MPP10. UTP11 is overexpressed in human cancers and is associated with poor prognoses. Depletion of UTP11 inhibits cancer cell growth through p53-dependent and -independent mechanisms, while UTP11 overexpression promotes cancer cell growth and progression. The study also reveals that UTP11 depletion triggers nucleolar stress and enhances ferroptosis, contributing to the inhibition of cancer cell survival and growth.
Article
Biochemistry & Molecular Biology
Litong Yao, Qian Hao, Mozhi Wang, Yuhai Chen, Hongyi Cao, Qiang Zhang, Keda Yu, Yizhou Jiang, Zhiming Shao, Xiang Zhou, Yingying Xu
Summary: In this study, researchers identified KLHL29 as a crucial tumor suppressor that regulates chemosensitivity in triple-negative breast cancer (TNBC). Low levels of KLHL29 were associated with unfavorable prognoses. Mechanistically, KLHL29 suppressed TNBC growth by degrading DDX3X and inhibiting cell cycle progression. The combination of DDX3X inhibitor RK33 and platinum-based chemotherapy showed promising results in suppressing TNBC.
Letter
Biology
Hanzhi Dong, Quan Liao, Bangxiang Xie, Yu-an Qiu, Zhiqiang Peng, Jun Deng, Jianping Xiong, Hua Lu, Qian Hao, Xiang Zhou
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Medicine, General & Internal
Bangxiang Xie, Qian Hao, Xiang Zhou, Dexi Chen
Summary: The HBx protein of hepatitis B virus interacts with the TAp63 protein and inhibits its transcriptional activity, leading to the progression of hepatocellular carcinoma with defective p53.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Hanchen Xu, Kevin Van der Jeught, Zhuolong Zhou, Lu Zhang, Tao Yu, Yifan Sun, Yujing Li, Changlin Wan, Ka Man So, Degang Liu, Michael Frieden, Yuanzhang Fang, Amber L. Mosley, Xiaoming He, Xinna Zhang, George E. Sandusky, Yunlong Liu, Samy O. Meroueh, Chi Zhang, Aruna B. Wijeratne, Cheng Huang, Guang Ji, Xiongbin Lu
Summary: The compound atractylenolide I (ATT-I) has been found to enhance tumor antigen presentation and boost the cytotoxic response of CD8(+) T cells by targeting the function of the immunoproteasome, ultimately improving the tumor response to immunotherapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
