Article
Oncology
Loai Saleh Albinsaad, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn, Sae Byul Lee
Summary: This study aimed to investigate the relationship between p53 expression and the outcomes of neoadjuvant chemotherapy in HR-positive, HER2-negative breast cancer patients. The results showed that high expression of p53 was strongly associated with decreased overall survival and breast cancer-specific survival.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
Manjit K. Rana, Amrit Pal S. Rana, Utkarshni Khera
Summary: This study evaluated the prognostic significance of p16 and p53 overexpression in breast cancer, finding a significant correlation between p16 and p53 expression in breast carcinoma cases. p53 overexpression was associated with worse prognostic factors, while p16 expression was significantly correlated with the mitotic activity index.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Alanna B. Chan, Gian Carlo G. Parico, Jennifer L. Fribourgh, Lara H. Ibrahim, Michael J. Bollong, Carrie L. Partch, Katja A. Lamia
Summary: Disruption of circadian rhythms can increase the risk of various cancers. Mutations in the CRY2 gene found in human cancers have been shown to accelerate cell growth in mouse fibroblasts expressing high levels of c-MYC. These mutations also have divergent effects on circadian rhythms and interaction with SCFFBXL3.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Fang Tian, Jie Zhao, Qing-Fang Shi, Deng-Cai Zhang, Yue-Yuan Wang, Jian-Ping Sun, Yan Wang, Si-Ang Yang, Chong Zhang
Summary: The study explored the association between immunohistochemical markers and phyllodes tumor and found that CD10 expression was independently associated with PT and has the potential to be used as a differentiation marker.
Article
Oncology
Maryam Rasouli, Sara Khakshournia, Omid Vakili, Sanaz Dastghaib, Atefeh Seghatoleslam, Sayed Mohammad Shafiee
Summary: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. UBE2Q1, a newly identified ubiquitin-conjugating enzyme, is significantly expressed in colorectal tumors. The study suggests that UBE2Q1 may contribute to CRC progression by modulating the levels of p53 protein. Experimental results show that transfection of UBE2Q1 leads to a significant decrease in p53 protein levels in SW480 cells, while the change in p53 protein levels is not significant in LS180 cells. This indicates that UBE2Q1 may promote CRC progression by interacting with and degrading p53 protein.
Article
Otorhinolaryngology
Monica Pentenero, Patrizio Castagnola, Faride Victoria Castillo, Elena Isaevska, Samuele Sutera, Sergio Gandolfo
Summary: This prospective observational study examined the factors associated with malignant transformation in localized oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL). Data on demographics, clinical characteristics, histology, and DNA ploidy status were collected. The presence of OED, DNA ploidy, clinical presentation, and lesion site were found to be associated with malignant transformation in patients with OL, while none of these predictors were associated with PVL. The study suggests that DNA ploidy may be able to identify a subset of OL with low or minimal risk of malignant transformation, but it is not a reliable predictor in PVL patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Dentistry, Oral Surgery & Medicine
V. L. Brasileiro Junior, C. F. W. Nonaka, A. K. G. Gonzaga, C. C. de Oliveira Ramos, L. Pereira Pinto, L. B. Souza
Summary: This study investigated the expression of REG gamma, p53, MDM-2, Bcl-2, and Bax in OTSCC and correlated the findings with clinicopathological parameters. Lower expression of REG gamma was associated with lymph node metastasis and high-grade tumors, while lower expression of Bcl-2 was associated with high-grade OTSCC and disease-related death.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Engineering, Biomedical
Zaofeng Yang, Marianne M. M. Lee, Michael K. Chan
Summary: The study demonstrates that Pos3Aa crystals can serve as an efficient vehicle for delivering proteins into cells, reversing the inactivation of potential cancer therapeutics and making them more sensitive to chemotherapy drugs.
Article
Dentistry, Oral Surgery & Medicine
Lauren Frenzel Schuch, Jose Alcides Almeida De Arruda, Karolina Skarlet Silva Viana, Patricia Carlos Caldeira, Mauro Henrique Nogueira Guimaraes Abreu, Vanessa Fatima Bernardes, Maria Cassia Ferreira de Aguiar
Summary: This study assessed the expression of DNA damage response proteins in smokers and non-smokers with oral squamous cell carcinoma (OSCC). The results showed that smoking status did not significantly affect the expression of these proteins. There was also no significant association between protein expression and clinicopathological data.
BRAZILIAN ORAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao
Summary: This article provides an update on the roles of aberrant DNA methylation in endometrial carcinogenesis and discusses the opportunities and challenges of utilizing DNA methylation in the management and prevention of endometrial cancer.
Review
Biochemistry & Molecular Biology
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan
Summary: Ovarian cancers are a type of tumor that originates from different cells of the ovary and account for around 4% of all cancers in women worldwide. There are more than 30 identified tumor types based on cellular origins, with epithelial ovarian cancer (EOC) being the most common and deadly type. EOC can be further categorized into different subtypes. The development of ovarian cancer has long been associated with endometriosis, a chronic inflammation leading to the accumulation of mutations. Recent studies have elucidated the role of somatic mutations and their impact on altered tumor metabolism. Several oncogenes and tumor suppressor genes have been implicated in ovarian cancer progression. This review highlights the genetic alterations and their impact on metabolic networks in ovarian cancer, providing insights into potential personalized therapies.
Article
Oncology
Qizheng Wang, Yang Zhang, Enlong Zhang, Xiaoying Xing, Yongye Chen, Ke Nie, Huishu Yuan, Min-Ying Su, Ning Lang
Summary: This study aimed to evaluate the significance of VEGF and p53 for predicting PFS in patients with spinal GCTB and construct models based on clinical and CT radiomics to identify high-risk patients. The results showed that p53 and VEGF were independent prognostic factors affecting PFS. Radiomics models were able to effectively predict these two biomarkers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
F. Ayala de la Pena, B. Ortiz-Munoz, T. Quintanar-Verduguez, J. D. Santotoribio, S. de la Cruz, J. Trape-Pujol, E. Galve-Calvo, J. M. Auge-Fradera, J. Garcia-Gomez, A. Gonzalez-Hernandez
Summary: This article summarizes the use and interpretation of circulating tumor markers in breast cancer, focusing on their relationship with molecular subtypes and prognostic value. It also proposes a series of recommendations to improve the clinical utility of TMs.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Pathology
Christophe Bontoux, Veronique Hofman, Milissa Abboute, Virginie Lespinet-Fabre, Salome Lalvee, Samantha Goffinet, Olivier Bordone, Elodie Long-Mira, Sandra Lassalle, Florent Murcy, Guylene Rignol, Simon Heeke, Marius Ilie, Paul Hofman
Summary: This study retrospectively assessed the correlation between c-Met expression and clinicopathological and molecular features in non-small cell lung cancer patients. The results showed that c-Met-positive cases were more likely to have lymph node and/or visceral metastases, and high c-Met expression was more common in adenocarcinomas and correlated with high PD-L1 expression. These findings suggest that systematic c-Met testing in NSCLC patients is feasible and important.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Jussara Maria Goncalves, Luiz Henrique Godoi Marola, Daniella Serafin Couto Vieira, Filipe Modoloa, Rogerio Gondak
Summary: Low-Grade Myofibroblastic sarcoma (LGMS) is an extremely rare malignant tumor of myofibroblasts, and there has been growing interest in its study. This paper presents a case report of intrabuccal LGMS and provides a comprehensive review of the literature and immunohistochemical panel for diagnosing this entity, given the challenging nature of histopathological diagnosis.