Role of the Plasma Membrane Transporter of Organic Cations OCT1 and Its Genetic Variants in Modern Liver Pharmacology

Human Organic Cation Transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as Disposition Pathways for Fluoroquinolone Antimicrobials

(2013) Aditi Mulgaonkar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Expression ofSLC22A1variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib

(2013) Elisa Herraez et al.   HEPATOLOGY

Downregulation of organic cation transporter 1 (SLC22A1) is associated with tumor progression and reduced patient survival in human cholangiocellular carcinoma

(2013) ANJA LAUTEM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3

(2013) Monica Sala-Rabanal et al.   MOLECULAR PHARMACEUTICS

Kidney Transplantation Down-Regulates Expression of Organic Cation Transporters, Which Translocate β-Blockers and Fluoroquinolones

(2013) Giuliano Ciarimboli et al.   MOLECULAR PHARMACEUTICS

Pretherapeutic Expression of the hOCT1 Gene Predicts a Complete Molecular Response to Imatinib Mesylate in Chronic-Phase Chronic Myeloid Leukemia

(2012) Luciana Nardinelli et al.   ACTA HAEMATOLOGICA

Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake

(2012) Min-Koo Choi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia

(2012) A. Giannoudis et al.   BLOOD

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance

(2012) Michael Heise et al.   BMC CANCER

Genetic Variants in Genes Involved in Mechanisms of Chemoresistance to Anticancer Drugs

(2012) J. J.G. Marin et al.   CURRENT CANCER DRUG TARGETS

Organic Cation Transporters: Physiology, Toxicology and Special Focus on Ethidium as a Novel Substrate

(2012) Wing-Kee Lee et al.   CURRENT DRUG METABOLISM

Thiamine is a substrate of organic cation transporters in Caco-2 cells

(2012) Clara Lemos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial

(2012) Jordi Bruix et al.   JOURNAL OF HEPATOLOGY

No Correlation between the Expression of FXR and Genes Involved in Multidrug Resistance Phenotype of Primary Liver Tumors

(2012) P. Martinez-Becerra et al.   MOLECULAR PHARMACEUTICS

Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients

(2012) Linda Tarasova et al.   Pharmacogenetics and Genomics

Lamotrigine is a substrate for OCT1 in brain endothelial cells

(2011) David Dickens et al.   BIOCHEMICAL PHARMACOLOGY

Substrate recognition and translocation by polyspecific organic cation transporters

(2011) Hermann Koepsell   BIOLOGICAL CHEMISTRY

Genetically Polymorphic OCT1: Another Piece in the Puzzle of the Variable Pharmacokinetics and Pharmacodynamics of the Opioidergic Drug Tramadol

(2011) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Characterization of Human OCT1-Mediated Transport of DAPI as a Fluorescent Probe Substrate

(2011) Tomoya Yasujima et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

(2011) T. Minematsu et al.   MOLECULAR CANCER THERAPEUTICS

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Genetic Polymorphisms in Organic Cation Transporter 1 (OCT1) in Chinese and Japanese Populations Exhibit Altered Function

(2010) L. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Organic Cation Transporters Modulate the Uptake and Cytotoxicity of Picoplatin, a Third-Generation Platinum Analogue

(2010) Swati S. More et al.   MOLECULAR CANCER THERAPEUTICS

OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users

(2010) Matthijs L. Becker et al.   NEUROGENETICS

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice

(2010) Shuanglian Li et al.   PHARMACEUTICAL RESEARCH

Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron

(2010) M V Tzvetkov et al.   PHARMACOGENOMICS JOURNAL

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2

(2009) Naoko Kimura et al.   BIOCHEMICAL PHARMACOLOGY

Clinical Relevance of a Pharmacogenetic Approach Using Multiple Candidate Genes to Predict Response and Resistance to Imatinib Therapy in Chronic Myeloid Leukemia

(2009) D. H. Kim et al.   CLINICAL CANCER RESEARCH

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

In vitroevidence for the role of OATP and OCT uptake transporters in drug–drug interactions

(2009) Jürgen Kindla et al.   Expert Opinion on Drug Metabolism & Toxicology

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

(2009) Anne T. Nies et al.   HEPATOLOGY

Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells

(2009) Melanie Bayer et al.   NUCLEAR MEDICINE AND BIOLOGY

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

(2009) M L Becker et al.   PHARMACOGENOMICS JOURNAL

Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells

(2008) T. Minematsu et al.   DRUG METABOLISM AND DISPOSITION

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

(2008) X. Ming et al.   DRUG METABOLISM AND DISPOSITION

Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection

(2008) N. Jung et al.   DRUG METABOLISM AND DISPOSITION

Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1

(2008) Gustav Ahlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins

(2008) Kittipong Tachampa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES