Protein-Bound Uremic Toxins: New Culprits of Cardiovascular Events in Chronic Kidney Disease Patients

Long-Term Effects of the Oral Adsorbent, AST-120, in Patients with Chronic Renal Failure

(2013) K Maeda et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease

(2013) Shunsuke Ito et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall

(2013) A. Pletinck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

(2013) Hiroshi Watanabe et al.   KIDNEY INTERNATIONAL

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

Does P-Cresylglucuronide Have the Same Impact on Mortality as Other Protein-Bound Uremic Toxins?

(2013) Sophie Liabeuf et al.   PLoS One

The Uremic Toxin Indoxyl Sulphate Enhances Macrophage Response to LPS

(2013) Simona Adesso et al.   PLoS One

Indoxyl 3-sulfate stimulates Th17 differentiation enhancing phosphorylation of c-Src and STAT3 to worsen experimental autoimmune encephalomyelitis

(2013) Sung-Jun Hwang et al.   TOXICOLOGY LETTERS

Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma

(2013) You-Jung Hwang et al.   TOXICOLOGY LETTERS

Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production

(2012) Yoshiharu Itoh et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Activation of Aryl Hydrocarbon Receptor Mediates Indoxyl Sulfate-Induced Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells

(2012) Ippei Watanabe et al.   CIRCULATION JOURNAL

Cardiorenal Syndrome

(2012) Suree Lekawanvijit et al.   CIRCULATION RESEARCH

Normal and Pathologic Concentrations of Uremic Toxins

(2012) F. Duranton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Indoxyl Sulfate Induces Epithelial-to-Mesenchymal Transition in Rat Kidneys and Human Proximal Tubular Cells

(2011) Dilinaer Bolati et al.   AMERICAN JOURNAL OF NEPHROLOGY

Clopidogrel Effectively Suppresses Endothelial Microparticle Generation Induced by Indoxyl Sulfate via Inhibition of the p38 Mitogen-Activated Protein Kinase Pathway

(2011) Jung-Hwa Ryu et al.   BLOOD PURIFICATION

Effects of indoxyl sulfate on adherens junctions of endothelial cells and the underlying signaling mechanism

(2011) Yu-Sen Peng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An Update on Protein-Bound Uremic Retention Solutes

(2011) Raymond Vanholder et al.   JOURNAL OF RENAL NUTRITION

AST-120 Ameliorates Epithelial-to-Mesenchymal Transition and Interstitial Fibrosis in the Kidneys of Chronic Kidney Disease Rats

(2011) Dilinaer Bolati et al.   JOURNAL OF RENAL NUTRITION

Indoxyl Sulfate Induces Endothelial Cell Senescence by Increasing Reactive Oxygen Species Production and p53 Activity

(2011) Yelixiati Adelibieke et al.   JOURNAL OF RENAL NUTRITION

Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice

(2011) Suguru Yamamoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Novel method for simultaneous determination of p-cresylsulphate and p-cresylglucuronide: clinical data and pathophysiological implications

(2011) N. Meert et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of Oxidative Stress and Indoxyl Sulfate in Progression of Cardiovascular Disease in Chronic Kidney Disease

(2011) Hideki Fujii et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Protein-Bound Uremic Toxins: New Insight from Clinical Studies

(2011) Sophie Liabeuf et al.   Toxins

Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation

(2010) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

(2010) B. K. I. Meijers et al.   Clinical Journal of the American Society of Nephrology

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Indoxyl Sulfate Induces Leukocyte-Endothelial Interactions through Up-regulation of E-selectin

(2010) Shunsuke Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation

(2010) Tsukasa Nakamura et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Spherical Carbon Adsorbent (AST-120) Protects Deterioration of Renal Function in Chronic Kidney Disease Rats through Inhibition of Reactive Oxygen Species Production from Mitochondria and Reduction of Serum Lipid Peroxidation

(2010) Shigeru Owada et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

The Uremic Retention Solute p-Cresyl Sulfate and Markers of Endothelial Damage

(2009) Björn K.I. Meijers et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of a Carbonaceous Oral Adsorbent on the Progression of CKD: A Multicenter, Randomized, Controlled Trial

(2009) Tadao Akizawa et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Increasing Dialyzer Mass Transfer Area Coefficient and Dialysate Flow on Clearance of Protein-Bound Solutes: A Pilot Crossover Trial

(2009) Frank J.-G. Luo et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

ROS and PDFG-β receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration

(2009) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy

(2009) Tamehachi Namikoshi et al.   HYPERTENSION RESEARCH

Indoxyl Sulfate Promotes Proliferation of Human Aortic Smooth Muscle Cells by Inducing Oxidative Stress

(2009) Gulinuer Muteliefu et al.   JOURNAL OF RENAL NUTRITION

Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress

(2009) H. Fujii et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells

(2009) G. Muteliefu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of a Very Low-Protein Diet on Outcomes: Long-term Follow-up of the Modification of Diet in Renal Disease (MDRD) Study

(2008) Vandana Menon et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

AST-120 (Kremezin®) initiated in early stage chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects

(2008) Kazunori Konishi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Cardiorenal Syndrome

(2008) Claudio Ronco et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Free p-cresol is associated with cardiovascular disease in hemodialysis patients

(2008) B.K.I. Meijers et al.   KIDNEY INTERNATIONAL

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

(2008) A. Adijiang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanisms of Vascular Calcification in Chronic Kidney Disease

(2007) S. M. Moe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY