Review
Biochemistry & Molecular Biology
Silvia Gonzalez-Martinez, Belen Perez-Mies, David Pizarro, Tamara Caniego-Casas, Javier Cortes, Jose Palacios
Summary: Metaplastic breast carcinoma (MBC) is a rare triple negative invasive cancer with poor prognosis. The resistance mechanisms of MBC may involve epithelial-mesenchymal transition (EMT) and immune response, distinguishing it from other types of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ioanna Akrida, Francesk Mulita, Kerasia-Maria Plachouri, Nikolaos Benetatos, Ioannis Maroulis, Helen Papadaki
Summary: This review summarizes the role of EMT in the pathogenesis of Metaplastic Breast Carcinoma (MBC) and Phyllodes tumors (PTs), and suggests several anti-EMT targeting strategies as promising therapeutic approaches for patients suffering from these aggressive neoplasms.
Article
Oncology
Emily R. McMullen, Stephanie L. Skala, Maria E. Gonzalez, Sabra Djomehri, Darshan Shimoga Chandrashekar, Sooryanarayana Varambally, Celina G. Kleer
Summary: The study found that cytoplasmic pEZH2 T367 is significantly upregulated in squamous subtypes compared to mesenchymal and spindle subtypes. The expression and subcellular localization of cytoplasmic pEZH2 T367 may be useful for distinguishing metaplastic carcinoma subtypes.
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Medicine, Research & Experimental
Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang, Xiangbo Xu
Summary: The study revealed that the overexpression of CHN1 is associated with lymph node metastasis and low survival rates in cervical carcinoma patients. CHN1 overexpression promoted cell proliferation, migration, and invasion by inducing EMT-related transcription factors. Furthermore, in vitro experiments showed that CHN1 overexpression activated the Akt/GSK-3 beta/Snail signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Horatio R. Thomas, Bonnie Hu, Baris Boyraz, Andrew Johnson, Veerle I. Bossuyt, Laura Spring, Rachel B. Jimenez
Summary: Metaplastic breast cancer (MpBC) is a rare aggressive malignancy with poor prognosis. The relationships between clinical and pathological features, treatment approach, and outcomes of MpBC remain underexplored. In this review article, existing data on MpBC regarding clinical, pathological and genomic features, management, and outcomes are synthesized, and potential targets for future clinical trials are identified.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Alex Mremi, Theresia Edward Mwakyembe, Mujaheed Suleman, Jay Lodhia
Summary: Metaplastic breast carcinomas are rare and matrix-producing subtypes have a better prognosis. Surgery and chemotherapy are the main treatments for this unique disease entity.
CLINICAL CASE REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Pathology
Agostina Stradella, Pablo Gargallo, Monica Cejuela, Anna Petit, Jan Bosch-Schips, Paula Carbonell, Sabela Recalde, Andrea Vethencourt, Adela Fernandez-Ortega, Catalina Falo, Miguel Gil-Gil, Silvia Vazquez, Veronica Obadia, Rafael Villanueva-Vazquez, Teresa Soler-Monso, Ines Calabria, Sonia Pernas
Summary: Metaplastic breast carcinomas are rare tumors with poor prognosis, characterized by high frequency of TP53 and TERT promoter mutations, as well as MYC amplifications. Relapse/progression samples are particularly enriched for MYC amplification.
Article
Environmental Sciences
Yan Wang, Siling Li, Jing Zhao, Qiuyue Li, Chunjie Xu, Huihui Wu, Zhonghui Zhu, Lin Tian
Summary: The study revealed that partial EMT may be involved in the development of pulmonary fibrosis diseases, with Snail playing a critical role in the process. The process of EMT in epithelial cells promoted the differentiation of lung myofibroblasts, and this epithelial-mesenchymal crosstalk was mainly controlled by Snail.
Article
Oncology
Clinton Yam, Nour Abuhadra, Ryan Sun, Beatriz E. Adrada, Qing-Qing Ding, Jason B. White, Elizabeth E. Ravenberg, Alyson R. Clayborn, Vicente Valero, Debu Tripathy, Senthilkumar Damodaran, Banu K. Arun, Jennifer K. Litton, Naoto T. Ueno, Rashmi K. Murthy, Bora Lim, Luis Baez, Xiaoxian Li, Aman U. Buzdar, Gabriel N. Hortobagyi, Alistair M. Thompson, Elizabeth A. Mittendori, Gaiane M. Rauch, Rosalind P. Candelaria, Lei Huo, Stacy L. Moulder, Jeffrey T. Chang
Summary: This study analyzed the clinical outcomes, survival status, and genomic profiles of patients with metaplastic breast cancer (MpBC) who received neoadjuvant therapy. The results showed that MpBC patients had a lower response rate to the therapy, shorter survival time, and distinct genetic characteristics compared to non-metaplastic triple-negative breast cancer (TNBC) patients. Furthermore, some non-MpTNBC patients exhibited similar gene expression profiles and treatment responses to MpBC.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Krithika Badarinath, Binita Dam, Sunny Kataria, Ravindra K. Zirmire, Rakesh Dey, Gaurav Kansagara, Johan Ajnabi, Akshay Hegde, Randhir Singh, Tafheem Masudi, Janani Sambath, Sasikala P. Sachithanandan, Prashant Kumar, Akash Gulyani, You-Wen He, Sudhir Krishna, Colin Jamora
Summary: In this study, the transcription factor Snail is found to play a role in maintaining the stemness of epidermal keratinocytes in cutaneous squamous cell carcinoma (cSCC) models through the secretion of Mindin protein and activation of the Src-STAT3 pathway. Disruption of this signaling module attenuates tumorigenesis in human cSCC.
Article
Dentistry, Oral Surgery & Medicine
Yue Du, Die Lv, Bomiao Cui, Xiaoying Li, Hongli Chen, Yingzhu Kang, Qianming Chen, Yun Feng, Ping Zhang, Jiao Chen, Xuedong Zhou
Summary: In this study, it was found that PKD1 is correlated with metastasis and poor prognosis in SACC patients. Inhibition of PKD1 attenuated proliferation, migration, invasion, and EMT of SACC cells, while kinase active PKD1 promoted cell migration. The mechanism involves PKD1 regulating Snail protein stability to impact SACC metastasis.
Article
Cell Biology
Yung-Wei Lin, Yu-Ching Wen, Chi-Hao Hsiao, Feng-Ru Lai, Shun-Fa Yang, Yi-Chieh Yang, Kuo-Hao Ho, Feng-Koo Hsieh, Michael Hsiao, Wei-Jiunn Lee, Ming-Hsien Chien
Summary: SPOCK1 is found to be upregulated in ccRCC tissues and is associated with advanced clinical stages and metastasis. Knockdown and overexpression of SPOCK1 in ccRCC cells affect cell clonogenic ability, migration/invasion ability, and tumor growth and invasion in vitro and in vivo. The mechanism involves the activation of the Snail/Slug-MMP-2 axis to promote EMT and cell motility.
Article
Chemistry, Physical
Kamran Hosseini, Palina Trus, Annika Frenzel, Carsten Werner, Elisabeth Fischer-Friedrich
Summary: The study reveals that EMT can change the mechanical properties of skin epithelial cells in a cell-cycle dependent manner. Additionally, EMT can boost cellular proliferation and result in changes in the actin cortex. These changes are primarily dependent on the transcription factor snail, which is upregulated during EMT.
