Article
Medical Laboratory Technology
Lisa M. Johnson, Michael Spannagl, Nathalie Wojtalewicz, Juergen Durner
Summary: The study found that there is high variability in quantitative results between different manufacturers in fecal calprotectin assays, but qualitative interpretation in fecal pancreatic elastase assays seems to be harmonized across different manufacturers.
CLINICAL BIOCHEMISTRY
(2022)
Review
Gastroenterology & Hepatology
Chunsu Jiang, Jodie A. Barkin, Jamie S. Barkin
Summary: According to the systematic review and meta-analysis, the prevalence of exocrine pancreatic insufficiency (EPI) in newly diagnosed celiac disease (CD) patients is 26.2%, while in CD patients treated with a gluten-free diet (GFD), the prevalence is 8%. CD patients on GFD with persistent symptoms have a significantly higher rate of EPI (28.4%) compared to asymptomatic CD patients on GFD (3%).
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Ali Surmelioglu, Ersan Ozkardesler, Metin Tilki, Murat Yekrek
Summary: This study aimed to reveal the prevalence and possible causes of Exocrine Pancreatic Insufficiency (EPI) in gastric cancer patients who underwent subtotal or total gastrectomy, with completed oncological treatments and long-term disease-free survival success. Results showed that EPI can be seen in more than half of patients with gastric cancer after curative gastrectomy, with low FE-1 levels associated with factors such as chemoradiotherapy, lower serum protein and lipase levels, higher Maastricht indexes, and lower gastrointestinal quality of life scores.
Article
Peripheral Vascular Disease
Mohammed Siddiqui, Lonnie Hannon, Zhixin Wang, Jessica Blair, Suzanne Oparil, Sonya L. Heath, Edgar T. Overton, Paul Muntner
Summary: This study found that the association between hypertension and cardiovascular disease (CVD), including acute myocardial infarction (AMI), stroke, and heart failure, differs between individuals with and without HIV. Hypertension is associated with a higher risk of CVD in individuals with HIV. This study emphasizes the high CVD risk associated with hypertension among individuals with HIV.
Article
Gastroenterology & Hepatology
Sara P. Wyness, Heather A. Nelson, Ryan Jensen, Joseph Bird, Tenzin Norgyal, Hailey Hall, Lisa M. Johnson
Summary: In this study, a new pancreatic elastase assay was evaluated and found to be comparable to a well-known method. Pancreatic elastase assays are useful for detecting severe EPI but less accurate in classifying mild/moderate EPI.
Article
Gastroenterology & Hepatology
Anne F. Peery, Seth D. Crockett, Caitlin C. Murphy, Elizabeth T. Jensen, Hannah P. Kim, Matthew D. Egberg, Jennifer L. Lund, Andrew M. Moon, Virginia Pate, Edward L. Barnes, Courtney L. Schlusser, Todd H. Baron, Nicholas J. Shaheen, Robert S. Sandler
Summary: Gastrointestinal diseases in the United States result in significant healthcare utilization and expenditures, with millions of healthcare encounters and hundreds of thousands of deaths each year. To address this burden, focused clinical and public health efforts, along with increased research funding, are necessary.
Article
Endocrinology & Metabolism
Manuela Bruene, Ute Linnenkamp, Silke Andrich, Linda Jaffan-Kolb, Heiner Claessen, Charalabos-Markos Dintsios, Imke Schmitz-Losem, Johannes Kruse, Nadja Chernyak, Mickael Hiligsmann, Norbert Hermanns, Andrea Icks
Summary: Patients with comorbid depression and diabetes had higher total healthcare costs, with relatively higher mental health care costs compared to patients without depression. Excess costs were significantly associated with comorbidities.
Article
Genetics & Heredity
Denis Nguyen, Ophir Gilad, Christine M. Drogan, Zoe Eilers, Chuanhong Liao, Sonia S. Kupfer
Summary: This study aimed to determine the perception of pancreatic ductal adenocarcinoma (PDAC) risk in at-risk individuals and assess factors associated with PDAC surveillance uptake. The study found that individuals at risk for PDAC do not accurately perceive their risk, highlighting the need for counseling and personalized management to improve surveillance uptake for eligible individuals.
JOURNAL OF MEDICAL GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Joon Kim, Chang-Myung Oh, Hyeongseok Kim
Summary: The interplay between adipokines and pancreatic beta cells is crucial for regulating metabolic homeostasis and plays a role in the pathogenesis of type 2 diabetes and metabolic diseases.
Article
Medical Laboratory Technology
Yair Huta, Olga Ashorov, Dalal Hamouda, Doron Boltin, Ram Dickman, Tsachi Tsadok Perets
Summary: This study compared the performance of a new CLIA machine kit to the standard ELISA assay for measuring FPE1 levels in stool samples. The CLIA system demonstrated good laboratory performance and could be used for both qualitative and quantitative analysis of FPE1 in clinical settings.
CLINICAL LABORATORY
(2022)
Article
Health Care Sciences & Services
Dorin Nicolae Gheorghe, Adrian Camen, Dora Maria Popescu, Cerasella Sincar, Allma Pitru, Claudiu Marinel Ionele, Flavia Mirela Nicolae, Claudia Monica Danilescu, Alexandra Roman, Cristina Florescu
Summary: Comprehensive research has shown a definite connection between periodontal and systemic conditions, leading to precise diagnosis and individualized treatment for periodontitis patients. The pathogenic connections between periodontal disease and metabolic/digestive tract conditions are important to consider, as any conditions affecting oral cavity health can impact a patient's metabolic and gastrointestinal status. Therefore, periodontal screening and monitoring of metabolic and digestive status in periodontitis patients are crucial.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Djordje Jevtic, Igor Dumic, Terri Nordin, Amteshwar Singh, Nadezda Sulovic, Milan Radovanovic, Mladen Jecmenica, Tamara Milovanovic
Summary: DRESS syndrome is a severe cutaneous drug reaction that can involve internal organ damage and high mortality rates, with lesser-known gastrointestinal complications such as pancreatitis and various types of diabetes. This review focuses on synthesizing data on these rare manifestations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Lan Feng, Yuhao Wang, Daojun Zeng, Maohua Wang, Xiaoxia Duan
Summary: To evaluate the effect of overall peripheral inflammatory levels on cognitive function, this study reviewed and summarized observational studies on the relationship between biomarkers of peripheral inflammation (CRP, IL-6, and TNF-alpha) and cognitive decline. The results showed that individuals with high levels of peripheral inflammation had a 14% higher risk of subsequent cognitive decline. This study further demonstrates the link between systemic inflammation and cognitive status.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel A. P. Gutmann, Susanne Rospleszcz, Wolfgang Rathmann, Christopher L. Schlett, Annette Peters, Christian Wachinger, Sergios Gatidis, Fabian Bamberg
Summary: By investigating the radiomics features of hepatic fat, potential imaging biomarkers for T2DM and MetS can be identified, showing good predictive performance and outperforming RF models trained on benchmark parameters PDFF and BMI.
ACADEMIC RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Arwa Banjar, Rusha Alyafi, Ali AlGhamdi, Mohammad Assaggaf, Ammar Almarghlani, Shaymaa Hassan, Brian Mealey
Summary: Glycemic control is important for the relationship between periodontitis and diabetes. A study investigated the association between periodontitis stage and HbA1c levels in normoglycemic patients. 135 patients without diabetes were included, and higher HbA1c levels were associated with different stages of periodontitis. Periodontitis was significantly associated with elevated HbA1c levels in patients not previously diagnosed with diabetes, especially in stage III and IV periodontitis patients.
Article
Pharmacology & Pharmacy
Jan K. Nowak, Cyntia J. Szymanska, Jaroslaw Walkowiak
Summary: In this study, an unsupervised differential correlation network reanalysis of rectal transcriptomic data revealed promising targets for mechanistic research of intestinal pathology in cystic fibrosis (CF), including FAU, SRP14, and GDI2. These genes may be involved in a compensatory protein trafficking mechanism in the CF rectum, highlighting their potential therapeutic value.
Review
Genetics & Heredity
Laura Niiranen, Dawid Leciej, Hanna Edlund, Carolina Bernhardsson, Magdalena Fraser, Federico Sanchez Quinto, Karl-Heinz Herzig, Mattias Jakobsson, Jaroslaw Walkowiak, Olaf Thalmann
Summary: Epigenetic changes play a major role in fundamental metabolic pathways and have been closely linked to various diseases. This review focuses on the study of epigenetic changes in animals, with a special emphasis on human DNA methylation using ancient and modern genomes. Through ancient DNA research, we can infer past epigenetic changes and gain a comprehensive understanding of how our ancestors adapted to the changing environment and modified their lifestyles. However, working with ancient DNA presents challenges, but new paleoepigenomic data holds promise for future studies.
Article
Medicine, General & Internal
Jan Krzysztof Nowak, Patrycja Krzyzanowska-Jankowska, Slawomira Drzymala-Czyz, Joanna Gozdzik-Spychalska, Irena Wojsyk-Banaszak, Wojciech Skorupa, Ewa Sapiejka, Anna Miskiewicz-Chotnicka, Jan Brylak, Barbara Zielinska-Psuja, Aleksandra Lisowska, Jaroslaw Walkowiak
Summary: This study aimed to assess the effectiveness of a liposomal fat-soluble vitamin formulation containing vitamin K2 in the treatment of cystic fibrosis (CF). The results showed that the liposomal formulation was superior to the standard form in delivering vitamin D3 and E, as well as improving vitamin K-dependent carboxylation and vitamin A status in CF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Physiology
Karolina Wielgus, Mikolaj Danielewski, Jaroslaw Walkowiak
Review
Genetics & Heredity
Mikolaj Danielewski, Joanna Zuraszek, Aleksandra Zielinska, Karl-Heinz Herzig, Ryszard Slomski, Jaroslaw Walkowiak, Karolina Wielgus
Summary: Paleogenetics has undergone significant changes since its inception. Initially, limited molecular techniques hindered ancient DNA analysis. However, advancements in scientific tools, as well as the popularity of this field, have led to remarkable achievements. Breakthroughs in next-generation sequencing technologies and DNA isolation protocols have enabled the sequencing of whole genomes even from highly fragmented aDNA samples.
Article
Food Science & Technology
Krzysztof Dziedzic, Szymon Kurek, Grazyna Podolska, Slawomira Drzymala-Czyz, Sylwia Mildner-Szkudlarz, Wei Sun, Jaroslaw Walkowiak
Summary: This study investigated the content of phytosterols, squalene, and tocopherols in four varieties of common buckwheat grains and analyzed the effects of different tillage and nitrogen doses on grain yield and composition.
Article
Pediatrics
Jan Brylak, Jan K. K. Nowak, Mariusz Szczepanik, Magdalena Holubiec, Pawel Kurzawa, Jaroslaw Walkowiak
Summary: In children, there is a positive correlation between blood eosinophil count and colonic eosinophil mucosal density. This association is more pronounced in patients with systemic inflammation and older than 12.4 years.
Article
Medicine, General & Internal
Urszula Daniluk, Paulina Krawiec, Elzbieta Pac-Kozuchowska, Lukasz Dembinski, Jan Stanislaw Bukowski, Aleksandra Banaszkiewicz, Anna Wozniuk-Kazmierczak, Elzbieta Czkwianianc, Jan Brylak, Jaroslaw Walkowiak, Agnieszka Borys-Iwanicka, Anna Kofla-Dlubacz, Tomasz Pytrus, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn
Summary: The coexistence of inflammatory bowel disease (IBD) with pancreatic pathology is rare in children. A retrospective analysis of data from 1538 children diagnosed with IBD in 2014-2021 found that 11.4% of them had pancreatic involvement (PI), with acute pancreatitis (AP) diagnosed in 43.8% and asymptomatic hyperlipasemia (HL) or hyperamylasemia (HA) observed in 50.0%. Routine monitoring of pancreatic enzymes should be performed in patients with IBD, especially after the initiation of azathioprine (AZA) treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Emilia Dybska, Jan Krzysztof Nowak, Jaroslaw Walkowiak
Summary: The study investigates the transcriptomic context of RUNX3 expression in blood monocytes and reveals its strong associations with genes involved in cell growth, signal transduction, and chromosome organization. The findings suggest that RUNX3 plays a role in regulating cell function and immune response.
Article
Biochemistry & Molecular Biology
Anna Gosciniak, Piotr Szulc, Waldemar Zielewicz, Jaroslaw Walkowiak, Judyta Cielecka-Piontek
Summary: Red clover, a raw material with isoflavone content, was studied to evaluate the properties of its leaves and flowers. The study found that the ability to inhibit α-glucosidase, lipase, collagenase and antioxidant activity was not correlated with isoflavone content.
Review
Health Care Sciences & Services
Kamila Bokayeva, Malgorzata Jamka, Michalina Banaszak, Aleksandra Makarewicz-Bukowska, Ada Adamczak, Maria Chrobot, Adrianna Janicka, Natalia Jaworska, Jaroslaw Walkowiak
Summary: Folic acid may have a positive effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.
Article
Medicine, General & Internal
Malgorzata Jamka, Agata Czochralska-Duszynska, Edyta Madry, Aleksandra Lisowska, Katarzyna Jonczyk-Potoczna, Judyta Cielecka-Piontek, Pawel Bogdanski, Jaroslaw Walkowiak
Summary: This study aimed to evaluate the effects of CLA supplementation on bone mineral density and content in overweight or obese women. The results showed that three-month CLA supplementation did not improve bone health in this population. However, long-term intervention studies are needed to further investigate the potential benefits of CLA on bone health.
MEDICINA-LITHUANIA
(2023)
Review
Health Care Sciences & Services
Aleksandra Makarewicz, Malgorzata Jamka, Jakub Geltz, Angelika Smidowicz, Marta Kokot, Nina Kaczmarek, Edyta Madry, Jaroslaw Walkowiak
Summary: This meta-analysis compared the effects of endurance, strength, and combined training on inflammatory markers and adipokine concentrations in overweight and obese adults. The findings suggest that endurance training is more effective than strength training in reducing CRP, IL-6, and visfatin concentrations, while combined training is more beneficial in reducing TNF-alpha levels. There were no differences between the effects of different types of training on adiponectin and leptin concentrations. Further studies are needed to determine the optimal training for adiponectin and leptin concentrations in this population.
Review
Health Care Sciences & Services
Maria Wasiewicz-Gajdzis, Malgorzata Jamka, Jakub Geltz, Kamila Bokayeva, Lukasz Kaluzny, Joanna Jaglowska, Jaroslaw Walkowiak
Summary: This study compared the anthropometric parameters of patients with fatty acid oxidation disorders (FAOD) and healthy controls, finding a higher prevalence of abnormal body weight (overweight and obesity) in the FAOD group. Significant differences in body weight percentiles, BMI, BMI percentiles, and BMI z-scores were observed between FAOD patients and controls in the cohort. However, the meta-analysis did not show any differences in weight and BMI in all tested subgroups. Caution should be exercised when interpreting these results due to the low quality of evidence, small sample sizes, and significant heterogeneity of the included data.
Article
Health Care Sciences & Services
Malgorzata Jamka, Sylwia E. Piotrowska-Brudnicka, Joanna Karolkiewicz, Damian Skrypnik, Pawel Bogdanski, Judyta Cielecka-Piontek, Gulnara Sultanova, Jaroslaw Walkowiak, Edyta Madry
Summary: This pilot study compared the effect of endurance and endurance-strength training on body composition and bone metabolism in centrally obese women, with endurance-strength training showing more effectiveness in increasing lean mass.