Article
Genetics & Heredity
Ainur Seisenova, Asset Daniyarov, Askhat Molkenov, Aigul Sharip, Andrei Zinovyev, Ulykbek Kairov
Summary: The study utilized ICA to analyze publicly available esophageal cancer data to identify and comprehensively analyze reproducible signaling pathways and molecular signatures in this cancer type. The results may uncover potential biomarkers of esophageal carcinogenesis and help predict early tumor development.
FRONTIERS IN GENETICS
(2021)
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Shahab Alizadeh, Zahra Bagheri-Hosseinabadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Curcumin supplementation has been shown to significantly reduce CRP and hs-CRP levels, with a stronger effect observed at doses <= 1,000 mg/day and interventions lasting <= 10 weeks. A non-linear reduction in hs-CRP was seen with curcumin consumption, especially at doses below 2,000 mg/day. Overall, curcumin appears beneficial in decreasing inflammatory markers such as hs-CRP and CRP.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Kechong Zhou, Chao Li, Tao Chen, Xuejun Zhang, Baoluo Ma
Summary: In this meta-analysis of 16 studies, elevated levels of C-reactive protein (CRP) were found to be associated with worse overall survival, cancer-specific survival, and progression-free survival in patients with prostate cancer. Subgroup analysis based on disease staging yielded consistent results. However, further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Saeed Aslani, Danyal Imani, Bahman Razi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: This meta-analysis demonstrates that resveratrol consumption is effective in lowering CRP and hs-CRP levels in inflammatory conditions, especially if supplementation takes place for >= 10 weeks with >= 500 mg/day.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Guocan Yu, Wenfeng Yu, Xudong Xu, Bo Ye, Liwei Yao
Summary: This study aims to evaluate the efficacy and safety of immunotherapy for resectable esophageal cancer as neoadjuvant treatment, providing reliable evidence for clinicians and patients to formulate the best pre-surgical treatment plan.
Review
Multidisciplinary Sciences
Harman Sharma, Sandhli Sharma, Anirudh Krishnan, Daniel Yuan, Venkat N. Vangaveti, Usman H. Malabu, Nagaraja Haleagrahara
Summary: The diagnostic test accuracy of inflammatory markers, including CRP and PCT, in identifying and differentiating the severity of DFU has been explored in this systematic review. CRP was found to be the best marker for diagnosing grade 2 DFU, while PCT was the best marker for diagnosing grade 3 DFU. Further research is needed to establish standardized cutoff values for these markers in diagnosing diabetic foot ulcers.
Article
Surgery
Yajie Zhang, Dong Dong, Yuqin Cao, Maosheng Huang, Jian Li, Jiahao Zhang, Jules Lin, Inderpal S. Sarkaria, Lerut Toni, Rice David, Jie He, Hecheng Li
Summary: This article provides a comprehensive review of the literature comparing perioperative outcomes and long-term survival between robotic-assisted minimally invasive esophagectomy (RAMIE) and minimally invasive esophagectomy (MIE) for esophageal cancer. The results suggest that RAMIE is comparable to MIE in perioperative outcomes, but may have advantages in lymph node dissection in the abdominal cavity, lymph nodes dissected along the left recurrent laryngeal nerve, and 3-year disease-free survival.
Review
Oncology
Amin Doosti-Irani, Mohammad Ali Mansournia, Zahra Cheraghi, Abbas Rahimi-Foroushani, Peiman Haddad, Kourosh Holakouie-Naieni
Summary: The ultraflex stent, irradiation stent, and thermal ablative therapy were found to be the top ranking treatments in networks A, B, and C, respectively, based on the results of this network meta-analysis.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Genetics & Heredity
Jiayun Guan, Xixin Pan, Shenghang Ruan, Xiaopeng He, Yuhao Xu, Xiaoxiang Rong, Yanhua Ou
Summary: This meta-analysis investigated the association between irregular diet and the risk of esophageal cancer. The results showed that irregular diet increases the risk of esophageal cancer.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
You-Feng Zhou, Yan Huang, Guang-Hua Liu
Summary: This meta-analysis evaluated the effect of levetiracetam on serum C-reactive protein (CRP) in children with epilepsy. The results showed that serum CRP levels were significantly higher in children with epilepsy compared to healthy controls, and they were reduced by the treatment of levetiracetam.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Hui Luo, Hong Ge
Summary: This meta-analysis suggests that drinking hot tea is significantly associated with an increased risk of esophageal squamous cell carcinoma (ESCC), but not with esophageal adenocarcinoma (EAC).
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Fatemeh Hajizadeh-Sharafabad, Elham Sharifi Zahabi, Mahsa Malekahmadi, Rasoul Zarrin, Mohammad Alizadeh
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials to investigate the effects of carotenoids on inflammatory parameters. The results showed significant effects of carotenoids on C-reactive protein and interleukin-6, but not on tumor necrosis factor-alpha. Individual carotenoids like astaxanthin, lutein/zeaxanthin, and beta-cryptoxanthin significantly decreased CRP levels, while only lycopene led to a significant decrease in IL-6. Overall, carotenoids may have protective effects on inflammatory biomarkers.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Oncology
Meng Yuan, Yongxing Bao, Zeliang Ma, Yu Men, Yang Wang, Zhouguang Hui
Summary: This study conducted a network meta-analysis on different treatments for resectable esophageal cancer, finding that neoadjuvant chemoradiotherapy followed by surgery significantly improved overall survival and is the optimal treatment for patients. Future research should focus on optimizing neoadjuvant chemoradiotherapy regimens.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Jinjia Zhang, Huadong Wu, Rongying Wang
Summary: This meta-analysis indicates a relationship between metabolic syndrome and esophageal adenocarcinoma (EAC), with hyperglycemia, hypertension, and obesity potentially playing key roles among the individual components of metabolic syndrome.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Pharmacology & Pharmacy
Shiv Sharma, Swathi Sridhar, Alasdair McIntosh, Claudia-Martina Messow, Eva Munoz Aguilera, Rita Del Pinto, Davide Pietropaoli, Renata Gorska, Mateusz Siedlinski, Pasquale Maffia, Maciej Tomaszewski, Tomasz J. Guzik, Francesco D'Aiuto, Marta Czesnikiewicz-Guzik
Summary: The study compared the effects of intensive periodontal treatment and conventional periodontal treatment on arterial blood pressure, endothelial function, and inflammatory/metabolic biomarkers. The results showed that intensive periodontal treatment improved cardiovascular health in hypertensive and prehypertensive individuals, with no significant effect observed in normotensive individuals.
PHARMACOLOGICAL RESEARCH
(2021)
