Novel roles of the CCR4-NOT complex

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression

(2014) D. Bhandari et al.   GENES & DEVELOPMENT

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

The Not4 E3 Ligase and CCR4 Deadenylase Play Distinct Roles in Protein Quality Control

(2014) David Halter et al.   PLoS One

The fate of the messenger is pre-determined: A new model for regulation of gene expression

(2013) Gal Haimovich et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes

(2013) Elmar Wahle et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA decay mechanisms: Specificity through diversity

(2013) Georg Stoecklin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Intracellular ribonucleases involved in transcript processing and decay: Precision tools for RNA

(2013) Cecília Maria Arraiano et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1

(2013) Clément Chapat et al.   EMBO JOURNAL

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

(2013) Latifa Zekri et al.   EMBO JOURNAL

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)

(2013) Monika Hämmerle et al.   HEPATOLOGY

Role of Sam68 in Post-Transcriptional Gene Regulation

(2013) Flora Sánchez-Jiménez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure and assembly of the NOT module of the human CCR4–NOT complex

(2013) Andreas Boland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and RNA-binding properties of the Not1–Not2–Not5 module of the yeast Ccr4–Not complex

(2013) Varun Bhaskar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing

(2013) A. Kamenska et al.   NUCLEIC ACIDS RESEARCH

Effects of the Yeast RNA-Binding Protein Whi3 on the Half-Life and Abundance of CLN3 mRNA and Other Targets

(2013) Ying Cai et al.   PLoS One

C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex

(2013) Fabienne Mauxion et al.   RNA Biology

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

(2013) Praveen Bawankar et al.   RNA Biology

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

Specificity factors in cytoplasmic polyadenylation

(2013) Amanda Charlesworth et al.   Wiley Interdisciplinary Reviews-RNA

The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal

(2013) Willy Joly et al.   Stem Cell Reports

The control of elongation by the yeast Ccr4–Not complex

(2012) Joseph C. Reese   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The eukaryotic transcriptional machinery regulates mRNA translation and decay in the cytoplasm

(2012) Nili Dahan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ccr4-Not complex: the control freak of eukaryotic cells

(2012) Jason E. Miller et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation

(2012) M. Sun et al.   GENOME RESEARCH

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

(2012) Jamie Van Etten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

(2012) Jérôme Basquin et al.   MOLECULAR CELL

Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase

(2012) Olesya O. Panasenko et al.   MOLECULAR MICROBIOLOGY

Surveillance pathways rescuing eukaryotic ribosomes lost in translation

(2012) Marc Graille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translational control by changes in poly(A) tail length: recycling mRNAs

(2012) Laure Weill et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

Interaction between NANOS2 and the CCR4-NOT Deadenylation Complex Is Essential for Male Germ Cell Development in Mouse

(2012) Atsushi Suzuki et al.   PLoS One

Cnot1, Cnot2, and Cnot3 Maintain Mouse and Human ESC Identity and Inhibit Extraembryonic Differentiation

(2012) Xiaofeng Zheng et al.   STEM CELLS

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

(2012) C. J. Decker et al.   Cold Spring Harbor Perspectives in Biology

CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance

(2012) Giulia Venturini et al.   PLoS Genetics

Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1

(2011) Jian Lei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

(2011) Tatjana Trcek et al.   CELL

A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation

(2011) Petra Paul et al.   CELL

Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase

(2011) Nao Hosoda et al.   EMBO JOURNAL

Obesity resistance and increased hepatic expression of catabolism-related mRNAs inCnot3+/−mice

(2011) Masahiro Morita et al.   EMBO JOURNAL

Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells

(2011) Juha Grönholm et al.   FASEB JOURNAL

Insights into the structure of the CCR4-NOT complex by electron microscopy

(2011) Fariborz Nasertorabi et al.   FEBS LETTERS

The role of tristetraprolin in cancer and inflammation

(2011) Sandhya Sanduja   Frontiers in Bioscience-Landmark

The Ccr4–Not complex

(2011) Martine A. Collart et al.   GENE

The multifunctional Ccr4–Not complex directly promotes transcription elongation

(2011) Jennifer A. Kruk et al.   GENES & DEVELOPMENT

CUP promotes deadenylation and inhibits decapping of mRNA targets

(2011) C. Igreja et al.   GENES & DEVELOPMENT

Not4 E3 Ligase Contributes to Proteasome Assembly and Functional Integrity in Part through Ecm29

(2011) O. O. Panasenko et al.   MOLECULAR AND CELLULAR BIOLOGY

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

(2011) Michal Rabani et al.   NATURE BIOTECHNOLOGY

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

The Ccr4-Not Complex Interacts with the mRNA Export Machinery

(2011) Shana C. Kerr et al.   PLoS One

Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae

(2011) J. Assenholt et al.   RNA

Coupled Evolution of Transcription and mRNA Degradation

(2011) Mally Dori-Bachash et al.   PLOS BIOLOGY

The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

(2011) Kentaro Ito et al.   Protein & Cell

RNA Polymerase II Subunits Link Transcription and mRNA Decay to Translation

(2010) Liat Harel-Sharvit et al.   CELL

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function

(2010) G. Gregory Neely et al.   CELL

Translational Repression by Deadenylases

(2010) Amy Cooke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors

(2010) Y.-C. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment

(2010) S. L. Clement et al.   MOLECULAR AND CELLULAR BIOLOGY

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

(2010) Christel Rouget et al.   NATURE

Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

(2010) Isabel Novoa et al.   NATURE CELL BIOLOGY

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

(2010) Felix Tritschler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of Not4p Functions Parallel to BUR2 to Regulate Resistance to Cellular Stresses in Saccharomyces cerevisiae

(2010) Nga-Chi Lau et al.   PLoS One

NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs

(2010) Atsushi Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How and where are nonsense mRNAs degraded in mammalian cells?

(2010) Oliver Mühlemann et al.   RNA Biology

Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation

(2010) C. Temme et al.   RNA

The structural basis for deadenylation by the CCR4-NOT complex

(2010) Mark Bartlam et al.   Protein & Cell

Mechanisms of deadenylation-dependent decay

(2010) Chyi-Ying A. Chen et al.   Wiley Interdisciplinary Reviews-RNA

Human Ccr4–Not complexes contain variable deadenylase subunits

(2009) Nga-Chi Lau et al.   BIOCHEMICAL JOURNAL

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide-associated complex Egd2 under stress conditions

(2009) Hiroyuki Hiraishi et al.   FEBS Journal

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal

(2009) G. Hu et al.   GENES & DEVELOPMENT

Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression

(2009) D. P. Mersman et al.   GENES & DEVELOPMENT

Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein Degradation by the Proteasome

(2009) Lyudmila N. Dimitrova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation

(2009) Akhmed Aslam et al.   MOLECULAR BIOLOGY OF THE CELL

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

(2009) Shengli Hao et al.   NATURE IMMUNOLOGY

The CCR4-NOT Complex Physically and Functionally Interacts with TRAMP and the Nuclear Exosome

(2009) Nowel Azzouz et al.   PLoS One

Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair

(2009) Hélène Gaillard et al.   PLoS Genetics

Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes

(2008) V. Goler-Baron et al.   GENES & DEVELOPMENT

Ribosome Association and Stability of the Nascent Polypeptide-Associated Complex Is Dependent Upon Its Own Ubiquitination

(2008) O. O. Panasenko et al.   GENETICS

Components of the CCR4-NOT Complex Function as Nuclear Hormone Receptor Coactivators via Association with the NRC-interacting Factor NIF-1

(2008) Shivani Garapaty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

(2008) Dinghai Zheng et al.   JOURNAL OF CELL BIOLOGY

Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation

(2008) Ophir Shalem et al.   Molecular Systems Biology

A deadenylation negative feedback mechanism governs meiotic metaphase arrest

(2008) Eulàlia Belloc et al.   NATURE

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells

(2008) Angela Schwede et al.   NUCLEIC ACIDS RESEARCH