Article
Biochemistry & Molecular Biology
Fuli Zhou, Fan Chen, Ziwei Ouyang, Rendi Zhu, Renpeng Zhou, Wei Hu, Chao Lu
Summary: Oxidative stress is common in autoimmune diseases, and PRDXs play a crucial role in reducing oxidative stress. Recent studies have found that almost all PRDX subtypes are involved in the development of autoimmune diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Cell Biology
Priyanka Pal, Samarjit Jana, Ipsita Biswas, Deba Prasad Mandal, Shamee Bhattacharjee
Summary: The use of cytotoxic chemotherapy dominates cancer treatment, but high doses of anticancer phytochemicals can lead to side effects. This study found that linalool, a phytochemical, has biphasic effects on cancer cells at different concentrations and may play a role in regulating angiogenesis and metastasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Se-Jin Jeong, Jong-Gil Park, Goo Taeg Oh
Summary: Increased oxidative stress is considered a common factor in the pathogenesis of cardiovascular disease, with precise regulation of ROS in cardiovascular cells essential for normal physiological functions. Antioxidant enzymes such as Prdxs play a crucial role in maintaining the balance of ROS levels and act as regulatory sensors of intracellular signals.
Review
Biotechnology & Applied Microbiology
Marcos Antonio de Oliveira, Carlos A. Tairum, Luis Eduardo Soares Netto, Ana Laura Pires de Oliveira, Rogerio Luis Aleixo-Silva, Vitoria Isabela Montanhero Cabrera, Carlos A. Breyer, Melina Cardoso dos Santos
Summary: The oxidative and nitrosative responses produced by animals and plants serve as crucial defenses against pathogenic microorganisms, including bacteria, fungi, and protozoa. Peroxiredoxins are enzymes that play a key role in decomposing hydroperoxides and can also function as molecular chaperones and phospholipases, contributing to microbial protection against host defenses. Some peroxiredoxins have been identified as virulence factors, indicating their significance in pathogenesis and potentially as targets for new antimicrobial drugs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Prince Saforo Amponsah, Galal Yahya, Jannik Zimmermann, Marie Mai, Sarah Mergel, Timo Muhlhaus, Zuzana Storchova, Bruce Morgan
Summary: Redox cycles play a crucial role in regulating metabolic and cell division cycles within cells, with oscillatory H2O2-dependent protein thiol oxidation serving as a key regulator. The cycling of H2O2 and peroxiredoxin oxidation during the YMC is essential for maintaining metabolic cycling and coupling it with cell division. Thiol-disulfide oxidants and reductants predictably modulate the switching between different metabolic states in the YMC, ultimately affecting cell cycle progression.
NATURE CHEMICAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yongquan Tang, Zhe Zhang, Yan Chen, Siyuan Qin, Li Zhou, Wei Gao, Zhisen Shen
Summary: ROS levels can be elevated in cancer cells due to antitumor therapeutics or immune response. High ROS levels can lead to cancer cell death by disrupting glycolysis and oxidative phosphorylation. However, cancer cells can adapt to these stresses by metabolic reprogramming, involving synthesis of NADPH and GSH for ROS scavenging, as well as upregulation of lipolysis and glutaminolysis for energy production. The underlying mechanism is not well understood, but manipulating metabolic adaptations could be a promising approach for cancer prevention and therapy.
Review
Biochemistry & Molecular Biology
Cinzia Forni, Massimiliano Rossi, Ilaria Borromeo, Giordana Feriotto, Giovambattista Platamone, Claudio Tabolacci, Carlo Mischiati, Simone Beninati
Summary: Plant metabolites like flavonoids have significant effects on human health, preventing diseases and exhibiting bioactivities such as anticancer and anti-inflammatory properties. Research shows that dietary intake of flavonoids can reduce the risk of cancer.
Article
Multidisciplinary Sciences
Ekta Agarwal, Aaron R. Goldman, Hsin-Yao Tang, Andrew V. Kossenkov, Jagadish C. Ghosh, Lucia R. Languino, Valentina Vaira, David W. Speicher, Dario C. Altieri
Summary: Parkin, an E3 ubiquitin ligase altered in Parkinson's disease, is shown to suppress tumor growth by shutting off mitochondrial dynamics and inhibiting the non-oxidative phase of the pentose phosphate pathway. This tumor suppression function of Parkin requires its E3 ligase activity and can be reversed by antioxidants, independently of mitophagy. Cancer metabolic networks are identified as potential oncogenes directly targeted by endogenous tumor suppression mechanisms.
Article
Biochemistry & Molecular Biology
Bess Yi Kun Yu, Maria-Armineh Tossounian, Stefan Denchev Hristov, Ryan Lawrence, Pallavi Arora, Yugo Tsuchiya, Sew Yeu Peak-Chew, Valeriy Filonenko, Sally Oxenford, Richard Angell, Jerome Gouge, Mark Skehel, Ivan Gout
Summary: NME1 is an evolutionarily conserved and multifunctional enzyme that plays a crucial role in suppressing tumor cell invasion and metastasis by regulating the balance of nucleotide diphosphates and triphosphates. Its NDPK activity can be inhibited by CoA through non-covalent and covalent interactions, providing a novel mechanism for the regulation of cell motility and metastasis.
Article
Oncology
Ke Wei, Zijian Ma, Fengming Yang, Xin Zhao, Wei Jiang, Chunfeng Pan, Zhihua Li, Xianglong Pan, Zhicheng He, Jing Xu, Weibing Wu, Yang Xia, Liang Chen
Summary: The study demonstrates that exosomes derived from M2 macrophages play a role in promoting invasion and migration of LUAD cells through miRNA regulation, providing a new therapeutic target for metastatic LUAD.
Article
Cell Biology
Shiyu Lin, Qi Zhang, Songhang Li, Xin Qin, Xiaoxiao Cai, Huiming Wang
Summary: In this study, a tetrahedral framework nucleic acids (tFNA)-based peptide delivery system was developed to address the stability and intracellular delivery issues of peptides in diabetic wound healing. The results showed that the delivery system improved angiogenesis and diabetic wound healing in vitro and in vivo, and exhibited antioxidative properties.
CELL PROLIFERATION
(2022)
Article
Microbiology
Maizbha U. Ahmed, Mohammad A. K. Azad, Mengyao Li, Darren J. Creek, Meiling Han, Fanfan Zhou, Kim Chan, Qi Tony Zhou, Tony Velkov, Jian Li
Summary: This study found that after 24 hours of treatment, polymyxin significantly reduced taurine and hypotaurine in lung epithelial cells, while significantly depleting reduced glutathione and increasing oxidized glutathione levels. In addition, polymyxins also affect key metabolic pathways such as cellular redox balance, mitochondrial beta-oxidation, and membrane lipid biogenesis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Oncology
Ossia M. Eichhoff, Corinne I. Stoffel, Jan Kasler, Luzia Briker, Patrick Turko, Gergely Karsai, Nina Zila, Verena Paulitschke, Phil F. Cheng, Alexander Leitner, Andrea Bileck, Nicola Zamboni, Anja Irmisch, Zsolt Balazs, Aizhan Tastanova, Susana Pascoal, Pal Johansen, Rebekka Wegmann, Julien Mena, Alaa Othman, Vasanthi S. Viswanathan, Judith Wenzina, Andrea Aloia, Annalisa Saltari, Andreas Dzung, Michael Krauthammer, Stuart L. Schreiber, Thorsten Hornemann, Martin Distel, Berend Snijder, Reinhard Dummer, Mitchell P. Levesque
Summary: The clinical management of NRAS-mutated melanomas is challenging due to resistance that arises through genetic, transcriptional, and metabolic adaptation. However, the adoption of a mesenchymal phenotype with a quiescent metabolic program in NRAS-mutated melanoma cells confers sensitivity to reactive oxygen species (ROS) induction, which can be inhibited by ROS inducers in combination with MAPK pathway inhibitors. The findings suggest that targeting both metabolic reprogramming and MAPK signaling could improve patient treatment in melanoma and other cancers.
Article
Biochemistry & Molecular Biology
Mojca Trstenjak Prebanda, Petra Matjan-Stefin, Boris Turk, Natasa Kopitar-Jerala
Summary: The study investigated the impact of lipopolysaccharide-triggered neuroinflammation on the protein levels of redox-sensitive proteins in the brain and cerebella of Stefin B-deficient mice. The results suggest a role of oxidative stress in the progression of the disease.
Article
Biochemistry & Molecular Biology
Kaveri R. Washimkar, Manendra Singh Tomar, Sharmeen Ishteyaque, Akhilesh Kumar, Ashutosh Shrivastava, Madhav Nilakanth Mugale
Summary: Benzo[a]pyrene (B[a]P) plays a pivotal role in lung carcinogenesis. This study investigates the effects of B[a]P on cell biology and the changes in a B[a]P-induced lung cancer model, which may be related to the development of lung cancer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Pilar Mur, Lorena Magraner-Pardo, Sandra Garcia-Mulero, Anna Diez-Villanueva, Jesus del Valle, Elsa Ezquerro, Conxi Lazaro, Gabriel Capella, Victor Moreno, Rebeca Sanz-Pamplona, Tirso Pons, Laura Valle
Summary: Germline variants affecting the proofreading activity of POLE and POLD1 can predispose to colorectal adenomas and carcinomas. Disruptive variants and missense variants outside the exonuclease domain (ED) of these polymerases generally do not predispose to cancer, but specific variants may indirectly affect proofreading activity. The variant POLD1 c.883G>A; p.(Val295Met) located upstream of the ED does not alter proofreading activity or associate with cancer.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Elisa Santovito, Sophia Elisseeva, Conor Smyth, Malco Cruz-Romero, Joseph P. Kerry, Geraldine Duffy, Dmitri B. Papkovsky
Summary: The study developed an oxygen sensor-based method for testing total aerobic viable counts (TVC) in raw meat samples and cattle carcass swabs, which is rapid, simple, affordable, and provides good sensitivity and analytical performance. The new method demonstrates good correlation with the ISO methods, allowing for improved microbial quality and safety of meat products and processes.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Dermatology
Maria del Carmen de Arriba, Geronimo Fernandez, Esteban Chacon-Solano, Manuel Mataix, Lucia Martinez-Santamaria, Nuria Illera, Rebeca Carrion-Marchante, Maria Elena Martin, Fernando Larcher, Victor M. Gonzalez, Marcela Del Rio, Marta Carretero
Summary: This study generated aptamers that specifically recognize and modulate the function of FPR2 involved in wound repair. These aptamers act as FPR2 agonists and have demonstrated potential therapeutic value in wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Iratxe Uranga-Murillo, Elena Morte, Sandra Hidalgo, Cecilia Pesini, Sandra Garcia-Mulero, Jose L. Sierra, Llipsy Santiago, Maykel Arias, Diego De Miguel, Maria Del Mar Encabo-Berzosa, Borja Gracia-Tello, Rebeca Sanz-Pamplona, Luis Martinez-Lostao, Eva M. Galvez, Jose R. Pano-Pardo, Ariel Ramirez-Labrada, Julian Pardo
Summary: This study examines the differences in immune response between COVID-19 patients, patients with non-COVID-19 respiratory tract infections, and healthy donors. The results show that COVID-19 patients exhibit a heterogeneous immune response, with the presence of activated and exhausted CD8+T and NK cells, as well as increased levels of various cytokines and chemokines.
Article
Oncology
Jose Javier Ruiz, Monica Marro, Ismael Galvan, Jose Bernabeu-Wittel, Julian Conejo-Mir, Teresa Zulueta-Dorado, Ana Belen Guisado-Gil, Pablo Loza-Alvarez
Summary: Raman spectroscopy combined with multivariate analysis has the potential to non-invasively diagnose skin tumors by characterizing their pigment composition. Differences in DHICA content allow for the accurate classification of dysplastic lesions in an objective, efficient, and cost-effective manner.
Article
Dermatology
Lucia Martinez-Santamaria, Rocio Maseda, Maria del Carmen de Arriba, Javier A. Membrilla, Alberto Iglesias Siguenza, Javier Mascias, Marta Garcia, Lucia Quintana, Isabel Esteban-Rodriguez, Carlos Pelayo Hernandez-Fernandez, Nuria Illera, Blanca Duarte, Sara Guerrero-Aspizua, David T. Woodley, Marcela del Rio, Raul de Lucas, Fernando Larcher, Maria Jose Escamez
Summary: This case report focused on a woman with EBS-MD who received gentamicin treatment for two courses, showing improvements in mucocutaneous involvement, muscle weakness, and quality of life. Laboratory tests and clinical scales showed positive outcomes, with gentamicin treatment leading to plectin expression in the skin for at least 5 months, and improvements in skeletal and respiratory muscle function.
Review
Biochemistry & Molecular Biology
Alejandra Mosteiro, Leire Pedrosa, Abel Ferres, Dioulde Diao, Angels Sierra, Jose Juan Gonzalez
Summary: This review focuses on the vascular microenvironment of glioblastoma, discussing the components of the perivascular niche, vascular generation patterns and signaling pathways, endothelial-tumor interrelation, and the connection between vessel aberrancies and immune disarrangement. The revised concepts provide novel insights into the failure of conventional anti-angiogenic therapies.
Article
Oncology
Hao Xu, Marie-Helene Lafage-Proust, Lamia Bouazza, Sandra Geraci, Philippe Clezardin, Bernard Roche, Francoise Peyrin, Max Langer
Summary: This study used synchrotron radiation microcomputed tomography (SR-mu CT) to investigate the effect of anti-angiogenic drugs on bone metastasis. The results suggest that combined anti-angiogenic drug treatment can reduce bone resorption at an early stage and affect bone microvascular structure at a later stage.
Article
Biochemical Research Methods
Chiara Zanetti, Rafael Di Lazaro Gaspar, Alexander V. Zhdanov, Nuala M. Maguire, Susan A. Joyce, Stuart G. Collins, Anita R. Maguire, Dmitri B. Papkovsky
Summary: This study describes a new family of heterosubstituted phosphorescent bioprobes based on the Pt(II)-tetrakis(pentafluorophenyl)porphyrin (PtPFPP) dye. The probes are produced by simple click modification and show good cell-penetrating ability and high reaction yields. Spectral characterization and cell-penetrating ability were evaluated using fluorescence reader and PLIM imaging detection. No significant cytotoxicity was observed for all of the probes under the experimental conditions used.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Anna Diez-Villanueva, Rebeca Sanz-Pamplona, Xavier Sole, David Cordero, Marta Crous-Bou, Elisabet Guino, Adriana Lopez-Doriga, Antoni Berenguer, Susanna Ausso, Laia Pare-Brunet, Mireia Obon-Santacana, Ferran Moratalla-Navarro, Ramon Salazar, Xavier Sanjuan, Cristina Santos, Sebastiano Biondo, Virginia Diez-Obrero, Ainhoa Garcia-Serrano, Maria Henar Alonso, Robert Carreras-Torres, Adria Closa, Victor Moreno
Summary: Colonomics is a multi-omics dataset that includes 250 samples from colon cancer patients and healthy colon mucosa donors. The project aims to explore and integrate these datasets to describe colon cancer at a molecular level and compare normal and tumoral tissues. Additionally, it aims to improve screening for colon cancer by finding biomarkers for diagnosis and prognosis.
Correction
Multidisciplinary Sciences
Anna Diez-Villanueva, Rebeca Sanz-Pamplona, Xavier Sole, David Cordero, Marta Crous-Bou, Elisabet Guino, Adriana Lopez-Doriga, Antoni Berenguer, Susanna Ausso, Laia Pare-Brunet, Mireia Obon-Santacana, Ferran Moratalla-Navarro, Ramon Salazar, Xavier Sanjuan, Cristina Santos, Sebastiano Biondo, Virginia Diez-Obrero, Ainhoa Garcia-Serrano, Maria Henar Alonso, Robert Carreras-Torres, Adria Closa, Victor Moreno
Review
Oncology
Margherita Puppo, Mariam Jaafar, Jean-Jacques Diaz, Virginie Marcel, Philippe Clezardin
Summary: This review discusses the roles of microRNAs and snoRNAs in the metastatic progression of cancer in bone. Dysregulation of microRNA and snoRNA expression in primary cancer cells leads to the acquisition of metastatic properties. Additionally, microRNAs and snoRNAs can act as intercellular mediators and remotely modulate the function of resident bone cells. Furthermore, the review explores the potential of microRNAs and snoRNAs as biomarkers and therapeutic targets in cancer treatments.
Letter
Dermatology
Rosa Sacedon, M. Carmen de Arriba, Lucia Martinez-Santamaria, Rocio Maseda, Sara Herraiz-Gil, Eva Jimenez, Isabel Rosales, Lucia Quintana, Nuria Illera, Marta Garcia, Nora Butta, Ihosvany Fernandez-Bello, Su M. Lwin, Miguel Fernandez-Arquero, Carlos Leon, John A. Mcgrath, M. Angeles Vicente, Marcela del Rio, Raul de Lucas, Silvia Sanchez-Ramon, Maria Jose Escamez
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Food Science & Technology
Sara Herraiz-Gil, Maria del Carmen de Arriba, Maria J. Escamez, Carlos Leon
Summary: The integration of multi-omics data enables comprehensive analysis of complex matrixes at the molecular level. Modern analytical techniques have been essential in advancing food science and understanding the relationships between food, health, and disease. However, there are still challenges in integrating all these data. This review provides an up-to-date critical overview of multi-omic approaches, their advantages, limitations, and recent research in the field of Foodomics.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ferran Moratalla-Navarro, Victor Moreno, Rebeca Sanz-Pamplona
Summary: Molecular crosstalk plays a significant role in cancer research, and TALKIEN is an online R/shiny application that visualizes molecular crosstalk information through protein-protein interaction network analysis. It helps users detect ligand-receptor interactions and generates in silico predictions for cell-cell communication, providing a translational rationale for future experiments.