Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment

Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study

(2012) J. E. Levine et al.   BLOOD

Antigen-presenting cell–derived complement modulates graft-versus-host disease

(2012) Wing-Hong Kwan et al.   JOURNAL OF CLINICAL INVESTIGATION

Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction

(2012) H. Li et al.   JOURNAL OF IMMUNOLOGY

CD8+ Foxp3+ Regulatory T Cells Are Induced during Graft-versus-Host Disease and Mitigate Disease Severity

(2012) A. J. Beres et al.   JOURNAL OF IMMUNOLOGY

Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

(2012) Ran Reshef et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cell–Depleted Unrelated Donor Stem Cell Transplantation Provides Favorable Disease-Free Survival for Adults with Hematologic Malignancies

(2011) Ann A. Jakubowski et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell–Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous Leukemia in First Remission: Results of the Blood and Marrow Transplant Clinical Trials Network Protocol 0303

(2011) Steven M. Devine et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

(2011) A. M. Hanash et al.   BLOOD

Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease

(2011) J. L. M. Ferrara et al.   BLOOD

Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria

(2011) M. E. D. Flowers et al.   BLOOD

Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy

(2011) B. L. Laskin et al.   BLOOD

Risk factors for acute GVHD and survival after hematopoietic cell transplantation

(2011) M. Jagasia et al.   BLOOD

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

(2011) Marie Bleakley et al.   IMMUNOLOGY AND CELL BIOLOGY

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Danger signals activating innate immunity in graft-versus-host disease

(2011) Robert Zeiser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease—A Phase II Study

(2011) Larisa A. Kuzmina et al.   Stem Cells International

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Sirolimus immunosuppression for graft-versus-host disease prophylaxis and therapy: an update

(2010) Corey Cutler et al.   CURRENT OPINION IN HEMATOLOGY

Intervention with costimulatory pathways as a therapeutic approach for graft-versus-host disease

(2010) Byungsuk Kwon   EXPERIMENTAL AND MOLECULAR MEDICINE

High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation

(2010) Leo Luznik et al.   IMMUNOLOGIC RESEARCH

Reconstitution of self-tolerance after hematopoietic stem cell transplantation

(2010) Allan D. Hess   IMMUNOLOGIC RESEARCH

Elafin Is a Biomarker of Graft-Versus-Host Disease of the Skin

(2010) S. Paczesny et al.   Science Translational Medicine

Adult Human Mesenchymal Stem Cells Added to Corticosteroid Therapy for the Treatment of Acute Graft-versus-Host Disease

(2009) Partow Kebriaei et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Should Methotrexate plus Calcineurin Inhibitors Be Considered Standard of Care for Prophylaxis of acute Graft-versus-Host Disease?

(2009) Rainer Storb et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Chemokine Receptor CCR5 Mediates AlloImmune Responses in Graft-versus-Host Disease

(2009) Lisa A. Palmer et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

(2009) S. Sarantopoulos et al.   BLOOD

Extracorporeal photopheresis for the prevention of acute GVHD in patients undergoing standard myeloablative conditioning and allogeneic hematopoietic stem cell transplantation

(2009) P J Shaughnessy et al.   BONE MARROW TRANSPLANTATION

Allogeneic hematopoietic SCT in patients with non-malignant diseases and importance of chimerism

(2009) P Svenberg et al.   BONE MARROW TRANSPLANTATION

Using histone deacetylase inhibitors to enhance Foxp3+ regulatory T-cell function and induce allograft tolerance

(2009) Liqing Wang et al.   IMMUNOLOGY AND CELL BIOLOGY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Addition of Infliximab to Standard Acute Graft-versus-Host Disease Prophylaxis following Allogeneic Peripheral Blood Cell Transplantation

(2008) Mehdi Hamadani et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Long-Term follow-up of a Phase I/II Randomized, Placebo-Controlled Trial of Palifermin to Prevent Graft-versus-Host Disease (GVHD) after Related Donor Allogeneic Hematopoietic Cell Transplantation (HCT)

(2008) John E. Levine et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab

(2008) I. F. Khouri et al.   BLOOD

Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD

(2008) P Perfetti et al.   BONE MARROW TRANSPLANTATION

Risk Factors for Acute Graft-Versus-Host Disease After Human Leukocyte Antigen–Identical Sibling Transplants for Adults With Leukemia

(2008) Theresa Hahn et al.   JOURNAL OF CLINICAL ONCOLOGY

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET

Transfusion-associated graft-versus-host disease

(2008) D. M. Dwyre et al.   VOX SANGUINIS