Article
Chemistry, Physical
M. Vadala, E. Kroell, M. Kueppers, D. C. Lupascu, R. Brunstermann
Summary: The development of biofuels and the quest for renewable energy sources are crucial issues due to the increasing scarcity of other resources. Hydrogen, known for its high energy capacity and clean attributes, has gained significant attention as a biofuel. Dark fermentation, a method that produces hydrogen from low-value organic waste and has minimal energy requirements, has emerged as an interesting approach in this regard. This article explores the potential of incorporating iron oxide particles into porous scaffolds, with the aim of enhancing hydrogen production through hosting mixed cultures of clostridia. The presence of various metal oxides can promote bacterial growth and stimulate the bioactivity of hydrogen-producing species, thus increasing bio-hydrogen production. The scaffolds analyzed in this study consist of polydimethylsiloxane (PDMS) containing Fe2O3 particles, and were fabricated using the sugar template method. X-ray diffraction patterns were employed to analyze the behavior and stability of these scaffolds in a dark fermentation environment.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Clinical Neurology
Qiao Zhang, Jinlin Chen, Jingjing Lin, Ruichao Liang, Min He, Yanchao Wang, Hong Tan
Summary: In this study, a three-dimensional biodegradable waterborne polyurethane scaffold was investigated as a tool to promote endogenous brain tissue regeneration after intracerebral hemorrhage (ICH). The results showed that the scaffold could attract immune cells and modulate their types and secretions to promote endogenous brain regeneration.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Engineering, Biomedical
Jiang Wu, Liwei Fu, Zineng Yan, Yu Yang, Han Yin, Pinxue Li, Xun Yuan, Zhengang Ding, Teng Kang, Zhuang Tian, Zhiyao Liao, Guangzhao Tian, Chao Ning, Yuguo Li, Xiang Sui, Mingxue Chen, Shuyun Liu, Quanyi Guo
Summary: In this study, a hierarchical porous ECM scaffold with GDF-5 was successfully fabricated using ECM as a bioink in LDM 3D printing. The 7% ECM scaffold showed the best biocompatibility and the addition of GDF-5 significantly improved BMSC migration and chondrogenic differentiation. In vivo results demonstrated that the ECM/GDF-5 scaffold enhanced in situ cartilage repair.
BIOMATERIALS RESEARCH
(2023)
Article
Engineering, Biomedical
Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang, Yong He
Summary: A new method for breast reconstruction was developed using a newly designed bionic ink and projection-based three-dimensional bioprinting. The porous prosthesis printed with this method showed good biocompatibility when implanted subcutaneously in nude mice, suggesting its potential as a promising breast reconstruction material when combined with pre-placed adipose tissues.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Engineering, Biomedical
Roseline Menezes, Lauren Sherman, Pranela Rameshwar, Treena Livingston Arinzeh
Summary: Cartilage tissue engineering aims to repair damaged tissue using scaffolds containing components of the native extracellular matrix (ECM). This study evaluated the chondrogenic differentiation of mesenchymal stem cells (MSCs) on fibrous scaffolds containing cellulose sulfate, which showed enhanced TGF-beta 3-induced MSC chondrogenic differentiation and potential for promoting cartilage tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Li Chen, Xiao Huang, Hong Chen, Dingsu Bao, Xudong Su, Li Wei, Ning Hu, Wei Huang, Zhou Xiang
Summary: In this study, the sequential combined application of DMOG and PTHrP was used to efficiently drive chondrogenic differentiation of BMSCs and prevent hypertrophy. PLGA microspheres were fabricated to support the delivery of these compounds, and then incorporated onto a PLLA scaffold to create a microsphere-based scaffold delivery system. The controlled release of DMOG and PTHrP in a 3D culture system effectively mimicked the hypoxic microenvironment and promoted chondrogenic differentiation, which was confirmed by the interaction between HIF-1 alpha and YAP. The constructs were able to maintain cartilage formation in vivo and show promise for cartilage regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Xiaotang He, Wen Li, Siyang Liu, Yi Li, Yining Chen, Nianhua Dan, Weihua Dan, Meifeng Zhu
Summary: In this study, high-strength, flexible, and porous collagen-based scaffolds were successfully prepared using a novel strategy. Compared to regular collagen scaffolds, these scaffolds demonstrated superior mechanical properties and cell compatibility. Animal experiments showed that the scaffolds promoted cell infiltration, vascularization, and tissue regeneration. This study provides a new solution for tissue repair and broadens the application range in regenerative medicine.
MATERIALS TODAY BIO
(2022)
Article
Biotechnology & Applied Microbiology
Claudio Intini, Tom Hodgkinson, Sarah M. Casey, John P. Gleeson, Fergal J. O'Brien
Summary: CI/II-HyA scaffolds were able to enhance and prolong cartilage repair while reducing hypertrophic cartilage formation, as evidenced by improved cartilage-like formation and consistent responses in protein expression analysis. The study also highlighted the variable chondrogenic abilities of human MSCs from different donors.
BIOENGINEERING-BASEL
(2022)
Article
Materials Science, Multidisciplinary
Hewei Zhao, Xianqin Xing, Gehui Zhang, Wenyu Liu, Haoyu Dong, Zhanjie Lu, Tianyuan Li, Junfeng Zhang, Zhihai Cheng, Le Wang, Shanshan Chen
Summary: In this study, a simple water-assisted technique was developed to directly remove the PMMA layer from the graphene surface. No organic solvents were used in the transfer process, resulting in a clean and intact graphene film. This method enables easy transfer of different types of graphene samples to diverse substrates, and the transferred graphene film exhibits high cleanliness and improved performance compared to conventional wet transfer technique.
Article
Polymer Science
Alda Malagon-Escandon, Mathieu Hautefeuille, Edgar Jimenez-Diaz, Jesus Arenas-Alatorre, Jose Manuel Saniger, Isidro Badillo-Ramirez, Nadia Vazquez, Gabriela Pinon-Zarate, Andres Castell-Rodriguez
Summary: The use of decellularized ECM material from bovine cancellous bone to obtain a three-dimensional porous scaffold has shown promising results for potential therapeutic strategies in bone repair. The scaffold retains osteoconductive and osteoinductive properties and exhibits osteogenic potential when seeded with human Wharton's jelly mesenchymal stromal cells (hWJ-MSCs).
Article
Chemistry, Multidisciplinary
Shanshan Qin, Gaozhi Ou, Biao Wang, Zheyu Li, Rui Hu, Ying Li, Yunhuang Yang
Summary: This study reports a photolithography-free method for rapid fabrication of PDMS devices. By using a laser cutter to ablate a tape, a male photoresist mold can be obtained within 5 minutes by a simple heating-step. The method offers advantages of low input, simple operation procedure, and short fabrication time.
CHINESE CHEMICAL LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Zhenjia Che, Yifu Sun, Wenbin Luo, Liwei Zhu, Youbin Li, Chenyi Zhu, Tengyue Liu, Lanfeng Huang
Summary: Repairing severe bone defects is a challenge in orthopedics. Three-dimensional printing technology is used to create advanced bone tissue engineering scaffolds for promoting bone regeneration. In addition to osteogenic induction, angiogenesis is crucial for bone reconstruction. Researchers constructed a 3D-printed composite titanium scaffold system loaded with a thermosensitive collagen hydrogel containing vascular endothelial growth factor and bone morphogenetic protein-9. The system showed good biocompatibility and promoted angiogenesis and osseointegration in vivo. This study provides a theoretical basis for developing bioactive implant interfaces for patients with osteogenic defects.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Sara C. Santos, Catarina A. Custodio, Joao F. Mano
Summary: This study introduces a novel human protein-derived porous scaffold produced from platelet lysates, which serves as a platform for xeno-free 3D cell culture. The results show that the scaffold has tunable morphology and mechanical properties, making it suitable for human cell culture without the need for animal-derived supplements.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Chang Lei, Yuxue Cao, Sepanta Hosseinpour, Fang Gao, Jingyu Liu, Jianye Fu, Reuben Staples, Saso Ivanovski, Chun Xu
Summary: This study demonstrates the fabrication of hydroxyapatite-dendritic mesoporous silica nanoparticles based scaffolds for bone regeneration, showing excellent biocompatibility and osteogenic potential both in vitro and in vivo. The hierarchical pore structure of the scaffolds provides a promising approach for bone tissue engineering.
Article
Materials Science, Biomaterials
Yanchao Wang, Jingjing Lin, Jinlin Chen, Ruichao Liang, Qiao Zhang, Jiehua Li, Min Shi, Lei Li, Xueling He, Ting Lan, Xuhui Hui, Hong Tan
Summary: Decellularized extracellular matrix (dECM) nerve guide conduits (NGCs) are a promising strategy for peripheral nerve system (PNS) injury treatment. This study developed polyurethane-based NGCs incorporating decellularized spinal cord (BWPU-DSC NGCs) to repair peripheral nerves. BWPU-DSC NGCs have mechanical properties similar to polyurethane NGCs and can promote peripheral nerve regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Monsur Islam, Ahsana Sadaf, Milagros Ramos Gomez, Dario Mager, Jan G. Korvink, Andres Diaz Lantada
Summary: Multi-scale 3D carbon architectures play a crucial role in tissue engineering by allowing three-dimensional cell colonization essential for tissue growth. The hybrid structures, made of carbon fiber and microlattice, show improved compressive strength and flexibility, making them promising for soft-tissue regeneration. Additionally, these structures facilitate three-dimensional cell colonization, indicating their potential for future tissue repair applications.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Physical
Maria Dolores Bermejillo Barrera, Francisco Franco-Martinez, Andres Diaz Lantada
Summary: Designing tissue engineering scaffolds with complex mechanical features can benefit from the application of artificial intelligence and machine learning methods. Using 3D convolutional neural networks to predict the mechanical properties of innovative scaffolds is an effective strategy. This approach has the potential for applications beyond tissue engineering in various fields.
Article
Education & Educational Research
Ignacio De los Rios-Carmenado, Susana Sastre-Merino, Andres Diaz Lantada, Javier Garcia-Martin, Priscila Nole, Jorge E. Perez-Martinez
Summary: Educational innovation governance plays a key role in improving universities globally, with mature governance leading to higher rankings and the promotion of innovative projects that contribute to strategic changes in teaching, research, and societal connections.
STUDIES IN EDUCATIONAL EVALUATION
(2021)
Article
Chemistry, Physical
William Solorzano-Requejo, Carlos Ojeda, Andres Diaz Lantada
Summary: The biomechanical performance of hip prostheses can be improved by using short stems, especially for younger patients. The combination of short stems with personalized design can help preserve bone stock, reduce stress shielding, and enhance the overall biomechanical performance of the implants. A novel design methodology for custom-made short femoral stems, utilizing elliptical adjustment for quasi-automated CAD modeling, has been proposed and validated in this study.
Review
Chemistry, Physical
Vladislav A. Lvov, Fedor S. Senatov, Alnis A. Veveris, Vitalina A. Skrybykina, Andres Diaz Lantada
Summary: Auxetic metamaterials with a negative Poisson ratio have the properties of lateral expansion when stretched and densification when compressed. Due to their similarity to biological tissues, auxetics have potential applications in the field of medicine. This research study provides a comprehensive overview of auxetic metamaterials in biomedical devices, including prosthetics, orthotics, ergonomic appliances, in vitro medical devices, and tissue engineering scaffolds.
Article
Multidisciplinary Sciences
Gonzalo Peralta Marino, Stefano De la Pierre, Milena Salvo, Andres Diaz Lantada, Monica Ferraris
Summary: This study explores the application of modelling and additive layer manufacturing (ALM) for creating materials with interlocking structures to reduce stress concentration in lap joints. The effectiveness of this approach is discussed through modelling and experimental validation, highlighting its potential as an alternative to traditional joining processes.
SCIENTIFIC REPORTS
(2022)
Review
Engineering, Biomedical
Monsur Islam, Andres Diaz Lantada, Dario Mager, Jan G. Korvink
Summary: Carbon materials have great potential in the healthcare field, especially in tissue repair and regeneration. Challenges remain in designing carbon-based cell niches and scaffolds. By studying the role of carbon materials in regenerative medicine and related manufacturing strategies, further applications of carbon materials can be promoted. Understanding fundamental breakthroughs and future research trends is also necessary.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Energy & Fuels
Mar Cogollo de Cadiz, Pedro Marti Balsalobre, Andres Diaz Lantada
Summary: This study investigates the characteristics of corona discharge in terms of air flow for a new proposed electrode configuration and geometry. The obtained voltage-current curves and flow-pressure curves provide design rules for the use of corona discharge as a silent air propeller and for sterilization purposes.
Article
Engineering, Manufacturing
Francisco Franco-Martinez, Christian Grasl, Erik Kornfellner, Matthias Vostatek, Adrian Martinez Cendrero, Francesco Moscato, Andres Diaz Lantada
Summary: Metamaterials and metasurfaces are engineered materials with special physical properties achieved through precise manufacturing techniques. The combination of these materials can result in textured designs with unexplored potential benefits and industrial applications.
VIRTUAL AND PHYSICAL PROTOTYPING
(2022)
Article
Engineering, Biomedical
Andres Diaz Lantada
Summary: This article highlights the significance of the 100th anniversary of the establishment of the school and manifesto of Bauhaus, emphasizing its potential to transform BME.
Article
Engineering, Biomedical
Andres Diaz Lantada
Summary: Since the emergence of 3D printing in the 1980s and 90s, the possibility of using additive manufacturing technologies to create highly complex and personalized medical devices has revolutionized the field. Traditional subtracting manufacturing methods and mass production chains are inadequate for emulating the intricate geometries and functional gradients of the human body, making 3D printing a game changer in the development of medical devices.
Article
Engineering, Biomedical
Andres Diaz Lantada, Carmelo De Maria
Summary: Additive manufacturing technologies, especially 3D printers and bioprinters, promote sustainability by processing waste materials and creating value. In healthcare, personalized biomedical devices manufactured with sustainable materials contribute to solving supply chain issues and driving economic growth.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Andres Diaz Lantada
Summary: The German language is renowned for its ability to express complex ideas and transformative processes in a single word. The term "Biologiesierung" in German refers to the integration of natural principles and biological systems into a field of study. It is often translated in English as the "biologization" of a specific field, where the principles of nature are incorporated. The verb "biologize" may be a better way to describe the action, with "biologizing X" referring to the process and "biologized X" to the result. I am using these terms here for conciseness.
Article
Engineering, Biomedical
Andres Diaz Lantada
Summary: Important lessons can be learned from the ongoing COVID-19 pandemic, such as the need for global collaboration in addressing health concerns, the necessity of sustainable and equitable innovations in the biomedical industry, and the threat of unethical behaviors to achieving the Sustainable Development Goals.
Article
Education, Scientific Disciplines
Andres Diaz Lantada, Jose L. Martin Nunez
Summary: The training and professional development of engineering educators are crucial for universities to serve society, and the main challenges for promoting well-trained and change-oriented engineering educators involve teachers themselves and their teaching methodologies, students and relationships with educators, available resources, and the surrounding environment.
INTERNATIONAL JOURNAL OF ENGINEERING EDUCATION
(2021)
