Akt as a Victim, Villain and Potential Hero in Parkinson’s Disease Pathophysiology and Treatment

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Metastasis and AKT activation

(2011) Meng Qiao et al.   CELL CYCLE

Targeting mTOR with rapamycin: One dose does not fit all

(2011) David A. Foster et al.   CELL CYCLE

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

(2011) Bobby Thomas et al.   PLoS One

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells

(2010) Yoshikazu Tasaki et al.   BRAIN RESEARCH

Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection

(2010) Alexander Harkavyi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Use of growth factors for the treatment of Parkinson’s disease

(2010) Toru Yasuda et al.   Expert Review of Neurotherapeutics

Protein-tyrosine Phosphatase SHP2 Contributes to GDNF Neurotrophic Activity through Direct Binding to Phospho-Tyr687in the RET Receptor Tyrosine Kinase

(2010) Maurice Perrinjaquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A neuroprotective role for angiogenin in models of Parkinson’s disease

(2010) Trent U. Steidinger et al.   JOURNAL OF NEUROCHEMISTRY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease

(2010) J. Laganiere et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains

(2010) Raymond T. Bartus et al.   MOVEMENT DISORDERS

Low Dosage of Rasagiline and Epigallocatechin Gallate Synergistically Restored the Nigrostriatal Axis in MPTP-Induced Parkinsonism

(2010) Lydia Reznichenko et al.   Neurodegenerative Diseases

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway

(2010) H. Aleyasin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

(2010) Orly Weinreb et al.   PROGRESS IN NEUROBIOLOGY

α-Synuclein and dopamine at the crossroads of Parkinson's disease

(2010) Lara Lourenço Venda et al.   TRENDS IN NEUROSCIENCES

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

Rescue of α-synuclein cytotoxicity by insulin-like growth factors

(2009) Shyan-Yuan Kao   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Scientific rationale for the development of gene therapy strategies for Parkinson's disease

(2009) Tomas Björklund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Involvement of Akt in neurite outgrowth

(2009) Danielle E. Read et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gene Therapy for Neurological Disorders: Challenges and Future Prospects for the Use of Growth Factors for the Treatment of Parkinsons Disease

(2009) Fredric Manfredsson et al.   CURRENT GENE THERAPY

Endoplasmic Reticulum Protein Quality Control in Neurodegenerative Disease: The Good, the Bad and the Therapy

(2009) Wiep Scheper et al.   CURRENT MEDICINAL CHEMISTRY

Current Perspectives on Akt Akt-ivation and Akt-ions

(2009) Ronald W. Matheny et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Noncanonical Activation of Akt/Protein Kinase B in β-Cells by the Incretin Hormone Glucose-dependent Insulinotropic Polypeptide

(2009) Scott B. Widenmaier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

(2009) Sehee Kim et al.   JOURNAL OF ENDOCRINOLOGY

Regulation of the postnatal development of dopamine neurons of the substantia nigrain vivoby Akt/protein kinase B

(2009) Vincent Ries et al.   JOURNAL OF NEUROCHEMISTRY

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively

(2009) M.H. Grider et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

(2009) Kristen A Malkus et al.   Molecular Neurodegeneration

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

(2009) R. Kimura et al.   NEUROSCIENCE

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

A pro-drug of the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine

(2009) Jianfei Chao et al.   NEUROSCIENCE LETTERS

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys

(2009) Marc Morissette et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease

(2008) Arnulfo Quesada et al.   Developmental Neurobiology

Akt as a therapeutic target in cancer

(2008) Linda S Steelman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine

(2008) Jezabel Rodriguez-Blanco et al.   JOURNAL OF NEUROCHEMISTRY

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease

(2008) Alexander Harkavyi et al.   Journal of Neuroinflammation

Association between AKT1 gene and Parkinson's disease: A protective haplotype

(2008) Georgia Xiromerisiou et al.   NEUROSCIENCE LETTERS

Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

(2008) Mehmet Cansev et al.   NEUROSCIENCE RESEARCH

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE

Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson’s disease

(2007) M. Bousquet et al.   FASEB JOURNAL

Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells

(2007) Kazuhiro Nakaso et al.   NEUROSCIENCE LETTERS