PTEN: A molecular target for neurodegenerative disorders

PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex

(2012) Q. Xiong et al.   JOURNAL OF NEUROSCIENCE

Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation

(2012) Marco Leibinger et al.   NEUROBIOLOGY OF DISEASE

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Janine Kirby et al.   BRAIN

Akt as a Victim, Villain and Potential Hero in Parkinson’s Disease Pathophysiology and Treatment

(2011) Lloyd A. Greene et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

(2011) Eunjin Lim et al.   EXPERIMENTAL NEUROLOGY

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models

(2011) Andrii Domanskyi et al.   FASEB JOURNAL

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Role of 17β-estradiol and testosterone in apoptosis

(2011) Andrea Vasconsuelo et al.   STEROIDS

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons

(2010) Ke Ning et al.   HUMAN MOLECULAR GENETICS

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

(2010) Young-Don Kwak et al.   Molecular Neurodegeneration

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

(2010) Yuma Sonoda et al.   NEUROSCIENCE LETTERS

Preservation of GABA A Receptor Function by PTEN Inhibition Protects Against Neuronal Death in Ischemic Stroke

(2010) Baosong Liu et al.   STROKE

Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-γ

(2009) Joshua A. Smith et al.   BRAIN RESEARCH

Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration

(2009) J. Simon Lunn et al.   Developmental Neurobiology

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+Channels

(2009) Ke Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability

(2009) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

Selective Deletion of PTEN in Dopamine Neurons Leads to Trophic Effects and Adaptation of Striatal Medium Spiny Projecting Neurons

(2009) Oscar Diaz-Ruiz et al.   PLoS One

Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase

(2008) Laia Tolosa et al.   JOURNAL OF NEUROCHEMISTRY

Vascular endothelial growth factor protects motoneurons from serum deprivation–induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition

(2008) L. Tolosa et al.   NEUROSCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

(2007) M.M. Fraser et al.   NEUROSCIENCE