Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

Coffee and Caffeine Protect against Liver Injury Induced by Thioacetamide in Male Wistar Rats

(2014) Kelly S. Furtado et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Curcumin Reorganizes miRNA Expression in a Mouse Model of Liver Fibrosis

(2013) Zeinab Korany Hassan et al.   Asian Pacific Journal of Cancer Prevention

Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats

(2013) Zahra A Amin et al.   BMC Complementary and Alternative Medicine

Translating an Understanding of the Pathogenesis of Hepatic Fibrosis to Novel Therapies

(2013) Don C. Rockey   Clinical Gastroenterology and Hepatology

Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-β

(2013) Jonathan Arauz et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro

(2013) Zili Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Salvianolic acid B inhibits hepatic stellate cell activation through transforming growth factor beta-1 signal transduction pathway in vivo and in vitro

(2013) Yan-Yan Tao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza

(2013) Ying Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model

(2013) Sung Gon Shim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Resolution of Liver Fibrosis by Isoquinoline Alkaloid Berberine in CCl4-Intoxicated Mice Is Mediated by Suppression of Oxidative Stress and Upregulation of MMP-2 Expression

(2013) Robert Domitrović et al.   JOURNAL OF MEDICINAL FOOD

Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection

(2013) Yasmeen M Attia et al.   Parasites & Vectors

Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation

(2013) Xiaotong Wang et al.   PHYTOMEDICINE

Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis

(2013) Qunyan Yao et al.   TOXICOLOGY LETTERS

Glycyrrhizic acid attenuates CCl4-induced hepatocyte apoptosis in ratsviaa p53-mediated pathway

(2013) Xiao-Ling Guo   WORLD JOURNAL OF GASTROENTEROLOGY

Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis

(2013) Sung Hwan Ki et al.   Journal of Ginseng Research

Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats

(2012) Qun-yan Yao et al.   BMC Complementary and Alternative Medicine

The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation

(2012) Miguel Angel Calleja et al.   BRITISH JOURNAL OF NUTRITION

Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress

(2012) Jianguo Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats

(2012) Devaraj Ezhilarasan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis

(2012) Chia-Cheng Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: Modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression

(2012) Chuan-tao Tu et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon Therapy

(2012) Michael W. Fried   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage

(2012) Jonathan Arauz et al.   JOURNAL OF APPLIED TOXICOLOGY

Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling

(2012) Rong Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Glycyrrhizin in patients who failed previous interferon alpha-based therapies: biochemical and histological effects after 52 weeks

(2012) M. P. Manns et al.   JOURNAL OF VIRAL HEPATITIS

Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway

(2012) Hong Xu et al.   LABORATORY INVESTIGATION

Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis

(2012) Naglaa M El-Lakkany et al.   Parasites & Vectors

Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride

(2012) Jann-Inn Tzeng et al.   PHYTOTHERAPY RESEARCH

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB

(2012) Wei-Chun Huang et al.   PLoS One

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

(2012) Haitao Shi et al.   TOXICOLOGY

Therapeutic targets in liver fibrosis

(2011) Jonathan A. Fallowfield   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

25-OCH3-PPD induces the apoptosis of activated t-HSC/Cl-6 cells via c-FLIP-mediated NF-κB activation

(2011) Yan-ling Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches

(2011) Elisabetta Mormone et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Differences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis C

(2011) S. J. Schrieber et al.   DRUG METABOLISM AND DISPOSITION

Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats

(2011) Yong-Han Paik et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Coffee prevents CCl4-induced liver cirrhosis in the rat

(2011) Mario G. Moreno et al.   Hepatology International

Oral application of 1,7-dimethylxanthine (paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis

(2011) Ildikó Klemmer et al.   HEPATOLOGY RESEARCH

Ginsenoside Rb1 Inhibits Cell Activation and Liver Fibrosis in Rat Hepatic Stellate Cells

(2011) Yu-Ting Lo et al.   JOURNAL OF MEDICINAL FOOD

Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats

(2011) Mohamed A. Morsy et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis

(2011) I-Shu Chen et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Differential Inhibitory Effects of Salvianolic Acids on Activation of Rat Hepatic Stellate Cells by Platelet-Derived Growth Factor

(2011) Ming-Kuei Tsai et al.   PLANTA MEDICA

Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis

(2011) Mohamed E. Shaker et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial

(2010) N. D. Freedman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Curcumin and Saikosaponin A Inhibit Chemical-Induced Liver Inflammation and Fibrosis in Rats

(2010) Shu-Ju Wu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis

(2010) Tzung-Yan Lee et al.   APOPTOSIS

Protective effect of a coffee preparation (Nescafe pure®) against carbon tetrachloride-induced liver fibrosis in rats

(2010) Hongyang Shi et al.   CLINICAL NUTRITION

Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment

(2010) Somchai Pinlaor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats

(2010) JiaWei Geng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis

(2010) Jian Hou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins

(2010) Paola Vitaglione et al.   HEPATOLOGY

Effect of Salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells

(2010) Zhigang Lv et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1

(2010) Hongxiang Qiao et al.   PHARMACEUTICAL BIOLOGY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Protective effects ofPhyllanthus amaruson fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity

(2010) B. Surya Narayanan et al.   TOXICOLOGY MECHANISMS AND METHODS

Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis

(2009) Xiao-dong Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis

(2009) Xu Sun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells

(2009) Qiaohua Kang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatic fibrosis

(2009) Jingjing Jiao et al.   CURRENT OPINION IN GASTROENTEROLOGY

Curcumin Eliminates Leptin’s Effects on Hepatic Stellate Cell Activation via Interrupting Leptin Signaling

(2009) Youcai Tang et al.   ENDOCRINOLOGY

About coffee, cappuccino and connective tissue growth factor—Or how to protect your liver!?

(2009) Olav A. Gressner   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats

(2009) Hongyang Shi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C

(2009) Roy L. Hawke et al.   JOURNAL OF CLINICAL PHARMACOLOGY

RETRACTED: Intraperitoneal application of caffeine prevents d-galactosamine-induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat

(2009) Olav A. Gressner et al.   JOURNAL OF HEPATOLOGY

Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells

(2009) Marco Trappoliere et al.   JOURNAL OF HEPATOLOGY

Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells

(2009) Jian-Chang Shu et al.   Journal of Natural Medicines

Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1

(2009) Qiaohua Kang et al.   LABORATORY INVESTIGATION

Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress

(2009) Jianguo Lin et al.   LABORATORY INVESTIGATION

Curcumin limits the fibrogenic evolution of experimental steatohepatitis

(2009) Francesco Vizzutti et al.   LABORATORY INVESTIGATION

Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells

(2009) Olav A. Gressner et al.   LIVER INTERNATIONAL

Study on antifibrotic effects of curcumin in rat hepatic stellate cells

(2009) Yun-Lian Lin et al.   PHYTOTHERAPY RESEARCH

Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats

(2009) Ming-Kuei Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis

(2009) Xiao-Dong Peng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Current and Future Anti-Fibrotic Therapies for Chronic Liver Disease

(2008) Don C. Rockey   Clinics in Liver Disease

The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease

(2008) Young-Suk Lim et al.   Clinics in Liver Disease

Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4in rats: role of TGF- modulation and oxidative stress

(2008) Karina Reyes-Gordillo et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor expression in hepatocytes via PPARγ and SMAD2/3-dependent pathways

(2008) Olav A. Gressner et al.   JOURNAL OF HEPATOLOGY

Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis

(2008) Tadashi Moro et al.   LIFE SCIENCES

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cellsin vitroby blocking NF-κB and ERK signalling

(2007) A Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

PROTECTION BY AND ANTI-OXIDANT MECHANISM OF BERBERINE AGAINST RAT LIVER FIBROSIS INDUCED BY MULTIPLE HEPATOTOXIC FACTORS

(2007) Ben-Jian Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Preventive effect of ethanol extract of Phyllanthus rheedii Wight. on d-galactosamine induced hepatic damage in Wistar rats

(2007) V. Suresh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Glycyrrhizin prevents of lipopolysaccharide/D-galactosamine-induced liver injury through down-regulation of matrix metalloproteinase-9 in mice

(2007) Kazuki Abe et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY