Review
Polymer Science
Zheng Li, Muxin Yue, Yunsong Liu, Ping Zhang, Jia Qing, Hao Liu, Yongsheng Zhou
Summary: Organoids are novel in vitro cell culture models that recapitulate the characteristics of organs and have the ability for self-renewal and further differentiation. Hydrogel technology holds great potential for organoid culture.
Article
Engineering, Biomedical
Rui-Chian Tang, Lily Shang, Philip O. Scumpia, Dino Di Carlo
Summary: Researchers have developed a novel crescent-shaped hydrogel scaffold with a microporous structure that allows for improved cell infiltration and expansion. With the use of microfluidic fabrication, the size of the cavities in the scaffold can be adjusted, leading to enhanced cellular network formation in vitro and in vivo. The results suggest that this new scaffold has the potential for superior functionality in tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Article
Biophysics
Saeid Moghassemi, Arezoo Dadashzadeh, Hafez Jafari, Pejman Ghaffari-Bohlouli, Amin Shavandi, Christiani A. Amorim
Summary: This study developed a liposomal oxygen-releasing scaffold to address the inadequate oxygen supply in tissue engineering. The results showed that this method can improve cell viability under hypoxic conditions, providing a simple and effective solution for cellular oxygenation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Keisuke Fukada, Koji Tachibana, Yuta Kurashina, Yosuke Kaneko, Tatsuaki Matsumoto, Takeshi Miyamoto, Yasuo Niki, Masaya Nakamura, Hiroaki Onoe
Summary: This paper presents a scalable microfiber-shaped tissue for macroscale tendon tissue reconstruction in vitro. The microfiber-shaped tendon-like tissues maintained their morphology and showed proper expression of tenomodulin and actin filaments. A macro-scale tendon tissue assembly was successfully constructed by bundling the microfiber-shaped tendon-like tissues, allowing for uniform cell distribution.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Jiyun Cheng, Zheng Chen, Can Liu, Mei Zhong, Shihuan Wang, Yongjian Sun, Huiquan Wen, Tao Shu
Summary: This study successfully utilized 3D gelatin methacrylate hydrogel as a delivery system for transplanted exosomes, enhancing neuronal differentiation and extension of neural stem cells, while promoting neurogenesis and attenuating glial scars in damaged lesions.
Article
Chemistry, Multidisciplinary
Qingyi Hu, Kejun Dong, Jie Ming, Wen Yang, Hongbo Wang, Xianjin Xiao, Tao Huang
Summary: DNA hydrogels have unique properties that have led to increased research in nanomaterials and biomedical fields. However, the lack of effective methods to regulate microstructure limits their applications in tissue engineering. By introducing DNA scaffolds and implementing rapid self-assembly strategies, a regulable scaffold-net DNA hydrogel can be produced, offering a promising platform for cancer cell metastasis and microenvironment biophysics studies.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Annika C. Dell, Grayson Wagner, Jason Own, John P. Geibel
Summary: 3D bioprinting plays a crucial role in tissue engineering in medicine by providing precise and highly customizable methods for creating biological tissues. The selection of appropriate cell ink formulations is vital for process optimization and customization to suit target tissues. Hydrogel-based cell ink formulations show promise for future development in bioprinting technology.
Article
Materials Science, Biomaterials
Qingqing Liang, Cheng Liang, Xiaojing Liu, Xiaotao Xing, Shixing Ma, Haisen Huang, Chao Liang, Lei Liu, Li Liao, Weidong Tian
Summary: This study explores a novel strategy for dental pulp regeneration using cell-laden microfibers and validates the regeneration effect in vivo, which can generate more pulp tissue, blood vessels, and odontoblast-like cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Pengzhen Cheng, Tianqing Cao, Xueyi Zhao, Weiguang Lu, Sheng Miao, Fenru Ning, Dong Wang, Yi Gao, Long Wang, Guoxian Pei, Liu Yang
Summary: This study identifies the intracellular binding target of EV-NID1 and further elucidates a novel approach and mechanism, thereby providing a cell-free construction strategy with precise targets for the development of vascularized tissue engineering products.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Cristina Antich, Gema Jimenez, Juan de Vicente, Elena Lopez-Ruiz, Carlos Chocarro-Wrona, Carmen Grinan-Lison, Esmeralda Carrillo, Elvira Montanez, Juan A. Marchal
Summary: The development of a novel biomimetic hydrogel based on decellularized extracellular matrix derived from mesenchymal stem cells for cartilage tissue engineering has shown excellent biocompatibility and the ability to induce chondrogenesis without supplemental factors. This hydrogel also demonstrated the potential to form hyaline cartilage-like tissue after in vivo implantation, highlighting its promise for cartilage repair and regeneration applications.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Shuai Deng, Xiaoyu Zhao, Yanlun Zhu, Ning Tang, Rongliang Wang, Xuerao Zhang, Fuyang Qu, Yi-Ping Ho, Wayne Yuk-Wai Lee, Jiansu Chen, Mingqiang Li, Yu Tao, Hon Fai Chan
Summary: Liver tissue engineering is advanced through the fabrication of collagen type I microspheres, enabling efficient hepatic differentiation of stem cells and assembly of prevascularized liver tissue. The microspheres exhibit high uniformity and can self-assemble with endothelial cells to form high cell-packing density liver tissue. This technology has potential applications in regenerative medicine, drug screening, and in vitro liver modeling.
Review
Pharmacology & Pharmacy
Mohammad Samiei, Marziyeh Fathi, Jaleh Barar, Nazanin Fathi, Nazanin Amiryaghoubi, Yadollah Omidi
Summary: Regenerative medicine is a promising and rapidly growing field that aims to develop new functional tissues to treat defective cells/tissues and achieve precision medicine. To achieve optimal clinical outcomes, efficient and safe delivery of cell-based medicines to damaged areas is essential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Medicine, Research & Experimental
Mengyuan Wang, Ying Li, Hongqiao Wang, Meng Li, Xiaomin Wang, Rongzhen Liu, Daijun Zhang, Wenhua Xu
Summary: Corneal epithelial defects and excessive wound healing can cause severe complications. Stem cells offer a promising solution for regenerating the corneal epithelium and treating severe corneal epithelial injury. Biological scaffolds such as the amniotic membrane, fibrin, and hydrogels provide the necessary signals for stem cell proliferation and differentiation. Researchers have evaluated these scaffolds as potential therapeutic interventions for corneal disorders, identifying both benefits and drawbacks. This study provides a comprehensive overview of the history and use of stem cells in corneal repair, focusing on biological scaffolds used in stem cell transplantation and innovative materials under investigation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Junggeon Park, Nayeong Jeon, Sanghun Lee, Goeun Choe, Eunji Lee, Jae Young Lee
Summary: A conductive hydrogel with high electrical properties was developed using reduced graphene oxide (rGO) networks in graphene oxide (GO) coated agarose microbeads through thermal annealing. The conductive hydrogel showed excellent biocompatibility and potential applications in biomedicine.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yaser Hadadian, Hajar Masoomi, Ali Dinari, Chiseon Ryu, Seong Hwang, Seokjae Kim, Beong Ki Cho, Jae Young Lee, Jungwon Yoon
Summary: This study presents a comprehensive characterization of iron oxide nanoparticles synthesized using a thermal decomposition method. It found that varying the molar ratios of the starting materials can result in monodisperse nanoparticles with high saturation magnetization. The reduced magnetization in some samples was attributed to distortion and microstrain in the particles. Additionally, particles with lower surface coating and higher polydispersity exhibited lower saturation magnetization. The study concludes that the choice of molar ratios and heating profile is crucial for obtaining high-quality iron oxide nanoparticles.
Article
Polymer Science
Jin-Oh Jeong, Youn-Mook Lim, Jae Young Lee, Jong-Seok Park
Summary: A smart drug delivery system delivers drugs to specific sites and targets. Microneedle patches are effective in treating pain and preventing skin aging, but have mechanical weaknesses and low drug release efficiency. In this study, conductive stimuli microneedle patches were developed using the gamma-ray crosslinking technique for a smart drug delivery system.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Jun-Ho Jeong, Jae-Yeong Lee, Jae-Hyung Jang
Summary: An ultrathin linear-to-linear polarization converter with a high PCR in an ultrawide bandwidth was fabricated. It is based on a bilayer slot structure connected by via holes. The front- and back-sided slot structures, functioning as receivers and radiators respectively, are arranged orthogonally. The via holes transfer electromagnetic energy received by the front-sided slot structures to the back-sided slot structures, resulting in an electromagnetic wave with orthogonal polarization to that of the input wave.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Chemistry, Multidisciplinary
Byongyeon Kim, Junggeon Park, Jae Young Lee
Summary: In this study, double network (DN) hydrogels composed of sodium alginate (SA), polyacrylamide (PAAm), and graphene oxide (GO) were fabricated to improve elasticity, toughness, and mechanical strength. The composite hydrogels were reduced to improve electrical conductivity. The produced DN hydrogels exhibited excellent electrical conductivity, mechanical strength, and toughness, and can be used as strain sensors.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Mingyu Lee, Junggeon Park, Goeun Choe, Sanghun Lee, Bo Gyeong Kang, Ju Hee Jun, Yoonmin Shin, Min Chul Kim, Yong Sook Kim, Youngkeun Ahn, Jae Young Lee
Summary: Myocardial infarction (MI) is a major cause of death worldwide. We developed a hydrogel cardiac patch that provides mechanical support, electrical conduction, and tissue adhesiveness to aid in the recovery of an infarcted heart function. The MXene-based conductive and adhesive hydrogel (CAH) showed promising results in in vitro and in vivo studies, improving cardiac function and alleviating pathological remodeling of an infarcted heart.
Article
Chemistry, Multidisciplinary
Junggeon Park, Sanghun Lee, Mingyu Lee, Hyung-Seok Kim, Jae Young Lee
Summary: Injectable conductive hydrogels (ICHs) with tunable degradability have been developed as implantable bioelectrodes. ICHs exhibit good conductivity, tissue compatibility, and significantly improved sensitivity in electromyography signals compared to skin electrodes and nonconductive hydrogel electrodes. This study demonstrates the great potential of ICHs to develop various bioelectronic devices.
Article
Engineering, Biomedical
Sanghun Lee, Sehyeon Park, Junggeon Park, Jae Young Lee
Summary: We developed implantable bioelectrodes with high performance and high biocompatibility by actively modulating the inflammatory response of macrophages. The immobilization of anti-inflammatory cytokine IL-4 on the electrodes successfully induced anti-inflammatory polarization of macrophages, both in vitro and in vivo. These IL-4-immobilized bioelectrodes not only mitigated scarring around the implanted electrodes but also maintained high sensitivity electrocardiogram signals for up to 15 days post-implantation.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Yeonwoo Jang, April Kim, Hansoo Park, James J. Moon, Jae Young Lee
Summary: Cellular membrane-derived vesicles (CMVs) have unique advantages as a drug delivery system, but face challenges in yield, stability, and functionalization. This paper introduces three strategies to overcome these limitations: hybrid vesicles of CMVs and synthetic liposomes, core/shell nanostructures with synthetic nanoparticles and cell membrane structures, and CMV/scaffold complexes for sustained release. The authors propose that a combination of hybrid vesicle-coated nanoparticles or hybrid vesicle/scaffold complexes could be a promising drug delivery system.
APPLIED MATERIALS TODAY
(2023)
