Hyperphosphorylation of tau by GSK-3β in Alzheimer’s disease: The interaction of Aβ and sphingolipid mediators as a therapeutic target

Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer’s disease

(2013) Min-Young Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease

(2013) Hirosha Geekiyanage et al.   NEUROBIOLOGY OF AGING

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer’s disease?

(2012) Michelle M Mielke et al.   Clinical Lipidology

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

(2012) Xiangnan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Human fetal tau protein isoform: Possibilities for Alzheimer's disease treatment

(2012) Nataša Jovanov-Milošević et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Soluble A  Promotes Wild-Type Tau Pathology In Vivo

(2012) M. A. Chabrier et al.   JOURNAL OF NEUROSCIENCE

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-  Precursor Protein

(2012) C. Parr et al.   MOLECULAR AND CELLULAR BIOLOGY

Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases

(2012) Li Liu et al.   NEUROBIOLOGY OF AGING

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

(2012) M. Kosicek et al.   NEUROSCIENCE LETTERS

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

(2012) Kanae Iijima-Ando et al.   PLoS Genetics

Prophylactic lithium alleviates postoperative cognition impairment by phosphorylating hippocampal glycogen synthase kinase-3β (Ser9) in aged rats

(2011) LongDe Zhao et al.   EXPERIMENTAL GERONTOLOGY

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

(2011) Tomohiro Onishi et al.   JOURNAL OF NEUROCHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α

(2011) Brian M. Barth et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chain length-specific properties of ceramides

(2011) Sabine Grösch et al.   PROGRESS IN LIPID RESEARCH

The role of APP proteolytic processing in lipid metabolism

(2011) Marcus O. W. Grimm et al.   EXPERIMENTAL BRAIN RESEARCH

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

(2010) Norman J. Haughey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The γ-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer’s Disease

(2010) Annamaria Lanzillotta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Fibrillar Amyloid- -Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease

(2010) A. Jana et al.   JOURNAL OF NEUROSCIENCE

Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons

(2010) Zhaoxu Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

(2010) Maria Jose Metcalfe et al.   MOUNT SINAI JOURNAL OF MEDICINE

Alterations of the Sphingolipid Pathway in Alzheimer’s Disease: New Biomarkers and Treatment Targets?

(2010) Michelle M. Mielke et al.   NEUROMOLECULAR MEDICINE

The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases

(2010) Oshrit Ben-David et al.   NEUROMOLECULAR MEDICINE

Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments

(2010) Stephanie J. Adams et al.   PLoS One

Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death

(2009) Arundhati Jana et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Does Alzheimer's disease begin in the brainstem?

(2009) G. Simic et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fats, cerebrovasculature integrity and Alzheimer’s disease risk

(2009) R. Takechi et al.   PROGRESS IN LIPID RESEARCH

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

(2008) Ann C. McKee et al.   BRAIN RESEARCH

Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A

(2008) Ludovic Martin et al.   BRAIN RESEARCH

Tau isoform expression and regulation in human cortical neurons

(2008) Atul Deshpande et al.   FASEB JOURNAL

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

(2008) Archana Mukhopadhyay et al.   FASEB JOURNAL

Up-and-down topological mode of amyloid β-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters

(2008) Maho Utsumi et al.   GLYCOCONJUGATE JOURNAL

ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylation

(2008) Rosa Resende et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING