Epigenetics and the Environment: In Search of the “Toleroasome” Vital to Execution of Ischemic Preconditioning

Memories from the Polycomb Group Proteins

(2012) Chiara Lanzuolo et al.   Annual Review of Genetics

Painted Turtle Cortex is Resistant to an in Vitro Mimic of the Ischemic Mammalian Penumbra

(2012) Matthew Edward Pamenter et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?

(2012) Saravanan S Karuppagounder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial sirtuins: regulators of protein acylation and metabolism

(2012) Wenjuan He et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain

(2012) Santosh Ramamurthy et al.   Experimental Neurobiology

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

(2011) Kahlilia C Morris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Histone Deacetylase Inhibitors Preserve White Matter Structure and Function during Ischemia by Conserving ATP and Reducing Excitotoxicity

(2011) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

Multiple Preconditioning Paradigms Converge on Interferon Regulatory Factor-Dependent Signaling to Promote Tolerance to Ischemic Brain Injury

(2011) S. L. Stevens et al.   JOURNAL OF NEUROSCIENCE

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

(2011) Yang-ja Lee et al.   PLoS One

Can Genes Modify Stroke Outcome and By What Mechanisms?

(2011) Roger P. Simon et al.   STROKE

Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia

(2011) Selva Baltan et al.   Translational Stroke Research

Small Molecule Activation of Adaptive Gene Expression

(2010) Rajiv R. Ratan et al.   Annals of the New York Academy of Sciences

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

(2010) Nima Mosammaparast et al.   Annual Review of Biochemistry

The Emerging Role of Epigenetics in Stroke

(2010) Irfan A. Qureshi et al.   ARCHIVES OF NEUROLOGY

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

(2010) Stephen J. McConoughey et al.   EMBO Molecular Medicine

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

(2010) M. Stapels et al.   Science Signaling

New Endogenous Regulators of Class I Histone Deacetylases

(2010) A. Riccio   Science Signaling

Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb

(2010) R. S. Zukin   Science Signaling

Cyclooxygenase-2 Mediates Hyperbaric Oxygen Preconditioning in the Rat Model of Transient Global Cerebral Ischemia

(2010) Oumei Cheng et al.   STROKE

Remote Limb Ischemic Postconditioning Protects Against Neonatal Hypoxic–Ischemic Brain Injury in Rat Pups by the Opioid Receptor/Akt Pathway

(2010) Yilin Zhou et al.   STROKE

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions

(2009) Sama F Sleiman et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

SUMOylation participates in induction of ischemic tolerance

(2009) Yang ja Lee et al.   JOURNAL OF NEUROCHEMISTRY

Histone Deacetylase Inhibitors Prevent p53-Dependent and p53-Independent Bax-Mediated Neuronal Apoptosis through Two Distinct Mechanisms

(2009) T. Uo et al.   JOURNAL OF NEUROSCIENCE

Epigenetics and the nervous system: epiphenomenon or missing piece of the neurotherapeutic puzzle?

(2009) Rajiv R Ratan   LANCET NEUROLOGY

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

(2009) Jin Young Kim et al.   NATURE NEUROSCIENCE

Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia

(2009) Emil Zeynalov et al.   NEUROBIOLOGY OF DISEASE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Resveratrol and Ischemic Preconditioning in the Brain

(2008) Ami Raval et al.   CURRENT MEDICINAL CHEMISTRY

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury

(2007) Ferah Yildirim et al.   EXPERIMENTAL NEUROLOGY