The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease

Cholesterol and Amyloid-β: Evidence for a Cross-Talk between Astrocytes and Neuronal Cells

(2018) Elisa Canepa et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Sphingomyelins are Associated with Cognitive Progression in Alzheimer's Disease

(2018) Michelle M. Mielke et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered NEP2 Expression and Activity in Mild Cognitive Impairment and Alzheimer's Disease

(2018) Jeffrey Y. Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial

(2018) Philip Scheltens et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

(2018) Valery Filippov et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet

(2018) Narayan R. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β42 by Human Microglia and Decrease Inflammatory Markers

(2018) Erik Hjorth et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide Aβ25–35: Involvement of Lipid Rafts

(2017) Paula Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

(2017) Virginia Martín et al.   JOURNAL OF ALZHEIMERS DISEASE

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease

(2013) Hirosha Geekiyanage et al.   NEUROBIOLOGY OF AGING

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

An Approach to Glycobiology from Glycolipidomics: Ganglioside Molecular Scanning in the Brains of Patients with Alzheimer^|^#8217;s Disease by TLC-Blot/Matrix Assisted Laser Desorption/Ionization-Time of Flight MS

(2012) Takao Taki   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Altered Distribution of the Gangliosides GM1 and GM2 in Alzheimer’s Disease

(2012) Z. Pernber et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

(2012) Xiangnan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased concentration of the CSF Tau protein and its phosphorylated form in the late juvenile metachromatic leukodystrophy form: a case report

(2012) Joanna Tarasiuk et al.   JOURNAL OF NEURAL TRANSMISSION

Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-  Peptide

(2012) S. Keilani et al.   JOURNAL OF NEUROSCIENCE

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Implication of common and disease specific variants in CLU, CR1, and PICALM

(2012) Raffaele Ferrari et al.   NEUROBIOLOGY OF AGING

Statins Reduce Amyloid β-Peptide Production by Modulating Amyloid Precursor Protein Maturation and Phosphorylation Through a Cholesterol-Independent Mechanism in Cultured Neurons

(2012) Ai Hosaka et al.   NEUROCHEMICAL RESEARCH

Dual Effects of Statins on Aß Metabolism: Upregulation of the Degradation of APP-CTF and Aß Clearance

(2012) Naoyuki Sato et al.   Neurodegenerative Diseases

Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer’s disease

(2012) Tomoko Kurata et al.   NEUROLOGICAL RESEARCH

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

(2012) M. Kosicek et al.   NEUROSCIENCE LETTERS

Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

(2012) Marcus O. W. Grimm et al.   PLoS One

Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice

(2012) Virginie F. Labrousse et al.   PLoS One

Free Cholesterol Induces Higher β-Sheet Content in Aβ Peptide Oligomers by Aromatic Interaction with Phe19

(2012) Xiaolin Zhou et al.   PLoS One

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease

(2011) Andrey Y. Abramov et al.   AGING CELL

Attenuated atherogenesis in apolipoprotein E-deficient mice lacking amyloid precursor protein

(2011) Tim J.L. Van De Parre et al.   ATHEROSCLEROSIS

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains

(2011) Leila Hejazi et al.   BIOCHEMICAL JOURNAL

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

Plasma Clusterin and the Risk of Alzheimer Disease

(2011) Elisabeth M. C. Schrijvers   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

(2011) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

(2011) Frauke Glöckner et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

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(2011) Adriana Ferreira et al.   MOLECULAR MEDICINE

Loss of amyloid precursor protein in a mouse model of Niemann–Pick type C disease exacerbates its phenotype and disrupts tau homeostasis

(2011) Ana Nunes et al.   NEUROBIOLOGY OF DISEASE

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

(2011) M. Sano et al.   NEUROLOGY

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes

(2011) Justin A. Lemkul et al.   PROTEIN SCIENCE

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Focal demyelination in Alzheimer’s disease and transgenic mouse models

(2010) Stanislaw Mitew et al.   ACTA NEUROPATHOLOGICA

Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial

(2010) Philip Scheltens et al.   Alzheimers & Dementia

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain

(2010) Suqing Wang et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of cholesterol efflux by amyloid β secretion

(2010) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

 -Secretase-dependent amyloid-  is increased in Niemann-Pick type C: A cross-sectional study

(2010) N. Mattsson et al.   NEUROLOGY

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases

(2010) Oshrit Ben-David et al.   NEUROMOLECULAR MEDICINE

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

(2009) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The interaction of beta-amyloid protein with cellular membranes stimulates its own production

(2009) Imke Peters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Clusterin: A forgotten player in Alzheimer's disease

(2009) Tapio Nuutinen et al.   BRAIN RESEARCH REVIEWS

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

(2009) Hyang-Sook Hoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increased Membrane Cholesterol Might Render Mature Hippocampal Neurons More Susceptible to  -Amyloid-Induced Calpain Activation and Tau Toxicity

(2009) A. M. Nicholson et al.   JOURNAL OF NEUROSCIENCE

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix–loop–helix transcription factors and cell cycle in neural stem cells

(2009) M. Katakura et al.   NEUROSCIENCE

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

(2008) Naoki Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Polyunsaturated fatty acid–cholesterol interactions: Domain formation in membranes

(2008) Stephen R. Wassall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Active γ-secretase is localized to detergent-resistant membranes in human brain

(2008) Ji-Yeun Hur et al.   FEBS Journal

Up-and-down topological mode of amyloid β-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters

(2008) Maho Utsumi et al.   GLYCOCONJUGATE JOURNAL

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

(2008) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding cassette transporter A7 regulates processing of amyloid precursor proteinin vitro

(2008) Sharon L. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Sulfatides facilitate apolipoprotein E-mediated amyloid- peptide clearance through an endocytotic pathway

(2008) Youchun Zeng et al.   JOURNAL OF NEUROCHEMISTRY

Docosahexaenoic acid disruptsin vitroamyloid β1-40fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer’s disease model rats

(2008) Michio Hashimoto et al.   JOURNAL OF NEUROCHEMISTRY

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Role and Metabolism of Sulfatide in the Nervous System

(2008) Matthias Eckhardt   MOLECULAR NEUROBIOLOGY

Gender-dependent accumulation of ceramides in the cerebral cortex of the APPSL/PS1Ki mouse model of Alzheimer’s disease

(2008) Laurence Barrier et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

(2008) Hua Cheng et al.   NEUROBIOLOGY OF AGING

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Docosahexaenoic Acid Significantly Stimulates Immediate Early Response Genes and Neurite Outgrowth

(2008) L. Dagai et al.   NEUROCHEMICAL RESEARCH

Cholesterol Potentiates β-Amyloid-Induced Toxicity in Human Neuroblastoma Cells: Involvement of Oxidative Stress

(2008) Patricia Ferrera et al.   NEUROCHEMICAL RESEARCH

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

(2008) Chih-Chiang Chiu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain

(2008) Lubica Cibickova et al.   STEROIDS

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

(2007) Veera Venkata Ratnam Bandaru et al.   NEUROBIOLOGY OF AGING